National Cancer Institute, Maryland, USA invites multiple online application for Postdoctoral Fellowships in various research areas. Candidates interested in Postdoctoral Fellowships can check the details and may apply as soon as possible.
1. Postdoctoral Position
Summary of Postdoctoral Fellowship:
The Basic Science Program pursues independent, multidisciplinary research programs. Research efforts and support are an integral part of the Center for Cancer Research (CCR) at the Frederick National Laboratory for Cancer Research. This position is in the laboratory of Dr. Ruth Nussinov, a preeminent computational structural biologist. A postdoctoral fellowship in computational structural biology with Dr. Ruth Nussinov is available for a project at the Frederick National Laboratory for Cancer Research.
The project aims to decipher functional mechanisms of proteins to discover the structural basis of disease. It involves simulations of oncogenic proteins aiming to figure out their activation mechanisms, the actions of their driver mutations, signaling, allosteric drug discovery, and the emerging connection to neurodevelopmental disorders. These aims make it highly innovative. Experience and proficiency in high-performance molecular dynamics simulations, a good grasp of fundamental physical principles and their applications in biological systems to capture the behavior of proteins in full atomic detail and at very fine temporal resolution are required.
Application Deadline: Open Until Filled
2. Postdoctoral Position
Summary of Postdoctoral Fellowship:
A highly motivated candidate with a background in cancer genomics, computational biology, and/or bioinformatics or related field with an interest in data science. The candidate should have demonstrated experience in organizing, cleaning, and harmonizing large data sets, as well as in applying robust statistical methods, including multivariable analyses, machine learning. Knowledge of R and/or Python is required, and basic knowledge and understanding of clinical and biological interpretation of molecular data.
Application Deadline: Open Until Filled
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3. Postdoctoral Position
Summary of Postdoctoral Fellowship:
One postdoctoral position is immediately available with Dr. Kyung Lee in the Cancer Innovation Laboratory, CCR, NCI, to study Polo kinases and their associated scaffold proteins that orchestrate centrosomal organization, cell division, and tumorigenesis using cell biological, structural, and cryo-EM approaches.
Our research goal is to understand the function of mammalian polo-like kinase 4 and 1 (Plk4 and Plk1) that play central roles in regulating various biological events, including centriole duplication, bipolar spindle formation, chromosome segregation, cell division, and proliferation. During the past several years, we have been combining biochemical, cell biological, and structural approaches to delineate the molecular mechanisms governing Plk4/Plk1’s functionality on the centrosomal architecture, the deregulation of which can lead to the development of many human diseases, including cancer, microcephaly, and AIDS.
Application Deadline: Open Until Filled
4. Postdoctoral Position
Summary of Postdoctoral Fellowship:
The Fellowships in Surgical Oncology Research and Cancer Immunotherapy at the National Cancer Institute (NCI) encompass two time-honored programs combining bench-side research in surgical oncology with training in clinical research through direct patient care. The unique environment of the Clinical Center at the National Institutes of Health (NIH) allows for direct bedside-to-bench and bench-to-bedside translational research under the direction of world leaders in surgical oncology.
Application Deadline: Open Until Filled
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5. Postdoctoral Position
Summary of Postdoctoral Fellowship:
The Center for Immuno-Oncology (CIO) Translational Research area at the National Cancer Institute functions as a multidisciplinary and interdisciplinary translational research programmatic effort with the goal of developing novel immunotherapies and immunotherapeutic strategies for cancer. Focus is placed on the development of novel immunotherapeutics, not only as monotherapies, but more importantly, in combination with other immune-mediating modalities, and other conventional or experimental therapies, as part of an immuno-oncology programmatic effort. Within this effort are several research groups which interact closely with the clinical groups of the CIO, and with collaborators within the NCI intramural and extramural programs, and with investigators in the private sector. As Co-Director of the CIO, Dr. Jeffrey Schlom directs the Translational Research area of investigation.
Application Deadline: Open Until Filled
6. Postdoctoral Position
Summary of Postdoctoral Fellowship:
The NCI Urologic Oncology Fellowship offers a two- to three-year fellowship program in clinical service and laboratory training for urologic surgeons. Clinical training during the first year includes rotation to urological surgery service; providing consult service to patients, care for inpatients/outpatients on clinical protocols, and performing surgery. From 12-24 months, time is devoted to basic or clinical science research in laboratories/clinical programs, and one can choose to concentrate in either field. Fellows have their own patients which they follow to develop an understanding of care continuity and multidisciplinary management of patients with urologic cancers.
Application Deadline: Open Until Filled
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7. Postdoctoral Position
Summary of Postdoctoral Fellowship:
Fully funded postdoctoral and research fellow positions for experimental and computational biologists are available in Dr. Michael Aregger’s Functional Genomics Section within the Molecular Targets Program at the CCR, NCI, NIH. Our group’s research focuses on how cancer cells rewire gene expression and metabolism to adapt to changing environmental conditions.
We apply CRISPR-based genome engineering tools and functional genomics approaches to reveal genetic interactions and cancer dependencies, and to identify regulators of metabolic plasticity in cancer cells. Our lab focuses on developing innovative genetic screening approaches and we have access to state-of-the art facilities including next-generation sequencing, single-cell analysis platforms, mass spectrometry, flow cytometry, natural products and synthetic compound libraries, and animal facilities.
Application Deadline: Open Until Filled
8. Postdoctoral Position
Summary of Postdoctoral Fellowship:
Funded postdoctoral fellow positions are available in Dr. Colin Wu’s lab within the RNA Biology Laboratory at the National Cancer Institute (NCI) in Frederick, MD at the National Institute of Health (NIH). The major focus of the laboratory is to investigate the molecular mechanisms of translational regulation and non-canonical functions of the ribosome in mammalian systems.
Application Deadline: Open Until Filled
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9. Postdoctoral Position
Summary of Postdoctoral Fellowship:
Multiple post-doctoral positions are available with Dr. Lisa Boxer in the Laboratory of Genome Integrity to study chromatin regulation of neuronal development. The Boxer lab uses molecular and genomic approaches to study how mutations in chromatin regulators disrupt neuronal gene expression and lead to neurodevelopmental disorders and cancer.
Dr. Boxer is part of a highly integrated, interactive and collaborative research environment that provides an ideal training and mentoring setting for young scientists. Her research group will be adjacent to the laboratories of Branch Chief Andre Nussenzweig, Senior Investigators Eros Lazzerini Denchi and Avinash Bhandoola, and Stadtman Investigator Sergio Ruiz Macias.
Application Deadline: Open Until Filled
10. Postdoctoral Position
Summary of Postdoctoral Fellowship:
A postdoctoral position is available in the Women’s Malignancies Branch in the laboratory of Patricia S. Steeg, Ph.D. The laboratory focuses on molecular and cellular aspects of breast cancer metastasis to the brain, and the translation of experimental data to the clinic.
Application Deadline: Open Until Filled
11. Postdoctoral Position
Summary of Postdoctoral Fellowship:
We offer one fully funded postdoctoral position up to five years in the Laboratory of Genome Integrity located at the Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH). NIH is the largest biomedical research agency in the world, fosters world-renowned researchers and provides access to state-of-the art innovative technologies and scientific resources.
Our laboratory uses human and mouse embryonic stem cells, as well as mouse embryos to understand the molecular mechanisms underlying cell fate decisions. The applicant will be involved in a very exciting project investigating the relation between cell plasticity/totipotency and chromatin architecture (see our last publication about this topic,.
Application Deadline: Open Until Filled
12. Postdoctoral Position
Summary of Postdoctoral Fellowship:
A computational biology postdoctoral position is available in Dr. Ruppin’s lab within the Cancer Data Science Laboratory (CDSL), CCR, NCI, to participate in a variety of projects. Postdocs are expected and encouraged to develop their own project of interest as well. The CDSL is a large, active and highly supportive niche for training in cancer data science, with numerous opportunities to collaborate with cancer biologists.
Application Deadline: Open Until Filled
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13. Postdoctoral Position
Summary of Postdoctoral Fellowship:
Two postbaccalaureate positions are available (2023-2025) to study the role of Wnt signaling pathways in stem cell self-renewal and differentiation. We are studying a population of multipotent axial progenitors, called neuromesodermal progenitors (NMPs), which arise during gastrulation and generate the spinal cord and somites of the trunk and tail. The Wnt/beta-catenin signaling pathway activates gene regulatory networks (GRNs) to regulate NMP development.
The candidate will study how transcription factors function in these GRNs to regulate NMP self-renewal and differentiation. Our studies are largely focused on the mouse embryo but Xenopus (Frog) and embryonic stem cell-based in vitro differentiation models, including gastruloid/organoid 3D cultures, are also employed. Candidates will gain experience with a variety of genomic, cellular, molecular and developmental biology techniques.
Application Deadline: Open Until Filled
14. Postdoctoral Position
Summary of Postdoctoral Fellowship:
A post-baccalaureate fellow position is available in the Loncarek Lab, Centrosome Biology Section, within the Cancer Innovation Laboratory, CCR, NCI in Frederick, Maryland. The focus of the laboratory is to investigate cellular mechanisms that regulate the number and architecture of centrosomes in normal and transformed human cells.
The successful applicant will investigate how cell cycle regulators control centriole biogenesis, and will join our effort to dissect centrosome architecture in nanoscale resolution, using various super resolution microscopy approaches. The fellow will benefit highly from rigorous training in molecular biology, biochemistry, advanced microscopy, mammalian cell culture, scientific writing, and from working in a collaborative group with an extensive network of domestic and international collaborators.
Application Deadline: Open Until Filled
15. Postdoctoral Position
Summary of Postdoctoral Fellowship:
Funded postdoctoral fellow positions are available in Dr. Colin Wu’s lab within the RNA Biology Laboratory, CCR, NCI, NIH in Frederick, MD. The major focus of the laboratory is to investigate the molecular mechanisms of translational regulation and non-canonical functions of the ribosome in mammalian systems.
Multiple projects are available: (1) developing and applying high-throughput sequencing approaches to characterize in vivo dynamics of the ribosome and RNA-binding proteins; (2) exploring non-canonical functions of the ribosome in signal transduction; (3) characterizing local translation-coupled RNA decay and protein quality control. The positions offer rigorous training opportunities in multiple disciplines to build a new high-impact research program.
Application Deadline: Open Until Filled
16. Postdoctoral Position
Summary of Postdoctoral Fellowship:
We are recruiting talented, skilled, mature and dedicated postdoctoral, graduate student and postbaccalaureate fellows to undertake ambitious and challenging projects in the area of chromosome/chromatin biology with a focus on epigenetic pathways in normal and cancer cells. The Dalal lab is within the exceptionally rated, integrative, and interactive Laboratory of Receptor Biology and Gene Expression, CCR, NCI, in the intramural research program of NIH in Bethesda, MD.
Our lab focuses on the relationship between histone variants, lncRNAs, and establishment of aberrant epigenetic signatures in human cancer progression. We are especially proud of our diverse group of successful fellows who use cutting-edge single molecule technologies (high speed AFM, nano-indentation), IF/FISH, genomics, biochemistry, computational modeling and genetics to discover new epigenetic pathways in mitosis and cancer progression using human cells and 3D-printed tumor models. New projects are focused on using these tools to study chromosomes and chromatin in micronuclei, in 3D-printed tumor models, and in aging cells.
Application Deadline: Open Until Filled
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17. Postdoctoral Position
Summary of Postdoctoral Fellowship:
Postdoctoral training positions are currently available in the Vaccine Branch, CCR, National Cancer Institute, in Frederick, MD. The positions are in the group headed by Barbara K. Felber, Ph.D., whose lab focuses on nucleic acid vaccines against AIDS and COVID-19 and on cytokines for vaccine and cancer.
Application Deadline: Open Until Filled
18. Postdoctoral Position
Summary of Postdoctoral Fellowship:
Two postdoctoral positions are available at the Genomic Stability and Metabolism Group (PI: Urbain Weyemi, Ph.D.) within the Developmental Therapeutics Branch, CCR, NCI in Bethesda, Maryland. Our group aims to understand the dialogue between genomic instability and metabolism in human diseases, particularly in cancer and neurodegeneration. We apply multiple genomics and metabolomics tools to assess how changes in genome repair pathways affect metabolic abilities of cancer cells. Our goal is to understand how cancer cells undergo metabolic reprogramming to escape therapeutic agents targeting DNA repair.
Application Deadline: Open Until Filled
19. Postdoctoral Position
Summary of Postdoctoral Fellowship:
We are seeking a postdoctoral researcher to join the Biological Computing Section (BCS), Center for Structural Biology (CSB), Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Frederick, MD. The BCS group develops algorithmic solutions to address the increasing demands for quantitative and computational approaches in electron microscopy, integrative structural biology, and materials science. You will be working in a creative collaborative team developing and applying novel computational solutions for analyzing high-dimensional noisy image data.
Application Deadline: Open Until Filled
20. Postdoctoral Position
Summary of Postdoctoral Fellowship:
Postdoctoral fellow positions in both computational biology and cancer biology are available in Dr. Ma’s lab within the Cancer Data Science Laboratory (CDSL), CCR, NCI. Programming and analytical skillsets are required for positions in computational biology. A strong wet-lab background is required for tumor biology. A background in molecular biology, genetics, immunology, computational biology, bioinformatics, or a similar field is preferred but not required.
Application Deadline: Open Until Filled
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21. Postdoctoral Position
Summary of Postdoctoral Fellowship:
A postdoctoral fellowship is available to study the role of pericytes to promote pre-metastatic niche formation and metastatic progression in the laboratory of Meera Murgai, Laboratory of Cancer Biology and Genetics, CCR, NCI, NIH, Bethesda, Maryland. The postdoctoral fellow will focus on interrogating pericyte heterogeneity and plasticity in the metastatic microenvironment, following up on work published in our Nature Medicine 2017 article.
The post-doctoral fellow will be trained in techniques related to cancer biology, vascular biology and computational analysis of gene expression, epigenetic, and microscopy datasets to further our understanding of the metastatic microenvironment in experimental models and patient data. Extra consideration will be given to candidates with an interest in the relationship between epigenetic states and cell fate decisions.
Application Deadline: Open Until Filled
22. Postdoctoral Position
Summary of Postdoctoral Fellowship:
The O’Reilly lab is seeking a postdoctoral fellow who wants to join our interdisciplinary team to integrate whole-cell crosslinking mass spectrometry and cryo-electron microscopy with protein complex modeling and structure prediction. We have projects that include large-scale protein interactome mapping and more focused structural biology applications. There are two major study areas: Discovering and characterizing novel protein complexes across the human microbiome. Understanding structural changes in human protein complexes on the path to cancer.
Application Deadline: Open Until Filled
23. Postdoctoral Position
Summary of Postdoctoral Fellowship:
The O’Reilly lab is seeking a postdoctoral fellow who wants to join our interdisciplinary team to develop crosslinking mass spectrometry and other structural proteomics techniques to map the protein-interactomes of whole cells. We have two major avenues of study: Discovering and characterizing novel protein complexes across the human microbiome Understanding structural changes in human protein complexes on the path to cancer
Application Deadline: Open Until Filled
24. Postdoctoral Position
Summary of Postdoctoral Fellowship:
A postdoctoral position is available in the Inflammation and Tumorigenesis Section headed by Yinling Hu, Ph.D., in the Cancer Innovation Laboratory, CCR, NCI, Frederick, MD. This research laboratory is studying inflammation- and infection-associated skin, lung, and esophageal cancer by using multidisciplinary approaches including single-cell RNA sequencing, RNA-seq, gene expression regulation, lipidomics, glucose metabolism, tumor-associated microbiota, analysis of human cancer genomic alterations, genetically engineered mouse models, and cellular and biochemical methods (PMID 35121655 PNAS; PMID 28407484 Cell Host Microbe; PMID 23597566 Cancer Cell). This is a great opportunity to join an exciting basic and translational cancer research program.
Application Deadline: Open Until Filled
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25. Postdoctoral Position
Summary of Postdoctoral Fellowship:
A postdoctoral position is immediately available in the laboratory of Dr. Joana Vidigal, LBMB, CCR, NCI, NIH. The Vidigal lab aims to understand how small RNA pathways centered on Argonaute (AGO) proteins regulate mammalian physiology with a strong focus on mouse genetics. Current projects seek to define the regulation of AGO proteins in vivo and the mechanistic details through which they impact mouse development, homeostasis, and disease. In an exciting new area of research, the Vidigal lab is exploring how the functions of AGO2 are regulated between proliferating and quiescent cells as well as the requirement for direct RNA cleavage by AGO2 in quiescence through its conserved but poorly understood catalytic domain.
Application Deadline: Open Until Filled
26. Postdoctoral Position
Summary of Postdoctoral Fellowship:
A postdoctoral fellow position is available in the laboratory of Dr. Yuichi Machida in the Developmental Therapeutics Branch (DTB), CCR, NCI, NIH to study DNA repair mechanisms and their effect on anti-cancer drugs. Dr. Machida’s research focuses on proteases involved in the repair of DNA-Protein Crosslink (DPC) damage. The successful candidate will study proteolytic DPC repair mechanisms using molecular and cellular biology techniques as well as mouse genetics.
Application Deadline: Open Until Filled
27. Postdoctoral Position
Summary of Postdoctoral Fellowship:
The Eukaryotic Transcriptional Regulation Section in the Mouse Cancer Genetics Program at CCR, NCI, seeks a highly motivated postdoctoral researcher to participate in a project exploring mechanisms that control cellular responses to oncogenic RAS signaling.
The project focuses on the novel role of 3’UTRs in regulating phosphorylation/activation of the encoded proteins by oncogenic kinases such as ERK1/2 and CK2. The mechanism involves mRNA partitioning, in part through localized, 3’UTR-mediated mRNA decay adjacent to perinuclear kinases in tumor cells. Our research is highly interdisciplinary and intersects the fields of RNA biology, signaling and cancer biology. Talented individuals who wish to pursue an independent research track will have the opportunity to develop their own projects toward the end of their training period.
Application Deadline: Open Until Filled
28. Postdoctoral Position
Summary of Postdoctoral Fellowship:
The Mouse Cancer Genetics Program, CCR, NCI (Frederick, MD) is now recruiting a postdoctoral fellow. The successful candidate should have a background in neurobiology and/or physiology and basic expertise in molecular biology, cell biology, immunohistochemistry, biochemistry and imaging. Candidates with expertise in electrophysiology are also encouraged to apply. Our group studies the biology of neurotrophin and Trk receptor’s function by using both in vitro and in vivo approaches. The current research emphasis is on understanding the molecular mechanisms underlying Trk receptor’s physiological functions. In addition, we are attempting to identify new signaling pathways activated by truncated Trk receptors.
Application Deadline: Open Until Filled
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29. Postdoctoral Position
Summary of Postdoctoral Fellowship:
A postdoctoral fellow position is available in the laboratory of Dr. Chongyi Chen in the Laboratory of Biochemistry and Molecular Biology at the CCR, NCI, NIH in Bethesda, MD. The potential projects are to investigate the dynamics and regulation of DNA topology upon mitotic chromosome condensation, and to investigate the role of DNA topology in gene expression regulation in human cells. The Chen lab studies chromatin structure, DNA topology, and gene expression regulation in human cells, using various genomic technologies and single-cell sequencing assays newly invented in the lab.
Application Deadline: Open Until Filled
30. Postdoctoral Position
Summary of Postdoctoral Fellowship:
A post-doctoral fellow position is available in the Thoracic Surgery Branch, CCR, NCI, NIH. Our broad goal is to explore the molecular and cellular biology of thoracic cancers, namely mesothelioma and/or, thymoma, non-small cell lung carcinoma, etc. Currently, we have projects that involve (1) investigating microRNA-mRNA interactions in malignant mesothelioma, (2) novel local therapeutic delivery system(s) able to carry diverse types of payloads including nucleic acid, immunotherapeutics, targeted small molecule agents, or antibodies,
(3) on the pathogenic signaling pathways relevant to tumor initiation, invasion, metastasis, and resistance, (4) constructing next-generation models of normal cells/tissues that can be used to model tumor development and processes as well as several other translational-based endeavors (e.g., developing novel tumor diagnostics and prognostics, etc.).
With these projects, we have aims of developing novel molecular biomarkers and therapeutic targets based on an understanding of the pathogenetic mechanisms active in these cancers. The culmination of these projects will be linked to clinical human protocols in these thoracic cancers of interest.
Application Deadline: Open Until Filled
31. Postdoctoral Position
Summary of Postdoctoral Fellowship:
A postdoctoral position is available in the laboratory of Dr. Laurie Krug, HIV and AIDS Malignancy Branch (HAMB), Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH). The successful applicant will be part of a team focused on the mechanisms by which gammaherpesviruses establish life-long infection and cause cancer. Our lab is dedicated to applying animal models of disease to understand viral and host determinants of chronic infection by the gammaherpesviruses. The mission is to identify novel targets for intervention and prevention of human gammaherpesvirus-driven cancers.
Application Deadline: Open Until Filled
32. Postdoctoral Position
Summary of Postdoctoral Fellowship:
A Postdoctoral research position is available at the National Cancer Institute (NCI), National Institutes of Health, Bethesda, MD, USA, in the group of Dr. Ramiro Iglesias-Bartolome at the Laboratory of Cellular and Molecular Biology starting March 2023. Our laboratory research focuses on elucidating the signaling mechanisms that control and drive tissue-specific stem cell self-renewal and differentiation and their connections to tumor initiation and growth using the skin as a model system. The project focuses on elucidating the role of G-protein-coupled receptors in epithelial stem cell fate decisions and cancer by using mouse and cell line models. The candidate will have access to state-of-the-art genomic, proteomic and imaging technologies.
Application Deadline: Open Until Filled
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33. Postdoctoral Position
Summary of Postdoctoral Fellowship:
One post-doctoral position is immediately available with Dr. Andre Nussenzweig in the Laboratory of Genome Integrity, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH) to study the mechanisms involved in DNA double-strand break repair, with a focus on understanding the influence of chromatin structure on the maintenance of genome integrity and their roles in a variety of cancers using cutting-edge cellular, molecular, and genomic tools.
Application Deadline: Open Until Filled
34. Postdoctoral Position
Summary of Postdoctoral Fellowship:
One post-doctoral position is immediately available with Dr. Andre Nussenzweig in the Laboratory of Genome Integrity, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), to use computational methods in the study of mechanisms involved in DNA double-strand break repair and the roles of repair proteins in a variety of cancers that include leukemias and breast cancers, using mouse models.
The position will emphasize efforts to understand gene regulation, chromatin, regulatory and structural variation and its relation to cancer. The position will involve analysis of applications involving high-throughput DNA sequencing methods for a variety of assays, including RNA-seq, exon sequencing, ATAC-seq, DNase-seq, ChIP-seq, END-seq and newer, cutting-edge methodologies that are in development.
Application Deadline: Open Until Filled
35. Postdoctoral Position
Summary of Postdoctoral Fellowship:
Seeking a Post-Doctoral Fellow for the Surgery Branch under the supervision of the Branch Chief, Steven A. Rosenberg, M.D., Ph.D.. The Surgery Branch is a combined laboratory and clinical research unit devoted to the development of innovative cancer immunotherapies and their subsequent translation to the treatment of patients with cancer. Candidates should be completing or have completed a doctoral degree in a scientific field related to immunology.
Application Deadline: Open Until Filled
36. Postdoctoral Position
Summary of Postdoctoral Fellowship:
A postdoctoral fellowship position is available in the laboratory of Natalie Porat-Shliom. Ph.D., within the Center for Cancer Research (CCR), NCI, NIH, in Bethesda, Maryland. Candidates are sought to join a basic and translational research program focused on hepatocytes cell biology and non-alcoholic fatty liver disease. Our lab is interested in fundamental questions related to mitochondrial biology in the liver.
How are mitochondrial structure and function regulated? What are the environmental cues/stressors that induce these mitochondrial alterations? And, in turn, how are those disrupted in human disease? For this, we use intravital microscopy, the study of cellular processes in live, anesthetized rodents (Cunningham and Porat-Shliom 2021, Stefkovich et al 2021, Porat-Shliom et al. 2019). A benefit of this position is the opportunity to learn state-of-the-art light microscopy imaging techniques.
Application Deadline: Open Until Filled
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37. Postdoctoral Position
Summary of Postdoctoral Fellowship:
A post-doctoral position is available in the laboratory of Avinash Bhandoola at the National Cancer Institute. The laboratory studies the development of T cells, innate lymphocytes, and thymic epithelial cells. New cellular intermediates in the development of innate lymphocytes were recently described by Dr. Bhandoola’s lab, and we wish to evaluate the role of specific transcription factors in this process. Other work in the laboratory studies regulation of thymus growth, and is focused on identifying new types of thymic epithelial cells and transcription factors important for their function.
Application Deadline: Open Until Filled
38. Postdoctoral Position
Summary of Postdoctoral Fellowship:
A postdoctoral position is available in the RNA Biology Laboratory, Center for Cancer Research, NCI, NIH. The candidate will perform basic research on small RNA functions. MicroRNAs (miRNAs) play critical roles in both mammalian development and human diseases such as cancer. The goal of our program is to study how miRNAs themselves are regulated, and to apply gained insights into developing effective treatments for cancer. Using genetic studies in living cells and animals, together with biochemical and next-generation sequencing (NGS) approaches, our laboratory focuses on elucidating mechanisms of miRNA biogenesis and the roles that miRNAs play in tumorigenesis.
Application Deadline: Open Until Filled
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39. Postdoctoral Position
Summary of Postdoctoral Fellowship:
A postdoctoral position to discover mechanisms of drug resistance regulated by cell polarity proteins (PMID: 30996345), cellular plasticity, and clonal evolution in the breast or pancreatic cancer (PMID: 32990680) is available in the lab of Dr. Senthil Muthuswamy at the Laboratory of Cancer Biology and Genetics (LCBG), National Cancer Institute, NIH, Bethesda, MD. The Muthuswamy laboratory was among the first to employ three-dimensional cell culture (now referred to as organoid culture) to bridge the gap between growing cells as a flat monolayer and tumors growing in vivo.
They apply a microscope-to-stethoscope approach that combines basic cell biology investigations with clinical translation, as evidenced by the successful completion of a clinical trial: Harnessing Organoids for PErsonalized therapy (HOPE) in pancreatic cancer. Studies in his lab use the organoid platform to understand how cell polarity proteins regulate drug resistance and cell metabolism, T-cell-tumor cell interactions, metastatic progression, and develop personalized cancer treatments.
Application Deadline: Open Until Filled
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40. Postdoctoral Position
Summary of Postdoctoral Fellowship:
A postdoctoral fellowship is available for individuals interested in discovering and characterizing tumor-targeting T-cell receptors and immune evasion mechanisms in the breast or pancreatic cancer using an organoid-T-cell coculture platform (PMID:34789550; 35446942) in the lab of Dr. Senthil Muthuswamy at the Laboratory of Cancer Biology and Genetics (LCBG), National Cancer Institute, NIH, Bethesda, MD.
The Muthuswamy laboratory was among the first to employ three-dimensional cell culture (now referred to as organoid culture) to bridge the gap between growing cells as a flat monolayer and tumors growing in vivo. They apply a microscope-to-stethoscope approach that combines basic cell biology investigations with clinical translation, as evidenced by the successful completion of a clinical trial:
Harnessing Organoids for PErsonalized therapy (HOPE) in pancreatic cancer. Studies in his lab use the organoid platform to understand how cell polarity proteins regulate drug resistance and cell metabolism, T-cell-tumor cell interactions, metastatic progression, and develop personalized cancer treatments.
Application Deadline: Open Until Filled
41. Postdoctoral Position
Summary of Postdoctoral Fellowship:
Postdoctoral positions are immediately available in the laboratory of Dr. Shiv Grewal, Laboratory of Biochemistry and Molecular Biology, CCR, NCI, NIH. The Grewal lab aims to uncover fundamental principles governing the assembly and epigenetic inheritance of heterochromatin, a repressive form of chromatin that controls gene expression and protects genome stability.
The major focus of the lab is on understanding how highly conserved RNA-based mechanisms and chromatin modifying activities assemble heterochromatin at specific sites across the genome, and how repressive chromatin structures are epigenetically inherited. Current projects seek to define the roles of novel RNA processing factors in the formation of large heterochromatin domains and uncover the mechanisms by which modified histones provide an epigenetic template to propagate repressive chromatin, which is critical for stable maintenance of gene expression patterns during development.
In other exciting areas of interest, the lab is exploring how heterochromatin assembly impacts 3D genome organization and investigating adaptive genome control, in which heterochromatic structures are dynamically modulated in response to environmental or developmental cues to allow appropriate gene expression profiles.
Application Deadline: Open Until Filled
42. Postdoctoral Position
Summary of Postdoctoral Fellowship:
The Protein and Chromatin Folding Section, Laboratory of Biochemistry and Molecular Biology, CCR, NCI, NIH is recruiting a postdoctoral fellow. Candidates with an interest in chromatin structure and its relationship to cancer are encouraged to apply. The DNA molecules in eukaryotic cells are associated with histone proteins to form chromatin that can fold to various structures for the purpose of biological functions.
The folding of chromatin is regulated by many other non-histone protein factors. We study chromatin folding through determination of the structures and dynamics of chromatin units and their complexes with regulatory proteins using single particle cryo-EM, X-ray crystallography, solution NMR, and other biophysical/biochemical methods.
Our most recent studies include the high-resolution structural determination of chromatosomes with different linker histone isoforms, centromeric nucleosomes bound to kinetochore proteins, and nucleosomes with native DNA sequences and how they are recognized by pioneer transcription factors.
Application Deadline: Open Until Filled
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43. Postdoctoral Position
Summary of Postdoctoral Fellowship:
A post-doctoral position in neuroscience is available in the lab of Dr. Chuan Wu, Experimental Immunology Branch, CCR, NCI in Bethesda, MD. The laboratory’s research interest focuses on how neuron-immune interactions regulate mucosal sensation for barrier integrity in health and disease. We seek to study how immune signaling participates in gut sensation and regulates gut-brain axis. We are also exploring new therapeutic approaches for patients with intestinal inflammation and related extraintestinal manifestations. We are utilizing interdisciplinary approaches to elucidate the crosstalk between the nervous system, microbial pathogens, and the immune system.
Application Deadline: Open Until Filled
