National Cancer Institute (NCI), Maryland invites multiple online application for Postdoctoral Positions in various research areas. Candidates interested in Postdoctoral Fellowships can check the details and may apply as soon as possible.
1. Post-doctoral Fellow – Prostate cancer, translational research
Summary of Postdoctoral Fellowships:
A postdoctoral researcher position in the fields of cell biology, translational cancer research, and/or molecular pathology is available in the laboratory of Adam Sowalsky (Prostate Cancer Genetics Section) at the CCR, NCI, NIH. The Sowalsky Lab is a part of the Laboratory of Genitourinary Cancer Pathogenesis, an interdisciplinary group entirely focused on prostate cancer. The major goals of the Sowalsky Lab are to identify molecular characteristics of patients with prostate cancer based on their responses to therapy, validate those features as biomarkers, and test them in clinical trials at the NIH Clinical Center. Together with our collaborators in the urology and oncology branches, we are generating unique and very large, high-volume datasets with extensive clinical annotation, with the goal of identifying opportunities for integrating precision medicine into clinical practice.
Application Deadline: Open Until Filled
2. Post-doctoral Fellow – Liver cancer, computational biology, genomics
Summary of Postdoctoral Fellowships:
The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies.
Application Deadline: Open Until Filled
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3. Post-doctoral Fellow – Immunology, immunotherapy, glioma
Summary of Postdoctoral Fellowships:
The NOB, CCR, NCI, NIH in Bethesda, Maryland is seeking outstanding and highly motivated postdoctoral fellow candidates for a fellowship position in laboratory research on immunology of primary brain cancer. The position is in the NOB’s basic immunology program led by Masaki Terabe, Ph.D., whose goal is to develop novel immunotherapies for primary brain cancer patients. The basic immunology program primarily focuses on the roles of T cells, especially unconventional T cells such as NKT cells and MAIT cells, in the regulation of tumor immunity against primary brain cancer. Candidates are expected to join a basic, translational, and collaborative research program.
Application Deadline: Open Until Filled
4. Post-doctoral Fellow – DNA damage, DNA repair, computational biology, genomics
Summary of Postdoctoral Fellowships:
One post-doctoral position is immediately available with Dr. Andre Nussenzweig in the Laboratory of Genome Integrity, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), to use computational methods in the study of mechanisms involved in DNA double-strand break repair and the roles of repair proteins in a variety of cancers that include leukemias and breast cancers, using mouse models. The position will emphasize efforts to understand gene regulation, chromatin, regulatory and structural variation and its relation to cancer. The position will involve analysis of applications involving high-throughput DNA sequencing methods for a variety of assays, including RNA-seq, exon sequencing, ATAC-seq, DNase-seq, ChIP-seq, END-seq and newer, cutting-edge methodologies that are in development.
Application Deadline: Open Until Filled
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5. Post-doctoral Fellow – DNA damage, DNA repair, genomics
Summary of Postdoctoral Fellowships:
One post-doctoral position is immediately available with Dr. Andre Nussenzweig in the Laboratory of Genome Integrity, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH) to study the mechanisms involved in DNA double-strand break repair, with a focus on understanding the influence of chromatin structure on the maintenance of genome integrity and their roles in a variety of cancers using cutting-edge cellular, molecular, and genomic tools.
Application Deadline: Open Until Filled
6. Post-doctoral Fellow – Neuro-endocrine cancer, molecular biology, epigenetics
Summary of Postdoctoral Fellowships:
The Sadowski Lab is seeking a motivated postdoctoral fellow interested in working at the interface of molecular pathophysiology of cancer progression and therapy of human cancers using targeted radiopharmaceuticals. Our laboratory program is dedicated to studying the epigenetic regulation of aggressive endocrine cancer and identifying novel and effective targeted therapies for personalized treatment of metastatic endocrine cancers. Applicants will gain experience in patient-derived organoid culture techniques, animal models, cancer genomics and preclinical drug development. Endocrine oncology at NIH encompasses unique patient cohorts of rare endocrine cancers, and our multi-disciplinary program has the capacity to translate preclinical findings into clinical trials, with the purpose of improving patient outcomes.
Application Deadline: Open Until Filled
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7. Post-doctoral Fellow – Tumor cellular immunology, cancer vaccines
Summary of Postdoctoral Fellowships:
A highly motivated postdoctoral fellow is sought to work on tumor immunology with a strong background in biology preferentially molecular and cellular immunology. The tumor immunology team in the laboratory is exploring mechanisms of improving vaccines and immunotherapy for cancer, especially by discovering new principles to enhance and steer T cell immune responses. The group is focusing on negative immunoregulatory mechanisms used for immune evasion by cancer cells. The postdoctoral fellow will work on a project to study novel immunomodulatory agents and their ability to promote the efficacy of cancer vaccines and immunotherapy in mouse tumor models, both through blockade of negative regulation and stimulation of effector mechanisms. Group members also have an opportunity to gain knowledge of HIV/mucosal immunology by interacting with the HIV research group in the lab.
Application Deadline: Open Until Filled
8. Post-doctoral Fellow – X-ray crystallography, HIV
Summary of Postdoctoral Fellowships:
A postdoctoral fellowship is available to study the molecular basis of how HIV and other virus-encoded proteins hijack the centrosome duplication machinery and induce aneuploidy that can lead to carcinogenesis. The primary focus will be on determining the X-ray crystal structures for the complexes that we have isolated from our recent studies. The ultimate goal of this research is to determine the etiology of centrosome abnormality–associated cancers or other human disorders and to devise novel strategies to tackle them. Related to this project, we are also taking biochemical and cell biological approaches, including super-resolution imaging, single molecule tracking, and in vitro reconstitution to delineate the mechanism of governing Polo-like kinase 4 and 1 (Plk4/Plk1)’s functionality on the centrosomal architecture, the deregulation of which can lead to the development of many human diseases, including cancers.
Application Deadline: Open Until Filled
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9. Biologist – Neurodevelopmental disorders, cancer
Summary of Postdoctoral Fellowships:
A biologist position is available with Dr. Lisa Boxer in the Laboratory of Genome Integrity at the CCR, NCI. The Boxer lab uses molecular and genomic approaches to study how mutations in chromatin regulators disrupt neuronal gene expression and lead to neurodevelopmental disorders and cancer. The applicant will oversee the lab’s mouse colony and set up breedings and genotype mice as needed. The applicant should also have significant hands-on experience with molecular and cellular biology techniques such as primary cell culture, nucleic acid manipulations, and protein analysis. S/he will be responsible for creating an efficient and productive scientific environment in support of the laboratory’s research studies. In addition, s/he will have overall day-to-day responsibilities for the efficient management and use of laboratory resources, as well as other scientific and administrative duties including lab organization, distribution of lab tasks, and ordering.
Application Deadline: Open Until Filled
10. Post-doctoral Fellow – CRISPR screening, next generation sequencing
Summary of Postdoctoral Fellowships:
A postdoctoral position is available in the Molecular and Cell Biology Section in the Neuro-Oncology Branch, CCR, NCI, NIH. The position is offered to apply a whole genome approach in the study of mechanisms involved in cancer therapy resistance, such as DNA repair and metabolic reprogramming. The ideal candidate will play a leading role in providing computational and biological insights by analyzing large data sets derived from genomics, epigenetics, and proteomics experiments. The position will involve the design, preparation, and analysis of applications involving high-throughput DNA sequencing methods for a variety of assays, including RNA-seq, exon sequencing, ATAC-seq, DNase-seq, ChIP-Seq, and genetic screening.
Application Deadline: Open Until Filled
11. Post-doctoral Fellow – Bioinformatics, data science
Summary of Postdoctoral Fellowships:
Postdoctoral researcher positions in Bioinformatics and Cancer Data Sciences are available in the laboratory of Peng Jiang at the CCR, NCI, NIH. The overarching goal of the Jiang Lab is to understand the process of cancer immune evasion and therapy resistance through large-scale data integration and artificial intelligence approaches. The candidate will develop statistical and machine learning frameworks to advance our ability to treat cancer patients. Meanwhile, as the Jiang Lab has experts from both computational and wet-lab aspects, this bioinformatics postdoc position will benefit substantially from the experimental validation support in the same team to make novel scientific discoveries. Dr. Jiang will spend significant efforts on the candidates to ensure training success.
Application Deadline: Open Until Filled
12. Post-doctoral Fellow – Immunology, developmental biology, molecular biology
Summary of Postdoctoral Fellowships:
Fully funded postdoctoral fellow positions are available in Dr. Yousuke Takahama’s Thymus Biology Section in the Experimental Immunology Branch (EIB), Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH) in Bethesda, MD. The laboratory focuses on the biology of the thymic microenvironments that contribute to the generation of functionally potent and self-tolerant T cells. The candidate will perform basic research on the development and function of diverse thymic epithelial cell subpopulations. Please visit our website for more information.
Application Deadline: Open Until Filled
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13. Senior Investigator – RNA biology
Summary of Postdoctoral Fellowships:
The National Cancer Institute (NCI), Center for Cancer Research (CCR), RNA Biology Laboratory (RBL) is seeking an outstanding, internationally known scientist to lead an independent research group focused on any area of RNA biology. The successful candidate will be part of the newly established RBL on the Frederick, Maryland campus. The RBL, which is the equivalent of a small department at an academic institution, was formed in 2017 to enhance RNA research at the NCI. The successful candidate will be eligible to be appointed as an NIH tenured Senior Investigator, a position equivalent to a tenured Associate Professor or Professor at a university. The investigator will be able to take advantage of the stable resources provided by the Intramural Research Program to lead a world-class research program.
Application Deadline: Open Until Filled
14. Post-doctoral Fellow – T cell development, regeneration
Summary of Postdoctoral Fellowships:
A post-doctoral position is available in the laboratory of Avinash Bhandoola at the National Cancer Institute. The laboratory studies the development of T cells, innate lymphocytes, and thymic epithelial cells. New cellular intermediates in the development of innate lymphocytes were recently described by Dr. Bhandoola’s lab, and we wish to evaluate the role of specific transcription factors in this process. Other work in the laboratory studies regulation of thymus growth, and is focused on identifying new types of thymic epithelial cells and transcription factors important for their function. The laboratory is adjacent to the laboratories of Andre Nussenzweig, Eros Lazzerini Denchi, and Sergio Ruiz, and the four laboratories together are an outstanding training and research environment.
Application Deadline: Open Until Filled
15. Post-doctoral Fellow – Brain tumors, lipid metabolism, cancer biology
Summary of Postdoctoral Fellowships:
One postdoctoral position is available in the Larion laboratory at the Neuro-Oncology Branch, CCR, NCI. My laboratory is focused on understanding the metabolic changes in brain tumors. In particular, we are interested in revealing the lipid alterations of isocitrate dehydrogenase (IDH1)-mutated gliomas and in exploiting these deregulations for therapeutic applications. We employ a combination of methods such as molecular biology, animal models, as well as in vitro and in vivo metabolomics using Raman Imaging Microscopy, and Mass Spectrometry (MS). The postdoctoral fellow will explore the link between lipid gene alterations in brain tumors and their biology. This position requires expertise in Western Blotting, mammalian cell culture and other common biomedical techniques used in cancer biology labs such as handling tissue samples, preparing tissue slides, staining, and extraction of proteins from brain tissue.
Application Deadline: Open Until Filled
16. Post-doctoral Fellow – Cancer chromatin, lncRNAs, micronuclei
Summary of Postdoctoral Fellowships:
We are recruiting talented, skilled, mature and dedicated postdoctoral, graduate student and postbaccalaureate fellows to undertake ambitious and challenging projects in the area of chromosome/chromatin biology with a focus on epigenetic pathways in normal and cancer cells. The Dalal lab is at the National Cancer Institute within the exceptionally rated, integrative, and interactive Laboratory of Receptor Biology and Gene Expression in the intramural research program of NIH in Bethesda, MD. Our lab focuses on the relationship between histone variants, lncRNAs, and establishment of aberrant epigenetic signatures in human cancer progression. We are especially proud of our diverse group of successful fellows who use cutting-edge single molecule technologies (high speed AFM, nano-indentation), IF/FISH, genomics, biochemistry, computational modeling and genetics to discover new epigenetic pathways in mitosis and cancer progression using human cells and 3D-printed tumor models. New projects are focused on using these tools to study chromatin in micronuclei, in 3D-printed tumor models, and in aging cells.
Application Deadline: Open Until Filled
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17. Clinical Fellow – urology, oncology, fellowship, training
Summary of Postdoctoral Fellowships:
The NCI Urologic Oncology Fellowship offers a two- to three-year fellowship program in clinical service and laboratory training for urologic surgeons. Clinical training during the first year includes rotation to urological surgery service; providing consult service to patients, care for inpatients/outpatients on clinical protocols, and performing surgery. From 12-24 months, time is devoted to basic or clinical science research in laboratories/clinical programs, and one can choose to concentrate in either field. Fellows have their own patients which they follow to develop an understanding of care continuity and multidisciplinary management of patients with urologic cancers. Core curriculum covers prostate, bladder, kidney, testis and penile cancer, in addition to experience with advanced minimally invasive surgical techniques and management of patients with locally advanced and advanced genitourinary malignancies and systemic therapy.
Application Deadline: Open Until Filled
18. Post-doctoral Fellow – Immunology, immunotherapy
Summary of Postdoctoral Fellowships:
The Center for Immuno-Oncology (CIO) functions as a multidisciplinary and interdisciplinary translational and clinical research programmatic effort with the goal of developing novel immunotherapies for cancer. The CIO focuses on the development of novel immunotherapeutics for human cancer, not only as monotherapies, but more importantly, in combination with other immune-mediating modalities, and other conventional or experimental therapies, as part of an immuno-oncology programmatic effort. Within this effort are several research groups, a clinical trials group, and multiple collaborations with intramural and extramural scientific and clinical investigators and with investigators in the private sector.
Application Deadline: Open Until Filled
19. Post-doctoral Fellow – Structural biology, chromatin structure
Summary of Postdoctoral Fellowships:
The Protein and Chromatin Folding Section, Laboratory of Biochemistry and Molecular Biology, CCR, NCI, NIH is recruiting a postdoctoral fellow for applicants with an interest in chromatin structure and its relationship to cancer. The DNA molecules in eukaryotic cells are associated with histone proteins to form chromatin that can fold to various structures for the purpose of biological functions. The folding of chromatin is regulated by many other non-histone protein factors. We study chromatin folding through determination of the structures and dynamics of chromatin units and their complexes with regulatory proteins using single particle cryo-EM, X-ray crystallography, solution NMR, and other biophysical/biochemical methods. Our most recent studies include the high-resolution structural determination of chromatosomes with different linker histone isoforms, centromeric nucleosomes bound to kinetochore proteins, and nucleosomes with native DNA sequences and how they are recognized by pioneer transcription factors.
Application Deadline: Open Until Filled
20. Post-doctoral Fellow – Heterochromatin assembly, epigenetic inheritance
Summary of Postdoctoral Fellowships:
Postdoctoral positions are immediately available in the laboratory of Dr. Shiv Grewal, Center for Cancer Research, NCI, NIH. The Grewal lab aims to uncover fundamental principles governing the assembly and epigenetic inheritance of heterochromatin, a repressive form of chromatin that controls gene expression and protects genome stability. The major focus of the lab is on understanding how highly conserved RNA-based mechanisms and chromatin modifying activities assemble heterochromatin at specific sites across the genome, and how repressive chromatin structures are epigenetically inherited. Current projects seek to define the roles of novel RNA processing factors in the formation of large heterochromatin domains and uncover the mechanisms by which modified histones provide an epigenetic template to propagate repressive chromatin, which is critical for stable maintenance of gene expression patterns during development.
Application Deadline: Open Until Filled
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21. Post-doctoral Fellow – Computational biology
Summary of Postdoctoral Fellowships:
A computational biology postdoctoral position is available in Dr. Ruppin’s lab within the Cancer Data Science Laboratory (CDSL), CCR, NCI, to participate in a variety of projects. Postdocs are expected and encouraged to develop their own project of interest as well. The CDSL is a large, active and highly supportive niche for training in cancer data science, with numerous opportunities to collaborate with cancer biologists.
Application Deadline: Open Until Filled
22. Post-doctoral Fellow – Computational biology
Summary of Postdoctoral Fellowships:
A computational biology postdoctoral position is available in the Hannenhalli lab within the Cancer Data Science Laboratory (CDSL), CCR, NCI, to participate in a variety of projects investigating cellular heterogeneity and function in the tumor microenvironment, utilizing a variety of single cell and bulk multi-omics data. Postdocs are expected and encouraged to develop their own project of interest as well. The CDSL is a large, active and highly supportive niche for training in cancer data science, with numerous opportunities to collaborate with cancer biologists.
Application Deadline: Open Until Filled
23. Post-doctoral Fellow – RNA biology
Summary of Postdoctoral Fellowships:
We are recruiting a highly motivated postdoctoral researcher to study the impact of RNA post-transcriptional modifications on gene expression and cell identity. Our laboratory aims to understand, at the molecular level, how interactions between cellular environment and the RNA epigenome impact the RNA-centric regulatory networks that control cell identity, and how disruption of such pathways contribute to: 1) the establishment and proliferation of tumors; and 2) the development of resistance against therapeutic intervention. We employ a very broad range of state-of-the-art techniques including RNA-seq, proteomics and CRISPR genome editing.
Application Deadline: Open Until Filled
24. Post-doctoral Fellow – Molecular modeling, computational biology
Summary of Postdoctoral Fellowships:
A post-doctoral position is available in the Cancer Data Science Lab in computational structural biology to study the structure and function of cell surface proteins and engineer optimized chimeric antigen receptor constructs, integrating structural, biophysical and biological constraints. It is a key position in an interdisciplinary project bridging structural biology (cryoEM, NMR, Xray), computational biology, cell biology and clinical trials. Chimeric Antigen Receptors (CAR) are the backbone of CAR-T cell therapies (https://www.cancer.gov/about-cancer/treatment/research/car-t-cells). They are the focus of over 700 clinical studies being conducted worldwide. Many teams throughout the world are focusing on the optimization of CAR-Ts for the treatment of patients with relapsed/refractory cancers but the vast majority of studies are performed by an empirical trial and error approach. This project brings together expertise in CAR-T cell biology, structural biology, computational structural modeling and machine learning to develop a rational design approach.
Application Deadline: Open Until Filled
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25. Staff Scientist – Immunometabolism, analytical chemistry
Summary of Postdoctoral Fellowships:
The Cancer Innovation Laboratory (CIL) located in Frederick, MD is a component of the Center for Cancer Research (CCR), at the NCI, NIH, and is supervised by Dr Daniel W. McVicar. The CIL hosts a metabolic facility that supports investigators of the CIL, CCR and NIH community, with expertise across metabolism, immunology, and analytical chemistry to support investigator-driven research in cancer immunometabolism. The facility supports experimental design, sample preparation, mass spectrometry analysis, data analysis and interpretation in metabolomics. In addition, the facility supports analysis of stable isotope tracing in immune cells and at the immune-cancer interface.
Application Deadline: Open Until Filled
26. Post-doctoral Fellow – Molecular analysis of thoracic malignancy
Summary of Postdoctoral Fellowships:
A post-doctoral fellow position is available in the Thoracic Surgery Branch, CCR, NCI, NIH. Our broad goal is to explore the molecular and cellular biology of thoracic cancers, namely mesothelioma and/or, thymoma, non-small cell lung carcinoma, etc. Currently, we have projects that involve (1) investigating microRNA-mRNA interactions in malignant mesothelioma, (2) novel local therapeutic delivery system(s) able to carry diverse types of payloads including nucleic acid, immunotherapeutics, targeted small molecule agents, or antibodies, (3) on the pathogenic signaling pathways relevant to tumor initiation, invasion, metastasis, and resistance, (4) constructing next-generation models of normal cells/tissues that can be used to model tumor development and processes as well as several other translational-based endeavors (e.g., developing novel tumor diagnostics and prognostics, etc.). With these projects, we have aims of developing novel molecular biomarkers and therapeutic targets based on an understanding of the pathogenetic mechanisms active in these cancers. The culmination of these projects will be linked to clinical human protocols in these thoracic cancers of interest.
Application Deadline: Open Until Filled
27. Post-doctoral Fellow – Liver cancer research, liver biology, genetics
Summary of Postdoctoral Fellowships:
Postdoctoral positions are available in the laboratory of Dr. Xin Wei Wang, Laboratory of Human Carcinogenesis, CCR, NCI, to study functional genomics of liver cancer.
Application Deadline: Open Until Filled
28. Post-doctoral Fellow – Embryonic stem cells, Chromatin architecture
Summary of Postdoctoral Fellowships:
We offer one fully funded postdoctoral position up to five years in the Laboratory of Genome Integrity located at the Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH). NIH is the largest biomedical research agency in the world, fosters world-renowned researchers and provides access to state-of-the art innovative technologies and scientific resources. Our laboratory uses human and mouse embryonic stem cells, as well as mouse embryos to understand the molecular mechanisms underlying cell fate decisions. The applicant will be involved in a very exciting project investigating the relation between cell plasticity/totipotency and chromatin architecture (see our last publication about this topic, https://www.nature.com/articles/s41467-021-25072-x). We seek a highly motivated, creative individual, eager to learn and develop new technologies and complex cell systems based on live cell/embryo imaging, single-cell technologies and CRISPR-based editing who is interested in understanding how a single cell can develop into a complex multicellular organism in vitro and in vivo.
Application Deadline: Open Until Filled
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29. Post-doctoral Fellow – Neuronal development and disorders, Chromatin regulation
Summary of Postdoctoral Fellowships:
Multiple post-doctoral positions are available with Dr. Lisa Boxer in the Laboratory of Genome Integrity to study chromatin regulation of neuronal development. The Boxer lab uses molecular and genomic approaches to study how mutations in chromatin regulators disrupt neuronal gene expression and lead to neurodevelopmental disorders and cancer. Dr. Boxer is part of a highly integrated, interactive and collaborative research environment that provides an ideal training and mentoring setting for young scientists. Her research group will be adjacent to the laboratories of Branch Chief Andre Nussenzweig, Senior Investigators Eros Lazzerini Denchi and Avinash Bhandoola, and Stadtman Investigator Sergio Ruiz Macias.
Application Deadline: Open Until Filled
30. Post-doctoral Fellow – Immunology, cell death
Summary of Postdoctoral Fellowships:
A fully funded postdoctoral fellow position in immunology is available in the laboratory of Dr. Christian T. Mayer at the Experimental Immunology Branch, CCR, NCI, starting October 1, 2022. The laboratory is investigating how different types of programmed cell death regulate the development, differentiation and/or function of various immune cells. Moreover, the group explores how such pathways contribute to self-tolerance, autoimmunity, inflammatory diseases, protective immunity and/or malignancies. Additional information can be found at: https://ccr.cancer.gov/staff-directory/christian-t-mayer
Application Deadline: Open Until Filled
31. Post-doctoral Fellow – Cell signaling, stem cells, cancer
Summary of Postdoctoral Fellowships:
We seek highly motivated postdoctoral fellows interested in developing independent research projects in the area of cell signaling at the interface of development, stem cells and cancer. We combine functional genomics, genome editing, cell biology and biochemistry to study how signaling pathways are used, reused and repurposed to drive the myriad different cellular processes that give rise to tissues and organs during embryonic development and maintain them in adult life. A major focus of the lab is on WNT signaling, a fundamental pathway that orchestrates embryonic patterning and morphogenesis, promotes stem cell self-renewal and tissue regeneration, and can be a potent cancer driver when it becomes dysregulated. We use powerful genetic screens in human cells to discover new regulatory mechanisms and probe their molecular underpinning through biochemistry and cell biology.
Application Deadline: Open Until Filled
32. Post-doctoral Fellow – Developmental signal transduction
Summary of Postdoctoral Fellowships:
Signaling from Eph receptor tyrosine kinases and the ephrin transmembrane ligands affect morphogenesis during development and have been shown to play an instructive role in angiogenesis, as well as tumor cell invasion. Since we found a connection between the key Wnt signaling scaffold, Dishevelled, and ephrinB proteins, we have extended our analysis to examine how the intersection of Wnt/Planar Cell Polarity (PCP) and ephrinB signaling alters the mechanisms of signal transduction of these pathways. Moreover, we investigate how the output of these pathways lead to the creation of highly ordered intricate structures during development. Both Xenopus (Frog) and mammalian tissue culture systems are employed in projects that involve the functional and molecular characterization of the cellular and developmental effects mediated by the ephrinB and Wnt pathway proteins.
Application Deadline: Open Until Filled
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33. Post-doctoral Fellow – Development, genetics
Summary of Postdoctoral Fellowships:
A postdoctoral position is available immediately in the lab of Dr. Mark Lewandoski to study the genetics of development in the mammalian embryo. The focus of the lab is the role of cell-to-cell signaling during axis determination, segmentation, and limb development with an emphasis on FGF signaling. Outstanding opportunities exist to collaborate, obtain further training and present research at intramural, society, and international meetings.
Application Deadline: Open Until Filled
34. Post-doctoral Fellow – Engineering CAR-T/NK for cancer immunotherapies
Summary of Postdoctoral Fellowships:
CAR-T cell-based immunotherapy has shown promising efficacy in some hematologic tumors. However, this approach has shown limitations in major solid tumors, including liver cancer and pancreatic cancer. Dr. Mitchell Ho’s lab at the National Cancer Institute (NCI) Center for Cancer Research (CCR) has characterized cell surface proteins such as glypicans (GPC3 and GPC2), mesothelin and B7-H3 as tumor-associated targets. To develop next-generation cell-based therapies, we are engineering potent CAR constructs for T or natural killer (NK) cell-based therapies via antibody protein engineering and computational design. Some of our research has led to clinical trials for treating cancer patients.
Application Deadline: Open Until Filled
35. Post-doctoral Fellow – Transplantation, cellular therapy, immunotherapy
Summary of Postdoctoral Fellowships:
We are recruiting a highly motivated postdoctoral research fellow to develop new engineered T-cell therapies that can be integrated directly with allogeneic hematopoietic cell transplantation (HCT) to reduce post-transplant malignancy relapse. Projects also will include mechanistic studies of graft-versus-host disease (GVHD) prevention in murine HCT models. Allogeneic HCT is the only curative therapy for many hematologic malignancies and life-threatening but non-malignant hematologic diseases. The use of post-transplantation cyclophosphamide (PTCy) as GVHD prophylaxis recently has revolutionized the HCT field by making HCT available to nearly all patients and effectively preventing both severe acute and chronic GVHD. However, the mechanisms underlying PTCy’s clinical efficacy had been poorly understood until recent paradigm-shifting work performed in the laboratory of Dr. Christopher Kanakry (e.g., https://www.jci.org/articles/view/124218).
Application Deadline: Open Until Filled
36. Post-doctoral Fellow – Computational genomics, algorithms
Summary of Postdoctoral Fellowships:
Multiple postdoctoral and Ph.D. student positions are available under the supervision of Dr. Mikhail Kolmogorov at the CCR, NCI, NIH. The Kolmogorov Lab is part of the Cancer Data Science Laboratory, a new initiative dedicated to translational omics research and tightly integrated with basic and translational projects at the NCI. The general focus of Dr. Kolmogorov’s group is computational genomics – algorithms, mathematical models and tools aimed to answer fundamental questions about living systems through the analysis of large-scale genomic data. The group is currently seeking applicants with an interest in developing and/or applying computational methods for cancer genomics and metagenomics. Possible projects include but are not limited to: analysis of complex chromosomal rearrangements in cancer, haplotype-resolved assembly of complex polyploid genomes, deconvolution of complex metagenomic communities, genome graph representations, genomic analysis of large patient cohort data. We are also open to other computational projects candidates would like to propose, as long as they fit our general direction.
Application Deadline: Open Until Filled
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37. Post-doctoral Fellow – Functional genomics, cancer metabolism
Summary of Postdoctoral Fellowships:
Fully funded postdoctoral and research fellow positions for experimental and computational biologists are available in Dr. Michael Aregger’s Functional Genomics Section within the Molecular Targets Program at the CCR, NCI, NIH. Our group’s research focuses on how cancer cells rewire gene expression and metabolism to adapt to changing environmental conditions. We apply CRISPR-based genome engineering tools and functional genomics approaches to reveal genetic interactions and cancer dependencies, and to identify regulators of metabolic plasticity in cancer cells. Our lab focuses on developing innovative genetic screening approaches and we have access to state-of-the art facilities including next-generation sequencing, single-cell analysis platforms, mass spectrometry, flow cytometry, natural products and synthetic compound libraries, and animal facilities.
Application Deadline: Open Until Filled
38. Post-doctoral Fellow – Molecular biology, biochemistry
Summary of Postdoctoral Fellowships:
A postdoctoral position is available in the Molecular and Cell Biology Section, Laboratory of Cellular Oncology, CCR, NCI, NIH to investigate vascular and immune targeting approaches for solid cancers. The project will focus on exploiting immune and vascular therapies to induce cancer cell death or senescence, thereby restricting tumor growth. The project will involve in vitro and in vivo mouse models as well as in silico experiments.
Application Deadline: Open Until Filled
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39. Senior Biomedical Research Scientist 1 – Bioinformatics
Summary of Postdoctoral Fellowships:
CCR faces the need to sunset an existing data system which is being retired by its vendor, and this affords us the opportunity to architect our replacement around the 21st-century needs and goals of collaborative early-phase research. As part of this transition, the CCR Office of Information Technology seeks to hire a bioinformatics expert with specific expertise in development, implementation, and maintenance of clinical trials data management systems to become the owner for CCR’s replacement early-phase clinical trials research data system. This system will directly support the research mission of the NCI’s intramural clinical research program. CCR physicians develop and conduct a wide range of clinical trials in a quest to develop the medicines of tomorrow for patients with cancer, HIV or immunodeficiency disorders.
Application Deadline: Open Until Filled
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40. Post-doctoral Fellow – Bioinformatics, cancer therapy, chromatin
Summary of Postdoctoral Fellowships:
A postdoctoral position is available at the DNA Replication Group (PI: Mirit I. Aladjem, Ph.D.), in collaboration with the Molecular Pharmacology Group (PI: Dr. Yves Pommier, M.D., Ph.D.) of the Developmental Therapeutics Branch, CCR, NCI in Bethesda, Maryland. Our groups aim to understand mechanistic insights into cellular networks that modulate cancer cell proliferation and identify targets for intervention in cancer. Since many regulatory feedback pathways are deregulated in cancer cells, the results of our studies will help our understanding of cancer biology and the mechanisms underlying therapeutic strategies.
Application Deadline: Open Until Filled
41. Post-baccalaureate Fellow – Tumor metastasis, therapeutic resistance
Summary of Postdoctoral Fellowships:
Post-baccalaureate fellow positions are available in Dr. Li Yang’s Tumor Microenvironment and Metastasis Section within the Laboratory of Cancer Biology and Genetics, Center for Cancer Research, NCI, NIH in Bethesda, Maryland. Our group’s research focuses on how cancer cells interact with and adapt to the changing immune microenvironment in metastatic process and therapeutic resistance. We utilize proteomics, single cell sequencing, and functional genomics approaches to identify key regulators. Several projects are currently available including: 1) dying tumor cells and the extracellular matrix in breast cancer metastasis and therapeutic resistance; 2) immune microenvironment and tumor dormancy; and 3) epigenetic regulation of tumor suppressor genes and host immune response.
Application Deadline: Open Until Filled
42. Post-doctoral Fellow – Tumor metastasis, therapeutic resistance
Summary of Postdoctoral Fellowships:
Postdoc positions are available in Dr. Li Yang’s Tumor Microenvironment and Metastasis Section within the Laboratory of Cancer Biology and Genetics, Center for Cancer Research, NCI, NIH in Bethesda, Maryland. Our group’s research focuses on how cancer cells interact with and adapt to the changing immune microenvironment in metastatic process and therapeutic resistance. We utilize proteomics, single cell sequencing, and functional genomics approaches to identify key regulators. Several projects are currently available including: 1) dying tumor cells and the extracellular matrix in breast cancer metastasis and therapeutic resistance; 2) immune microenvironment and tumor dormancy; and 3) epigenetic regulation of tumor suppressor genes and host immune response.
Application Deadline: Open Until Filled
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43. Post-doctoral Fellow – Cancer immunology, immunotherapy
Summary of Postdoctoral Fellowships:
Seeking a Post-Doctoral Fellow for the Surgery Branch under the supervision of the Branch Chief, Steven A. Rosenberg, M.D., Ph.D.. The Surgery Branch is a combined laboratory and clinical research unit devoted to the development of innovative cancer immunotherapies and their subsequent translation to the treatment of patients with cancer. Candidates should be completing or have completed a doctoral degree in a scientific field related to immunology.
Application Deadline: Open Until Filled
44. Staff Scientist – Cancer biology, genetics
Summary of Postdoctoral Fellowships:
The Laboratory of Pathology, CCR, NCI, NIH, Bethesda, MD, is actively recruiting a staff scientist to work in the Cancer Molecular Pathology section headed by Frederic G. Barr, M.D., Ph.D. This research section uses a multidisciplinary approach involving genomics and bioinformatics along with cell culture and animal models to study genetic and epigenetic alterations in cancer. By initially focusing on specific cancer types, such as the rhabdomyosarcoma family of myogenic soft tissue cancers, this research laboratory is investigating the molecular basis, biological consequences and clinical significance of chromosomal translocations, amplification events, point mutations and methylation changes in these cancers. The methodologies, reagents and concepts from these studies are then being applied to address these issues in other relevant cancer categories.
Application Deadline: Open Until Filled
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45. Post-doctoral Fellow – Sphingolipid & phospholipid signaling in mammals
Summary of Postdoctoral Fellowships:
The Sphingolipid and Phospholipid Signaling Section, Jairaj K. Acharya, MBBS, Ph.D, Head, and the Cancer and Developmental Biology Laboratory, CCR, NCI, has an immediate opening for a postdoctoral position to study in vivo impact of sphingolipid metabolic enzymes in hematologic malignancies and organ function using a combination of genetic, molecular, biochemical and cell biological methodologies in mouse model systems. With nation-wide responsibility for improving the health and well-being of all American citizens, the U.S. Department of Health and Human Services oversees the biomedical research programs of the National Institutes of Health (NIH) and those of its 27 Institutes and Centers.
Application Deadline: Open Until Filled
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46. Post-doctoral Fellow – Radiation, normal tissue, senescence
Summary of Postdoctoral Fellowships:
A fully funded postdoctoral position is available in Dr. Deborah Citrin’s laboratory within the Radiation Oncology Branch at the CCR, NCI, Bethesda, Maryland. Major projects in the laboratory focus on the identification of molecules involved in determining cell/tissue radioresponse, evaluating methods to impact senescence/aging, and the development of target-based therapies. Opportunities are available for using a variety of genetic and molecular biology approaches to delineate the molecules/processes that regulate cellular radiosensitivity. Studies will also involve translating fundamental information relating to molecular radioresponse to strategies aimed at increasing the sensitivity of tumor cells or protecting normal tissues.
Application Deadline: Open Until Filled
47. Post-doctoral Fellow – Alternative splicing regulation, functional genomics
Summary of Postdoctoral Fellowships:
A fully funded postdoctoral fellow position is open in the Gonatopoulos-Pournatzis lab within the RNA Biology Laboratory at the CCR, NCI, NIH in Frederick, MD. Our research focuses on characterizing regulatory networks that control alternative splicing and on the systematic interrogation of transcript isoforms with critical roles in normal physiology and disease states. We address these questions by applying functional genomics combined with molecular biology and biochemical approaches as well as the generation of animal models. We have pioneered the development and application of genome-scale CRISPR methodologies for elucidating the functional and regulatory landscapes of transcript isoform diversity. Our lab possesses state-of-the-art equipment including next-generation sequencers for short and long reads, single-cell analysis platforms and we have developed multiple genome-scale CRISPR perturbation libraries. Our group also has close access to mass spectrometry, flow cytometry, NGS and animal facilities. Overall, this scientific environment offers rigorous training opportunities in multiple disciplines.
Application Deadline: Open Until Filled
48. Post-doctoral Fellow – Nucleic acid vaccine, immunology, cancer immunotherapy
Summary of Postdoctoral Fellowships:
Postdoctoral training positions are currently available in the Vaccine Branch, CCR, National Cancer Institute, in Frederick, MD. The positions are in the group headed by Barbara K. Felber, Ph.D., whose lab focuses on nucleic acid vaccines against AIDS and COVID-19 and on cytokines for vaccine and cancer.
Application Deadline: Open Until Filled
49. Post-doctoral Fellow – Neurotrophin, trk receptor, mouse models
Summary of Postdoctoral Fellowships:
The Mouse Cancer Genetics Program, CCR, NCI (Frederick, MD) is now recruiting a postdoctoral fellow. The successful candidate should have a background in neurobiology and/or physiology and basic expertise in molecular biology, cell biology, immunohistochemistry, biochemistry and imaging. Candidates with expertise in electrophysiology are also encouraged to apply. Our group studies the biology of neurotrophin and Trk receptor’s function by using both in vitro and in vivo approaches. The current research emphasis is on understanding the molecular mechanisms underlying Trk receptor’s physiological functions. In addition, we are attempting to identify new signaling pathways activated by truncated Trk receptors.
Application Deadline: Open Until Filled
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50. Post-doctoral Fellow – Translational control
Summary of Postdoctoral Fellowships:
Funded postdoctoral fellow positions are available in Dr. Colin Wu’s lab within the RNA Biology Laboratory at the National Cancer Institute (NCI) in Frederick, MD at the National Institute of Health (NIH). The major focus of the laboratory is to investigate the molecular mechanisms of translational regulation and non-canonical functions of the ribosome in mammalian systems. Multiple projects are available: (1) developing and applying high-throughput sequencing approaches to characterize in vivo dynamics of the ribosome and RNA-binding proteins; (2) exploring non-canonical functions of the ribosome in signal transduction; (3) characterizing local translation-coupled RNA decay and protein quality control. The positions offer rigorous training opportunities in multiple disciplines to build a new high impact research program. Visit our website for more information: https://ccr.cancer.gov/staff-directory/colin-wu.
Application Deadline: Open Until Filled
51. Post-doctoral Fellow – Chemical biology, antibody discovery
Summary of Postdoctoral Fellowships:
The Gildersleeve laboratory, Chemical Biology Laboratory (CBL), CCR, NCI has an opening for a postdoctoral fellow. The goal of our research program is to develop and investigate carbohydrate-binding antibodies for cancer applications. We use glycan microarray technology as well as chemical, biochemical, and molecular biology approaches to design and develop new carbohydrate-binding antibodies as research tools, diagnostics, and therapeutics. This project will involve developing new strategies for design and discovery of anti-carbohydrate antibodies for cancer applications. Candidates with experience in antibody development and discovery, protein engineering, glycobiology, and/or directed evolution are especially encouraged to apply.
Application Deadline: Open Until Filled
52. Post-doctoral Fellow – Proteomic instability, HSF1, cancer
Summary of Postdoctoral Fellowships:
Dr. Chengkai Dai’s laboratory at the Mouse Cancer Genetics Program, CCR, NCI, has one postdoctoral fellowship (visiting fellow) position open. The candidate will participate in projects that elucidate proteomic instability of cancer (particularly, tumor-associated amyloidogenesis) and anti-amyloid effects of HSF1. HSF1, the master transcriptional regulator of the heat-shock or proteotoxic stress response, plays a critical role in preserving proteomic stability under stress conditions. Contrasting with its dispensability for primary cells, cancerous cells become dependent on HSF1 for their growth and survival, a phenomenon referred to as “non-oncogene addiction”. Revealed by Project Achilles, numerous human cancer cell lines depend on HSF1.
Application Deadline: Open Until Filled
53. Post-doctoral Fellow – Lymphoma biology, B cell immunology
Summary of Postdoctoral Fellowships:
We are seeking highly motivated Ph.D. graduates for a postdoctoral fellow position in the laboratory of Dr. Jagan Muppidi in the Lymphoid Malignancies Branch, CCR, NCI. The focus of our laboratory is to discover factors promoting the development of aggressive B cell-derived malignancies in vivo through the development of novel mouse models of lymphoma (Razzaghi et al. J. Exp. Med. 2021; Albright et al. J. Exp. Med. 2019; Muppidi et al. Nature 2014). The lab offers many excellent training opportunities including the use of CRISPR to interrogate gene function in vivo, next-generation sequencing, flow cytometry, confocal imaging and cellular immunology. In addition, there are ample opportunities for collaborative work within the branch for both translational and bench research within the labs of Drs. Louis Staudt and Ryan Young, as well as within the NIH community at large. The position is fully funded by an intramural NIH fellowship with competitive salary and benefits. Applications for outside fellowships are encouraged and will be supported.
Application Deadline: Open Until Filled
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54. Post-doctoral Fellow – Tumor metabolism, cancer biology
Summary of Postdoctoral Fellowships:
A fully funded postdoctoral position is available immediately in the lab of Christine Heske (Translational Sarcoma Biology Section) of the Pediatric Oncology Branch (POB), Center for Cancer Research, National Cancer Institute, Bethesda, MD. Our overall research focus is to identify and validate novel therapeutic targets related to tumor metabolism and DNA damage response in pediatric-type sarcomas, a collection of cancers lacking effective treatment options. Our recently published studies have highlighted the translational relevance of targeting specific metabolic pathways in sarcoma. (For examples of our recent work, please see https://pubmed.ncbi.nlm.nih.gov/31431459 and https://pubmed.ncbi.nlm.nih.gov/32908120).
Application Deadline: Open Until Filled
55. Staff Scientist – Pediatric oncology, imaging
Summary of Postdoctoral Fellowships:
The Pediatric Oncology Branch (POB), CCR, NCI, NIH invites applicants for a full-time staff scientist position. This position is for a highly motivated individual with expertise and focus on imaging and image analysis on preclinical and clinical trials for pediatric and adult benign and malignant solid tumors. The POB is a vibrant, multidisciplinary research community conducting innovative, high-impact bench-to-bedside research and close collaboration between physicians and scientists with a primary focus on pediatric and young adult cancers. The POB directs an active clinical trials program translating innovative clinical trials with novel endpoints and outcome measures for children and adults with tumors of unmet need.
Application Deadline: Open Until Filled
56. Post-doctoral Fellow – Cancer, drug development, radiopharmaceuticals
Summary of Postdoctoral Fellowships:
Come join our friendly, collaborative group and help change the way we diagnose and treat patients with cancer! Our group, the Laboratory of Molecular Radiotherapy in the Molecular Imaging Branch (MIB) at the CCR, NCI is seeking a creative, a motivated postdoctoral fellow interested in working at the interface of diagnostics and therapy of human cancers using radiopharmaceuticals. Our work spans tumor-specific target identification, engineering biomolecules to targets of interest, leveraging molecular biology and chemistry to generate novel tumor-targeted imaging and therapeutic probes, and subsequent evaluation of engineered agents in vitro and in vivo, with the goal of clinical translation.
Application Deadline: Open Until Filled
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