University of Cambridge, England invites online application for multiple fully funded PhD Programs in various research areas. Candidates interested in fully funded PhD positions can check the details and may apply as soon as possible.
1. PhD Programs in Contextually Adaptive Mixed Reality User Interfaces
Summary of PhD Positions:
This project seeks to provide a structured and effective method for dynamically adapting mixed reality user interfaces to be most suitable for the current context of use. Context here is treated broadly and may refer to physical location context, task context, and user capability context. Such adaptations must be smooth and preserve awareness of interface elements to ensure productive and enjoyable interaction experiences. Contextual adaptation of interfaces is further complicated in multi-user settings where adaptations may need to consider the context of many users at the same time while delivering a common and consistent shared experience for all users. These requirements for contextual adaptation are unique to mixed reality use cases given the spatial and embodied nature of interactions.
Application Deadlines: 10 February 2023
2. PhD Programs in Micro-Mechanical Testing of Metals with Architected Microstructure
Summary of PhD Positions:
The goal of this project is to investigate the mechanical behaviour of metal alloys with architected microstructure produced using additive manufacturing (AM) technology. Beyond manufacturing of parts with complex geometry, AM is inspiring new designs of materials with spatially varying microstructure. These unique microstructures are attainable by tuning the AM process parameters site-specifically. Following this strategy, a single component may therefore be designed with complex geometry and multiple distinct microstructures, each chosen to best suit the constraints at a given point. A major application of this new paradigm is to produce materials with site-specific mechanical properties.
Application Deadlines: 31 January 2023
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3. PhD Programs in Advanced surface engineering with digital fabrication techniques
Summary of PhD Positions:
Large glass products are manufactured around the world, including in the UK, using the float glass technique and are shipped globally to be found in many sectors, such as automotive and architectural. These are functionalised with nanoscale layer deposition techniques to create antimicrobial, anti-reflection, or conductive surfaces before the glass is then formed into curved shapes. Current manufacturing of float glass and advanced coatings is highly efficient with continuous production. This research focuses on late-stage functional customisation of products, exploring nanoscale precision direct-writing techniques needed for the embedding of sensors, conductive tracks and interconnects and enabling the smart glass materials of the future.
Application Deadlines: 28 February 2023
4. PhD Programs in Underground Digital Twins for Future Tunnelling
Summary of PhD Positions:
A substantial amount of underground construction, much of it in urban environments, is planned in the UK for the coming decades. This includes major projects such as High Speed 2 (estimated £107 billion) as well as transport upgrade projects such as the Bakerloo Extension (£2.57 billion). Given the current economic climate and the UK’s current progress on the Net-Zero agenda, we urgently need new ways to deliver this infrastructure in a way that is low-cost, efficient and sustainable. In partnership with start-up hyperTunnel Ltd, University of Cambridge will deliver a key enabler, namely underground digital twins, of future tunnelling operations to alleviate these pain points.
Application Deadlines: 31 January 2023
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5. PhD Programs in Systematic flow manipulation in wind-turbine arrays
Summary of PhD Positions:
The objective of wind turbine arrays design is ultimately to minimize the levelized cost of electricity over its lifespan. The objective of this project is: (i) to derive a fundamental understanding of the fluid dynamical constraints on the scale of the array that limits its performance, (ii) to translate this understanding into a technology that relaxes or modifies the fluid dynamical constraints, (iii) to determine experimentally and rationalize theoretically the fundamental performance characteristics underlying any proposed technology, (iv) to estimate the improvement to the levelized cost of electricity resulting from the proposed technology.
Application Deadlines: 28 February 2023
6. PhD Programs in Closing the Performance Gap
Summary of PhD Positions:
The project will investigate techniques for ‘learning from data’ and adapting energy models of recent multi-unit residential buildings in real-time for efficient use of energy and to maximise occupant health. These models will be transferrable to predict the behaviour of future buildings under climate change scenarios. The models will be designed to quantify uncertainties in predictions and translate these into risks of not meeting design specifications for fabric efficiency, overheating, energy, and water usage.
Application Deadlines: 15 March 2023
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7. PhD Programs in Higher Education Access
Summary of PhD Positions:
The principal aim of this studentship is to explore higher education applications made, and offers received, by individual applicants and how these relate to subject choice at A-level and the teacher-predicted and actual educational attainment of applicants. Within that, the studentship will also explore the influence of richly-defined socio-economic background on subject choice, predicted and actual grades, and higher education applications.
Application Deadlines: 28 February 2023
8. PhD Programs in PARP1 inhibition and microenvironment in glioblastoma
Summary of PhD Positions:
Glioblastoma (GBM) remains uniformly and rapidly fatal, and a leading cause of life years lost to cancer. Tumour cells recruit a microenvironment rich in Tumour Associated Macrophages (TAMs). TAMs adopt characteristic tumour-permissive states, offer trophic support to tumour cells, and suppress recruitment and activation of immune effector cells, contributing to the failure of immunotherapy. In this context, the clinical response to immune checkpoint blockade and adoptive T-cell therapy in GBM fall far short of that achieved in other solid organ tumours.
Application Deadlines: 31 January 2023
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9. PhD Programs in myeloid checkpoint inhibitors
Summary of PhD Positions:
Checkpoint inhibitors targeting inhibitory molecules on T cells (PD1, CTLA4) to reinvigorate tumour killing, have had great clinical success in some cancers but not others, and even in those cancers with good responses, 60-80% of patients fail to respond. Myeloid cells are a major component of the tumour microenvironment, and can be either pro- or anti-tumourogenic. Therefore, one major strategy being developed is myeloid checkpoint inhibition which, combined with traditional checkpoint inhibitors, may release T cell killing and expand the proportion of responsive patients.
Application Deadlines: 31 January 2023
10. PhD Programs in Inflammatory Bowel Diseases
Summary of PhD Positions:
We are looking for a highly motivated and enthusiastic individual capable of thinking and working independently. The ideal candidate has a strong background in, and exceptional enthusiasm for, computational biology and machine learning, as well as a strong interest in the underlying biological processes and disease mechanisms. We are looking for a person who can work as part of a multi-disciplinary team who has a passion for data driven science. It is expected that the PhD student would spend time in the Zilbauer lab to learn an in-depth working knowledge of the biological and experimental hypotheses, while developing and applying cutting-edge computational approaches in the Han lab to systematically analyse the multimodal datasets.
Application Deadlines: 31 January 2023
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11. 06 PhD Programs in Small Animal Studies
Summary of PhD Positions:
Junior Clinical Training Scholars will receive training and tuition as they rotate through anaesthesia, cardiology, diagnostic imaging, orthopaedics, dermatology, ophthalmology, internal medicine, neurology, oncology, clinical pathology and soft tissue surgery and be supervised by recognised specialists in each field. Scholars will also have responsibility for primary care cases seen at the hospital’s charity clinics, and be involved in supervision and guidance of final year veterinary students. Scholars will be an integral part of the out of hours care of animals within the hospital, especially within the intensive care unit.
Application Deadlines: 5 February 2023
12. PhD Programs in Machine Learning and Computer Vision for Video Modelling
Summary of PhD Positions:
Deep learning has revolutionised many areas of image processing and understanding, allowing for e.g. object segmentation, classification, object tracking, sentiment analysis. However, analysis of video footage and scenes is more niche and there are many open areas of research. In this project we are focussing on analysing 3D scenes in the context of existing video footage. For example, automatically identifying the sentiment of a scene (is it happy or sad), identifying the light sources, tracing of light rays in a scene to understand how occlusions will impact the scene, modelling depth in the scene and tracking of cameras/objects in 3D space.
Application Deadlines: 31 January 2023
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13. PhD Programs in Structure and Mechanisms of Drug Markets
Summary of PhD Positions:
The studentship will be a three-year doctoral programme and will be supervised by Dr Paolo Campana, Associate Professor in Criminology and Complex Networks. ESRC DTP students will acquire a unique set of skills that will equip them for high-profile careers as leading social scientists, in academia or in other government, industrial, commercial and third sector organisations, either in the UK or elsewhere. The project will involve analyzing administrative records from the Criminal Justice System Linked Datasets (part of the UK ADR Data First Project) to explore the structure of drug trafficking in England and Wales as well as the mechanisms underpinning drug markets and the behaviour of their participants.
Application Deadlines: 14 February 2023
14. PhD Programs in Delivering energy retrofits of buildings through integrated optimization of glazing systems
Summary of PhD Positions:
The principal objective of this project is to optimize responsive glazing systems for retrofitting buildings. The optimization will consider glazing systems as a connected intelligent component of a wider and integrated retrofit strategy, and optimize for cost, operational energy savings, embodied carbon, and human comfort. A second objective is to investigate the concept of ‘intelligence through glass’ and ‘transparent intelligence’ with respect to enabling technologies (eg. electronic interaction and sensing capability in conjunction with Artificial Intelligence) in the context of energy retrofitting.
Application Deadlines: 15 March 2023
15. PhD Programs in Future proofing roads digital twins
Summary of PhD Positions:
The research aims to provide the needed geospatial reference model for digital twins enhancing reality capture, 3D reconstruction, asset certainty, and overall spatial context and understanding via integration with existing national data holdings. The reference model must be able to ensure that digital twins can integrate with existing software while offering a flexible enough approach safeguarding backwards compatibility in the future. This project can significantly strengthen the level of maturity (complexity and connectedness) of digital twins enabling the next generation of smart applications, such as performance optimisation by real-time data capture, failure prediction and future scenario modelling.
Application Deadlines: 16 May 2023
16. PhD Programs in Sensor-driven durable low carbon concrete infrastructure
Summary of PhD Positions:
The project is funded in collaboration with National Highways, a government-owned company charged with setting highways standards, operating, maintaining and improving motorways and major A roads in England. One of the major challenges we face in our efforts to maintain the functionality and resilience of our current infrastructure is corrosion. Steel corrosion is the largest and most costly deterioration problem in reinforced concrete, with a UK annual budget of >£1 billion. National Highways are responsible for corrosion protection of reinforced concrete structures on the road network. Very early stage detection of reinforcement corrosion would provide significant benefits in protecting existing assets and optimising maintenance regimes.
Application Deadlines: 16 May 2023
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17. PhD Programs in Sensor development
Summary of PhD Positions:
Early fault detection and maintenance can significantly improve the lifespan of expressways. The student will first investigate different sensing modalities (acoustic, optical and electromagnetic, etc ) and their feasibility in the given application with project partners. Characterization and modelling of individual sensors will then be performed. Optimal distribution and placement of the sensors will be studied to reduce production cost and maintain robustness to damage. Data-driven algorithms for detecting and differentiation onset of damage from normal load conditions will be developed. Finally, the framework will be tested in real-world conditions and possibly extended to other application domains.
Application Deadlines: 16 May 2023
18. PhD Programs in How much CO2 can we sequester within our roads?
Summary of PhD Positions:
The project is funded in collaboration with National Highways, a government-owned company charged with setting highways standards, operating, maintaining and improving motorways and major A roads in England. The UK Net Zero Highways document has set a target of net zero emissions for construction and maintenance by 2040. The materials deployed in the construction and repair of roads (asphalt, concrete, reinforcement, aggregates, repair grout, sealants etc) are a significant contributor to carbon emissions. While there are many initiatives targeted at reducing those emissions with the use of low carbon materials, there are also many exciting opportunities to augment this with further carbon sequestration technologies and strategies to further drive down the carbon footprint with the ultimate goal of going beyond net zero.
Application Deadlines: 16 May 2023
19. PhD Programs in 3D printing for smart pavement applications
Summary of PhD Positions:
The National Highways Digital Strategy includes a roadmap committing to deliver significant digitalisation of the strategic road network by 2025. This commitment is paving the way for a range of innovative and impactful autonomous, robotic, remote and smart delivery approaches. 3D printing has emerged as a technology with huge potential to transform the way we construct and maintain our infrastructure assets in a smart, cost-effective, resource-efficient and sustainable fashion. Advanced 3D printing techniques would enable the delivery of multiple materials (e.g. bituminous, cementitious and polymeric), with different compositions, including low carbon alternatives, with very different properties and with additives such as fibres and sensors; composite materials with complex functional architectures and precast and in-situ elements for road construction and maintenance applications.
Application Deadlines: 16 May 2023
20. 02 PhD Programs in Domestic retrofit as a challenge of high volume manufacturing
Summary of PhD Positions:
All of the UK’s 28 million homes must be retrofitted to the highest levels of energy performance in the 28 years remaining to deliver the UK’s legal commitment to zero emissions. A small number of expensive and slow one-off projects have demonstrated that this can be done, with Victorian buildings retrofitted to performance near to thatof new Passiv Houses. However the costs of these projects has been very high and they have taken a long time. Converting from expensive one-off delivery to mass market coverage requires that we deploy the design and production skills and technologies of contemporary manufacturing to the practices of one-off small-scale construction.
Application Deadlines: 16 May 2023
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21. PhD Programs in Smart Microbes for sustainable and resilient land regeneration
Summary of PhD Positions:
The project is funded in collaboration with major UK design and build environmental contractor, McAuliffe Group and its specialist technical soils and groundwater remediation arm, Geostream UK Natural and engineered microorganisms have played a significant role in recent academic and commercial approaches for the treatment of damaged land. These approaches have included ground improvement, via biomineralisation through microbial-induced calcite precipitation (MICP), bioremediation via sorption and/or precipitation processes, and biological self-healing within the MICP environment. Those approaches have so far been mainly researched or applied in isolation to meet different design requirements and deliver different outcomes.
Application Deadlines: 16 May 2023
22. PhD Programs in Modular Basements
Summary of PhD Positions:
This project will bring about a step-change in basement design and construction through the use of modular off-site elements which are designed for rapid ‘jigsaw’ assembly on site. Modularised liner walls will be designed to work compositely with retaining walls for structural optimisation. The faster assembly/installation times on site and the greater flexibility for installation will pave the way for a new ‘just-in-time’ approach to basement construction: articulated jigsaw raft elements will only be fully ‘engaged’ as a final step to minimise locking in heave-induced pressures.
Application Deadlines: 16 May 2023
23. PhD Programs in Digital Basements
Summary of PhD Positions:
Urban basement construction is an increasingly challenging and high-risk activity. As the industry is forced to reuse old inner-city foundations, monitored structural health will be become critical: (a) to make a convincing case for reuse and (b) to inform the design of the new superstructure. For the first time, this PhD project will develop digital twins for basements to enable design and construction optimisation. The project will develop autonomous connections between 3D design models, structural (e.g. finite element) models and state-of-the-art real-time site monitoring. Close collaboration with industry partner Laing O’Rourke will enable uncertain parameters in the design process to be identified. This will inform an optimal site monitoring layout to target these uncertainties.
Application Deadlines: 16 May 2023
24. PhD Programs in Mechanical Behaviour of Artificially Frozen Ground
Summary of PhD Positions:
The project is funded in collaboration with Geotechnical Consulting Group. GCG provides expert advice by applying the sciences of soil, rock mechanics and engineering geology to civil engineering design and construction, and to the preservation and enhancement of the environment. The applications of artificial ground freezing in construction cover the formation of frozen earth walls to support deep excavations, structural underpinning for foundation improvement, and temporary control of ground water. The growing awareness of the merits of artificial ground freezing as a temporary ground improvement system with minimal environmental impact is directly related to progress in the understanding of the mechanical behaviour of frozen soils.
Application Deadlines: 16 May 2023
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25. PhD Programs in Performance – Based Concrete as a Route for CO2 reduction
Summary of PhD Positions:
Cement production is responsible for 5-7% of man-made CO2 emissions. A rapid transition to lower carbon concrete is an imperative and the pathway relies on the urgent implementation of performance-related thinking. Design, procurement, performance and standards are intrinsically inter-linked and are key enablers individually and collectively. A robust digital evidence base for accurate prediction and measurement of concrete performance coupled with strategies to incentivize performance based design are fundamental strands to overcome the challenges of lower carbon concretes.
Application Deadlines: 16 May 2023
26. PhD Programs in Net-zero Energy Retrofits At Scale
Summary of PhD Positions:
This project will quantify domestic net-zero transitions under uncertain climate futures for adaptation and mitigation using stochastic models. The model will be used to generate future scenarios of land use, environment, and energy use across the city that are sufficiently plausible to inform decision-making. Approaching building emission modelling through a trans-disciplinary lens, this project will harness new data sources and data science methods to model the impacts of retrofit technologies on energy equity as well as net-zero objectives. The models will be tested in terms of their computational tractability, reproducibility, and usability. Finally, the project will investigate new effective forms of communicating stochastic outputs in forms that can be understood by decision-makers.
Application Deadlines: 16 May 2023
27. PhD Programs in Display Image Quality
Summary of PhD Positions:
Our group consists of PostDocs and PhD students investigating ways in which computer vision, computer graphics and signal processing can be improved by incorporating the models and knowledge of human vision. The group consistently publishes their work at premium computer graphics and vision venues, such as SIGGRAPH, CVPR, ECCV, IEEE TIP. The position is within the Graphics & Interaction Group (Rainbow) of University of Cambridge’s Department of Computer Science and Technology, a vibrant and internationally leading environment. Collaboration with researchers at other universities and industries around the world is encouraged and there are strong links within the group with local, national and international companies.
Application Deadlines: 17 February 2023
28. PhD Programs in toxicity of nucleic acid therapeutics
Summary of PhD Positions:
Cardiac diseases are a leading cause of morbidity and mortality. Treatment of heart failure is currently limited to a small class of therapeutics that do not reverse the cardiac phenotype or prevent the development of heart failure (HF). Cardiac targeted nucleic acid therapies (NATs) could unlock novel therapeutic avenues to treat, reverse and even prevent HF. As emphasised by drug-induced cardio-toxicity in the oncology field, novel therapies have to be safe both acutely and chronically. Current safety concerns around NATs focus on the liver and/or immune system due to their high systemic exposure. However, as future NATs are developed to actively target the heart and increase cardiac exposure, safety is likely to become an increasing concern.
Application Deadlines: 31 March 2023
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29. PhD Programs in Systems Biology of cellular response to environmental chemicals
Summary of PhD Positions:
Substances used as food additives, therapeutics or cosmetic ingredients elicit cellular responses at transcriptional and post-transcriptional level. The outcome of the response is either adaptive, when cells modify their gene expression program to survive during adverse conditions, or adverse, when cellular changes impair their function leading to detrimental impacts of the chemical. The decision to mount an adaptive or adverse response is key cell-fate decision with conceptual parallels to developmental biology (see references). Nonetheless the mechanistic basis of the adaptive versus adverse decision is not fully elucidated, which forms the basis of the proposed project.
Application Deadlines: 31 March 2023
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30. PhD Programs in Regulation of human tRNA metabolism during stress and diseases
Summary of PhD Positions:
Human cells are constantly exposed to environmental stress. We have evolved elaborate mechanisms to mount appropriate response to adapt to the stress. The transcriptional branch of the stress response has been intensely investigated focussing primarily on protein-coding genes. Our current work has identified that tRNA synthesis is highly regulated during stress. How stress affects RNA Polymerase III that transcribes tRNA remains unknown We have conducted genome-wide CRISPR-Cas9 screen and identified several trans-regulators of this process. The project will investigate how these trans-regulators communicate with stress-signalling pathway and how the pathway is modified in cancer and neurodegeneration with the hope of identifying therapeutics.
Application Deadlines: 31 March 2023
31. PhD Programs in Mitochondrial Toxicity in Idiosyncratic Drug-induced Liver Injury (iDILI)
Summary of PhD Positions:
In drug development, Drug-induced liver injury (DILI) is a serious ADR, and a common driver of drug attrition in phase I-III trials across therapeutic areas (Weaver et al. 2021). Idiosyncratic drug-induced liver injury (iDILI) is one of the most challenging diagnosis in clinic & drug development. In this project, we will build on our initial evaluation in collaboration with AstraZeneca of idiosyncratic DILI patient-derived MetaHep cells as a pre-clinical model to enable better understanding of the role of mitochondrial toxicity in iDILI.
Application Deadlines: 31 March 2023
32. PhD Programs in Impact of microbiome metabolism on drug-induced toxicity
Summary of PhD Positions:
The efficacy and side effects of various drugs have been linked to the gut microbiome. Gut bacteria also directly modify and bioaccumulate several drugs altering their pharmacokinetics/pharmacodynamics. This project will focus on drug toxicity through the angle of the liver-gut axis which is driven by two-fold interactions between these organ systems, viz., drug co-metabolism through entero-hepatic circulation, and impact of gut bacterial metabolites on tissue function. The student will have a unique opportunity to work in this emerging field of microbiome-host interactions from a mechanistic angle. They will work closely with members of the Patil and Aitken lab as well as with AstraZeneca to gain insights into translational toxicology research.
Application Deadlines: 31 March 2023
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33. PhD Programs in Developing novel single-cell sequencing methods for identification of immunotoxic B lymphocytes
Summary of PhD Positions:
In this Ph.D the student will develop novel methods for immune repertoire sequencing of B lymphocyte populations and benchmark this against existing 10x genomic methods. They will do this in terms of both murine and human B cell populations and apply this to samples collected from patients or from preclinical models of toxicity. The project is conducted in collaboration with the Centre for Drug Safety Science, University of Liverpool.
Application Deadlines: Open until filled
34. PhD Programs in blood donor health
Summary of PhD Positions:
One aim of the BTRU – Safety of Blood Donation – is to make donation safer by developing and evaluating novel strategies to mitigate adverse health effects of blood donation and maintain donor health. This aim will be achieved by leveraging existing data resources, new qualitative studies and proof-of-concept trials. Specific short-term aims are to evaluate and develop strategies to prevent adverse health effects of blood donation and identify subgroups of donors more likely to benefit from preventive strategies.
Application Deadlines: 31 March 2023
35. PhD Programs in Exploring the Molecular Architecture of FADD
Summary of PhD Positions:
Following exposure to drugs or environmental agents, several large multi-protein signalling platforms play a key role in determining cell death or survival. Caspase-8, a key regulator of cell fate, is recruited/activated within these complexes. Despite these signalling platforms playing a role in determining the tissue response to toxic insult the mechanisms underlying their assembly and regulation is still poorly understood. Overall this project will provide novel insights into the co-ordinated control of life/death decisions by FADD:Caspase-8 signalling platforms including the DISC, Necrosome and Ripoptosome, thereby increasing our understanding of the cellular response to toxic injury.
Application Deadlines: 31 March 2023
36. PhD Programs in Direct identification of the antigenic triggers for immunotoxic T lymphocytes
Summary of PhD Positions:
Immunotherapy toxicity is mediated by the activity of T lymphocyte clones that are driven by specific antigenic targets. In this project the student will use mouse and human samples to identify candidate T cell antigens that drive these maladaptive immune responses. These results will determine how changes in transcription caused by immunotherapy can change the display of antigen, and the potential this has for triggering tissue-damaging T cell responses. These results will determine how changes in transcription caused by immunotherapy can change the display of antigen, and the potential this has for triggering tissue-damaging T cell responses.
Application Deadlines: 31 March 2023
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37. PhD Programs in Magnetic resonance imaging
Summary of PhD Positions:
Applications are invited for 3.5-year PhD studentship based in the Department of Chemical Engineering & Biotechnology, University of Cambridge and the new AstraZeneca Discovery Centre at Cambridge. The student will be working on a collaborative project jointly supervised by Prof Mick Mantle in The Department of Chemical Engineering & Biotechnology and Dr Richard Storey and Dr Les Hughes at AstraZeneca and will have the opportunity to work across the two sites. The project is in the field pharmaceutical/ biopharmaceutical development that has generated much excitement in both academia and industry.
Application Deadlines: 31 January 2023
38. PhD Programs in Machine Learning
Summary of PhD Positions:
The rapid development of deep learning techniques in recent years enables the increasing utilisation of computer-aided detection (CAD) tools in assisting radiologists with their workflows and clinical diagnosis. In contrast to human medicine, the use of CAD and AI with veterinary studies is minimal and much less explored with its power yet to be exploited. The aim of the project is firstly to develop an AI-based tool to automatically detect, and segment anatomical body areas included in an animal CT scans. Secondly to further develop the tool to allow triage of the clinical cases based on AI recognition of specific imaging features. This project will also involve curation for the clinical and imaging data along with application and development of new techniques for pattern recognition (deep learning), image synthesis and domain adaptation.
