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13 Postdoctoral Fellowships at VIB-KU Leuven, Belgium

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VIB-KU Leuven, Belgium invites multiple online application for Postdoctoral Fellowships in various research areas. Candidates interested in Postdoctoral Fellowships can check the details and may apply as soon as possible.

1. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

We seek a talented and creative postdoctoral scholar to study neural circuits of vision with focus on motion processing and visuomotor behaviour in mice using state-of-the-art methods. The project builds on large a large array of functional cellular imaging and connectivity data that were acquired in mouse cortical and thalamic visual pathways (Han et al 2020). The goal is to delineate cortical and subcortical circuits responsible for encoding and tracking of visual objects. The project will involve advanced behavioral assays, patterned light optogenetics and large-scale recordings.

Application Deadline: Open Until Filled

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2. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The UMSTI studies the molecular and cellular mechanisms that control inflammation and immunity. In the frame of the EOS (Excellence of Science) funding programme we have recently initiated the BRIDGE project (Taking IBD Genes from GWAS to Function to Drug Target). BRIDGE brings together scientists from 4 different Belgian universities and 1 US lab with complementary expertise in genomics, immunology, cell biology, and clinical gastroenterology to jointly develop a pipeline to systematically interrogate IBD-relevant functions of GWAS-identified candidate genes relevant to disease activation and recurrence.

Application Deadline: Open Until Filled

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3. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The research team of Prof. Mathieu JM Bertrand has a vacancy for a highly motivated postdoctoral scientist with research experience in autophagy, cell death, and/or inflammation. The successful candidate will be responsible for studying mechanisms of autophagic degradation and its interplay with inflammation and cell death modalities, using cells of human and murine origin and mouse models of inflammatory diseases. This research is part of the iBOF ATLANTIS project (Autophagy in inflammation and inflammatory disorders, from basic insights to experimental therapy). ATLANTIS brings together scientists with complementary expertise in the fields of autophagy, cell death, inflammation, angiogenesis, and drug screening/medicinal chemistry.

Application Deadline: Open Until Filled

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4. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Due to the development of resistance to antibiotics, bacterial infections are becoming more life-threatening every year. In addition to resistance, bacterial persistence offers an important means to avoid clearance of infections. Persisters are formed by phenotypic switching to an antibiotic-tolerant state, rendering a small subset of cells within an isogenic population capable of surviving antibiotic treatment.

Within this ongoing research project we want to gain more insight into the mechanisms of persistence by unravelling the associated molecular pathways down to atomic resolution (e.g. Verstraeten et al. Mol. Cell 2015; Gkekas et al. J. Biol. Chem. 2017; Verstraeten et al. Mol. Microbiol. 2019).

The project is part of an interdisciplinary Excellence of Science program in collaboration with the teams of Jan Michiels, Régis Hallez, Françoise Van Bambeke, Steven Ballet and Jörg Vogel. Within this consortium you will use single particle cryo-EM and X-ray crystallography, in combination with biophysical methods and enzyme kinetics, to gain insight in the role of important persistence proteins and their interactions. This information will subsequently be used to intervene with these proteins and processes to devise new potential therapeutic strategies.

Application Deadline: Open Until Filled

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5. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

A fully funded Postdoc position is available in the lab Structural & Molecular Microbiology at VIB – Vrije Universiteit Brussel, Belgium, to work on an FWO project studying the nucleation, cross-reactivity, and structure of bacterial functional amyloids (FA). Amyloids are aggregative protein or peptide fibrils best known for their implication in a range of neurodegenerative illnesses.

The self-assembly into cross-Ăź-structured fibrils is however not restricted to the off-pathway protein misfolding events, but also found as the native conformation of a wide range of pro- and eukaryotic proteins referred to as FA. FAs produced by prokaryotes are often related to the persistence and virulence of bacterial biofilms. Despite their importance, little is known regarding the FA ultrastructure and their mechanism of formation.

Application Deadline: Open Until Filled

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6. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Laboratory for Mechanisms of Cell Transformation, headed by Professor Anna Sablina, is a pioneer in the investigation of cooperative interactions promoting human disease. To achieve this, we have taken a multi-faceted approach by combining mouse modelling with comprehensive CRISPR-based techniques and multi-omics approaches.

The results of our studies have been published in multiple high-profile journals including Science, Cancer Cell, and Nature Cell Biology. Our current research is aimed to decipher the proteostatic regulation of the RAS GTPases and their relevance to human health and disease. Our final goal is to identify specific therapeutic targets regulating RAS biology, that could be drugged for personalized therapy in cancer patients.

Application Deadline: Open Until Filled

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7. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Our research goal is to unveil how key cell-fate decision networks in cancer cells and stromal cells model the tumor microenvironment, antitumor immunity, and inflammation. We focus on key molecular mechanisms regulating cancer cell death, cancer-driven lymphangiogenesis, and T-cell responses controlling antitumor immunity, which can be harnessed to improve the efficacy of immunotherapy or new therapeutic approaches against melanoma.

We are particularly interested in understanding how rewiring of crucial homeostatic/metabolic pathways enables melanoma cells to resist spontaneous or therapy-induced cell death, and disseminate through the lymphatic system and the lymph nodes while escaping immunosurveillance.

Application Deadline: 28/02/2023

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8. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The research of Prof. Peter Carmeliet focuses on the development of blood vessels (angiogenesis) and vascular heterogeneity in health and disease, with the ultimate aim to identify novel therapeutic vascular-based strategies. Current anti-angiogenesis therapies (AATs), by targeting the pro-angiogenic factor VEGF, suffer resistance and insufficient efficacy.

The Carmeliet lab explores opportunities to overcome these limitations and to improve AAT by focusing on endothelial cell metabolism, endothelial heterogeneity and in particular, endothelial immunity. Recent projects, combining single-cell transcriptomics with bulk multi-omics (transcriptomics, (epi)-genomics, proteomics & metabolomics) revealed novel insights in endothelial cell metabolism and heterogeneity in health and disease.

The Carmeliet lab is now using these insights to design novel therapeutic strategies, in part to develop an alternative immunotherapy strategy for cancer (based on targeting immunosuppressive mystery genes in ECs) and to develop novel immunotherapies for vascular disorders, characterized by vascular inflammation and EC dysfunction (diabetes, ischemia/reperfusion (also relevant for organ transplantation rejection), etc), based on targeting immunostimulatory genes in ECs.

Application Deadline: Open Until Filled

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9. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Jo Van Ginderachter (JVG) lab is looking for an outstanding postdoctoral scientist interested in understanding how the heterogeneity and pro-tumoral activity of tumor-associated macrophages is regulated and how the manipulation of such regulatory mechanisms can be harnessed to improve immunotherapy.

We are especially interested in understanding how RNA epigenetic alterations sculpt tumor-associated macrophages and affect the tumor-promoting function of these cells in various mouse models of non-small cell lung carcinoma and triple-negative breast cancer, as well as their human counterparts.

This project is embedded within a high profile, excellence-based research consortium (EOS program) of four partners in Belgium (Jo Van Ginderachter-VIB/Vrije Universiteit Brussel, Massimiliano Mazzone-VIB/KULeuven, Pierre Close-Université de Liège and François Fuks-Université Libre de Bruxelles).

While the JVG and MM labs are at the forefront of tumor-associated macrophage research, PC and FF are renowned experts on RNA epigenetics. The postdoctoral scientist will be actively involved in this consortium and will interact and collaborate with the partner labs.

Application Deadline: Open Until Filled

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10. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Laboratory of Sleep and Synaptic Plasticity (PI: Sha Liu) at the VIB-KU Leuven Center for Brain & Disease Research is seeking a postdoctoral researcher to join our group. Our lab employs multi-disciplinary approaches, including Drosophila genetics, quantitative behavior analysis, electrophysiology, in vivo functional imaging, and neural circuit mapping and manipulation, to study the basic mechanisms underlying sleep and its function in the brain at synaptic and circuit levels.

Application Deadline: Open Until Filled

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11. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Laboratory for the Research of Neurodegenerative Diseases, headed by prof. Bart De Strooper is a vibrant environment where key issues related to Alzheimer’s disease are tackled. We are currently looking for a highly skilled and motivated postdoc to join our multidisciplinary project on the cellular response to Alzheimer’s pathology (De Strooper et al, Cell).

In this project, we investigate why some people are protected against Alzheimer’s Disease despite the presence of amyloid plaques. Understanding why some people are resilient to Alzheimer’s disease will help us to identify new drug targets.

The candidate will work on the analysis of human spatial transcriptomics data (using the 10x Visium platform), and integrate this with other data, such as high-resolution in situ sequencing data and single-cell RNAseq from multiple projects and models in the lab to prioritize targets for further drug discovery in a collaboration with our spin-off biotech company Muna Therapeutics.

Application Deadline: Open Until Filled

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12. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Do you want to help find out what is really going on in Alzheimer’s disease? Why does the disease sweep through the brain in such a determined manner? Why do amyloid aggregates form in certain brain regions and not others? Why are some brain regions devastated and others spared?

In our previous work, we have identified a new mode of amyloid interactions based on local sequence similarity to aggregation-prone regions and the National Institute on Aging has just granted us a 5-year project to investigate the interaction of amyloid-beta and tau with other brain region-specific proteins.

Application Deadline: Open Until Filled

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13. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Laboratory of Computational Biology (Stein Aerts lab) at VIB-KU Leuven is seeking a postdoc to join our efforts in deciphering the genomic regulatory code underlying cellular identity, with a focus on the brain.

  • You will develop new AI strategies to learn the genome syntax using large-scale single-cell multi-ome atlases as training data
  • You will unravel the diversity of neuronal cell types in the brain of various species (octopus, birds, mammals) through machine-learning & comparative genomics
  • You will work very closely together with our wet-lab for data generation and experimental validations
  • You will use your AI models to generate synthetic enhancers with new functions, and to functionally interpret non-coding genome variation (health and disease).

Application Deadline: Open Until Filled

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