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22 Postdoctoral Fellowships at St. Jude Children’s Research Hospital, Tennessee

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Are you holding PhD degree and looking for Postdoctoral Fellowships? St. Jude Children’s Research Hospital, Tennessee invites multiple online application for Postdoctoral Fellowships in various research areas. Candidates interested in Postdoctoral Fellowships can check the details and may apply as soon as possible.

1. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Several postdoctoral positions are available in the laboratory of Dr. Victor J. Torres in the new Department of Host-Microbe Interactions at St. Jude Children’s Research Hospital. The Torres lab is interested in dissecting the complex interactions between pathogenic bacteria and the mammalian host. Currently, the lab is focusing on antibiotic resistant (AMR) bacteria, which have been recognized by the World Health Organization as a serious threat to human health. We take advantage of multidisciplinary approaches and combine techniques from bacteriology, genetics, molecular biology, biochemistry, structural biology, cellular biology, and immunology with primary tissue culture models and a variety of murine models of infection, to address our favorite questions. Our ultimate goal is to understand the basic principles of bacterial pathogenesis as well as to develop a platform for the discovery of targets that could be exploited for the generation of much-needed therapies.

Application Deadline: Open Until Filled

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2. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Mittag laboratory invites applications for a Postdoctoral Research Fellow to work on structures of the tumor suppressor and ubiquitin ligase component SPOP. We have recently solved the first cryo-EM structures of full-length SPOP (Cuneo et al. Mol Cell 2023), and they have revealed interfaces that had not recently been observed in structures of smaller constructs. Importantly, these interfaces are lined with cancer mutations whose molecular mechanisms were not previously understood, but now provide molecular explanations for pathophysiological mechanisms. We have also revealed that certain mutations lead to large changes in quaternary assembly. The project provides opportunities for characterizing structures of SPOP complexes with additional ligase subunits and of disease mutants with altered structures.

Application Deadline: Open Until Filled

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3. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

A postdoctoral researcher position is available in Dr. Yong Feng’s laboratory at the Department of Immunology in St. Jude Children’s Research Hospital. Research in Dr. Feng’s laboratory is utilizing innovative approaches and cutting-edge technologies to decipher the mechanisms governing T cell tolerance involved in autoimmunity and anti-tumor immune response. Highly self-motivated candidates with recently granted Ph.D. or equivalent in immunology, genetics, molecular biology, cell or developmental biology are invited to apply. Candidate will be supported by an NIH grant to explore an emerging area in T cell biology. Besides the unmatched benefit for postdoctoral fellows at St. Jude Children’s Research Hospital, the extraordinary internal support and state-of-the-art facilities provide an exceptional environment to train the next generation of immunologists. A cover letter of interest, CV and three recommendation letters should be sent to Yong.Feng@STJUDE.ORG

Application Deadline: Open Until Filled

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4. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Geeleher Lab in the department of Computational Biology is seeking outstanding candidates for fully supported postdoctoral fellowships focused on developing innovative computational and statistical approaches to inform and improve therapies for pediatric cancer and other diseases. One of the premier pediatric research institutions in the world, St. Jude Children’s Research Hospital provides exceptional resources and a supportive environment for career development. As a postdoctoral fellow, you will interact with leaders in cancer and translational research within and outside the institution and at national/international meetings. Innovative research will be supported by the lab’s infrastructure, which includes a wet-lab component. Postdocs have considerable flexibility and freedom to develop their research programs.

Application Deadline: Open Until Filled

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5. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Babu Group uses data-driven approaches to understand sequence-function relationships in intrinsically disordered proteins and structure-function relationships in medicinally important structured protein families such as GPCRs and Kinases, respectively. We are looking for a candidate to fill any of a number of roles in the Group. M. Madan Babu’s Group in the Center of Excellence for Data-Driven Discovery and the Department of Structural Biology is seeking a Postdoctoral Research Associate to develop new interdisciplinary research projects in the group.

Application Deadline: Open Until Filled

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6. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Abraham lab studies gene expression-regulation mechanisms in healthy and diseased mammalian cells. We are recruiting computational biologists to collaboratively develop computational tools and frameworks to analyze high-throughput sequencing (-omics) data. We build analytical software pipelines to find answers to biological questions about gene regulation in big datasets, usually from applied sequencing experiments like ChIP-Seq, RNA-Seq, and Hi-ChIP. Our interests center on enhancers and super-enhancers. Specifically, we seek to understand how these regulatory elements establish gene expression programs in healthy cells, and how enhancers are altered by mutation, abused by mistargeting, and targetable with drugs in diseased cells. We focus on characterizing the core regulatory circuitries driving disease-relevant cells, and on understanding how mutations in the non-coding DNA of such cells can drive disease, including cancers, through gene misregulation.

Application Deadline: Open Until Filled

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7. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

St. Jude is seeking outstanding candidates for postdoctoral fellowship positions in the Childhood Hematological Malignancies Training Program. This prestigious, NIH-sponsored T32 training program leverages the exceptional research infrastructure at St. Jude to train top-tier postdoctoral fellows with the necessary skills to lead independent research programs. Hematological malignancies are the most common childhood tumors, and despite remarkable advances in survival rates, they remain a leading cause of cancer death. The last decade has witnessed significant progress in understanding the genetic basis of these tumors, which now requires systematic efforts to translate the wealth of genomic discoveries into new experimental models and therapeutic advances. Postdoctoral fellows participating in the program will receive training in genomic analysis, experimental modeling, translational science, and preclinical modeling of childhood hematological malignancies.

Application Deadline: Open Until Filled

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8. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

This individual will lead exciting research initiatives, using a multidisciplinary approach that includes cryo-EM, biochemical, biophysical, and cell biological methods, to study the structures and molecular mechanisms of membrane proteins (e.g., Chen et al., Cell 2023; Ye et al., Molecular Cell, 2022). Our lab has full access to the state-of-the-art cryoEM facility at St. Jude, which houses a 300kV Titan Krios, a 200kV Arctica, and a 120kV Talos L120C microscope. We are looking for an individual who has a passion for learning and navigating new research fields, and is comfortable pursuing highly impactful scientific advances. Candidates with experience in protein biochemistry, structural biology or other related fields are encouraged to apply. Excellent communication skills and a collaborative attitude are essential.

Application Deadline: Open Until Filled

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9. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

A postdoctoral fellow position is currently available in the Brady Laboratory, located within the Department of Pharmacy and Pharmaceutical Sciences at St. Jude Children’s Research Hospital, Memphis, TN. The laboratory’s focus is to identify therapeutic vulnerabilities and resistance mechanisms resulting from genomic alterations in pediatric cancer, including osteosarcoma, neuroblastoma, and rhabdomyosarcoma. We seek an accomplished, self-motivated, meticulously organized bench researcher with a strong background in molecular biology and mammalian cell culture techniques. While this position focuses on experimental techniques, candidates will have the opportunity to learn aspects of genomics and computational biology if interested.

Application Deadline: Open Until Filled

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10. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

A postdoctoral research associate position is available in the lab of Dr. Yutaka Yasui. We are seeking a data-scientist postdoc with background in all three areas of biostatistics, epidemiology, and machine learning to work in a collaborative group of childhood cancer survivorship researchers. A PhD degree in one of the three areas with methodological competence in all three areas, expertise in analyzing a large clinical cohort data and clinical-outcome prediction modeling, and collaborative work experience with clinical and population scientists are required. The appointment is for two years initially with a possible extension of an additional year.

Application Deadline: Open Until Filled

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11. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

A postdoctoral position is available in the Derecka Lab in the Department of Hematology at St. Jude Children’s Research Hospital to study transcriptional regulation of the bone marrow niche. The major research goal of our group is to gain mechanistic insights into cellular cross communication between bone marrow microenvironment and hematopoietic compartment, in steady state and pathophysiological conditions. You will have the opportunity to develop new exciting projects involving changes of bone marrow microenvironment and its impact on aging blood system; transcriptional dysregulation of bone marrow niche in hematological disorders and bone marrow niche-induced changes of chromatin landscape in hematopoietic progenitors.

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12. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Dr. Crispino’s laboratory studies the biology of normal and malignant hematopoiesis with an emphasis on the factors that drive progression of benign disorders to acute leukemia. Research in the lab ranges from the basic science of transcription to translational research aimed at developing treatments for blood disorders. A current major focus of the lab is to understand the increased risk of leukemia in children with Down syndrome and the role of GATA1 mutations and DYRK1A in oncogenesis. Another area of intense study is defining the mechanisms by which myeloproliferative disorders and myelodysplastic syndrome progress to acute myeloid leukemia. Finally, there is a major effort to understand the role of GATA1 in erythropoiesis.

Application Deadline: Open Until Filled

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13. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Chen Lab studies: (1) the chemical regulation of transcription, (2) the molecular basis of signal crosstalk among transcription factors, and (3) the mechanism of selective modulation of highly homologous enzymes. We are taking a hypothesis-driven and technology-enabled multidisciplinary approach to develop chemical probes and investigate biological mechanisms. In particular, we use the promiscuous nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) as models. PXR and CAR transcriptionally regulate cytochrome P450 3A4 (CYP3A4) and CYP3A5—drug-metabolizing enzymes that metabolize more than 50% of clinical drugs, the dysregulation of which contributes to drug toxicity and drug resistance.

Application Deadline: Open Until Filled

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14. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Our postdoctoral research associate program invites applicants for a role that combines innovative research in radiation oncology physics and adaptive proton therapy. The selected postdoctoral research associate will contribute to pioneering projects aimed at refining proton therapy techniques and improving outcomes for cancer patients. Our commitment lies in progressing adaptive proton therapy research and facilitating the translation of these advancements into clinical practice.

Application Deadline: Open Until Filled

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15. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Chen Lab studies: i) Chemical modulation of transcription; ii) Signal crosstalk among transcription factors; and iii) Selective inhibition of highly homologous enzymes. We take a hypothesis-driven and technology-enabled multidisciplinary approach to develop chemical probes and investigate biological mechanisms. Particularly we use the promiscuous xenobiotic nuclear receptors (PXR and CAR) as models to investigate the transcription networks that regulate therapeutic responses. PXR and CAR regulate the detoxification system (e.g., by transcriptionally controlling CYP3A4 and CYP3A5—drug-metabolizing enzymes that metabolize more than 50% of clinical drugs), the dysregulation of which contributes to drug toxicity and drug resistance.

Application Deadline: Open Until Filled

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16. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Tsai Laboratory is seeking dynamic and creative candidates for a fully supported postdoctoral fellowship on genome editing technologies for therapeutic treatment of genetic disorders. CRISPR genome editors, adapted from bacterial adaptive immune systems, are transforming both basic biological research and genomic medicine. At St. Jude, we are working toward advancing these technologies towards patient treatments for sickle cell disease and bone marrow failure disorders.

Application Deadline: Open Until Filled

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17. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Immunology postdoctoral positions are available in the laboratory of Dr. Hongbo Chi in the Department of Immunology, St. Jude Children’s Research Hospital. The Chi lab investigates immunobiology and cancer immunology, by focusing on metabolic regulation of the immune system (immunometabolism) and its implications in cancer and other diseases. As metabolic pathways are inextricably connected to immunity and cancer, understanding these connections allows us to gain new insights into biological concepts and disease targets. We are particularly interested in understanding the metabolic programs (e.g. amino acid and lipid metabolism), signaling pathways (e.g. mTOR and nutrient-induced signaling), and systems-level regulatory networks (e.g. protein–protein or driver gene–target gene interactions) that regulate basic T cell and dendritic cell biology and antitumor immunity.

Application Deadline: Open Until Filled

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18. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Research will focus on understanding the genetic basis of antibiotic resistance in Streptococcus pneumoniae as well as mechanistic studies of virulence. The Rosch lab is looking for a postdoctoral scientist with an interest in host-pathogen interactions and/or antibiotic resistance. We are I looking for candidate with a PhD in Microbiology, Molecular Biology, or related field. Ideal candidates will have proven expertise in bacterial genetics, molecular techniques, and/or pathogenesis studies and excellent communication skills. Individuals should have the ability to work collaboratively in a fast-paced research environment. Research will focus on understanding the genetic basis of antibiotic resistance in Streptococcus pneumoniae as well as mechanistic studies of virulence.

Application Deadline: Open Until Filled

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19. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

St. Jude Children’s Research Hospital is committed to the education and training of the next generation of research scientists. St. Jude trainees are able to learn from clinical and basic science investigators who work in close proximity and interact regularly to translate scientific discoveries into improved therapies for children. If you are a highly motivated individual who wants to work at a world-class institution with state-of-the-art facilities and learn from investigators at the forefront of their fields, consider advancing your research training at St. Jude. A postdoctoral position is available at St. Jude Children’s Research Hospital for an outstanding and highly motivated candidate to investigate the innate immune responses against infection.

Application Deadline: Open Until Filled

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20. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Ma Lab in the department of Computational Biology is seeking outstanding candidates for a postdoctoral research associate focused on developing novel computational approaches to understand the molecular mechanisms underlying cancer initiation and clonal evolution and to detect such events early, which is expected to significantly impact clinical management of childhood cancers. Dr. Xiaotu Ma has extensive experience in cancer genomics, intra-tumor heterogeneity and computational method development.

Application Deadline: Open Until Filled

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21. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

We are excited to announce a postdoctoral fellowship available in the laboratory of Dr. Charles Roberts in the Division of Molecular Oncology at St. Jude Children’s Research Hospital in Memphis, TN. Dr. Roberts is a leader in the field of cancer epigenetics, and his research has provided new insights into the central role of chromatin remodeling perturbations in cancer, discoveries that have been translated into investigational therapies for both pediatric and adult cancer patients. His research specifically focuses on SWI/SNF (BAF) chromatin remodeling complexes. Perturbation of these complexes has broad relevance to cancer as at least nine genes that encode SWI/SNF subunits are collectively mutated in over 20% of all cancers, making this the most frequently mutated chromatin regulator in human malignancies.

Application Deadline: Open Until Filled

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22. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

An exciting career opportunity is available for a postdoctoral researcher in the laboratory of Dr. Andrew Davidoff to explore novel gene therapy and small molecule techniques in the treatment of solid tumors. The Davidoff lab seeks an inventive researcher to develop novel gene therapy vectors and test them in our translational models of neuroblastoma and liver cancers. The ideal candidate will have experience with models of solid tumors and/or AAV-based gene therapy vectors, to seek innovative cures for rare pediatric cancers.

Application Deadline: Open Until Filled

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