Cold Spring Harbor Laboratory, New York, USA invites multiple online application for Postdoctoral Positions in various research areas. Candidates interested in Postdoctoral Fellowships can check the details and may apply as soon as possible.
1. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
The Cheadle Lab at Cold Spring Harbor Laboratory is inviting applications from highly motivated candidates for a postdoctoral position investigating interactions between neurons and immune cells (microglia) in the developing brain. We employ a unique multidisciplinary strategy to study these interactions that merges two-photon imaging in the brains of live awake mice, single-cell or low input genomics, and standard molecular and cell biological approaches. We seek an enthusiastic and independent lab member to lead a high-impact project focused on defining the mechanisms underlying microglial function in mouse and human brains. Candidates from non-traditional and/or underrepresented backgrounds, broadly defined, are strongly encouraged to apply.
Application Deadline: Open Until Filled
2. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
The Meyer lab in the Simons Center for Quantitative Biology at Cold Spring Harbor Laboratory is looking for post-doctoral fellows interested in combining computational and experimental approaches to study the genetics of human T cell development. We have two, fully funded positions, with either a focus on experimental immunology or quantitative genetics and data analyses. Experience in both areas would be welcome, but sufficient enthusiasm and excitement to learn can replace lack of experience. Both projects revolve around the genetics of T cell development and immune cell function during childhood and their link to the genetics of immune-mediated diseases. Successful candidates will work as part of a larger interdisciplinary team of computational and experimental scientists and in collaboration with clinical investigators. For more information on our research program, see https://meyer-lab-cshl.github.io/
Application Deadline: Open Until Filled
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3. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
A post-doctoral position in computational biology is available in David McCandlish’s group in the Simons Center for Quantitative Biology at Cold Spring Harbor Laboratory. Research in the McCandlish laboratory is focused on the analysis of high-throughput mutagenesis data, with the goal of accurately predicting the phenotypic, health, and evolutionary consequences of both single and multiple mutations in protein coding and regulatory sequences. The successful candidate will develop new statistical and mathematical techniques for modeling the effects of mutations and will conduct analyses on a variety of data sets. Current research directions involve semi-parametric statistics, Markov chains, Gaussian processes, and population-genetic theory. This position is affiliated with the Simons Center for Quantitative Biology (SCQB).
Application Deadline: Open Until Filled
4. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
The Kinney Lab develops experimental, computational, and mathematical approaches for deciphering the biophysical mechanisms of gene regulation. The primary biological goal of their research is to quantitatively understand the mechanisms of alternative mRNA splicing, as well as the effects of splice-modifying drugs for treating human disease. Their experimental work centers on the use of MPRAs, a technology that Dr. Kinney and his lab have pioneered and continue to advance. They also develop machine learning approaches, including deep learning strategies, for extracting quantitative models of sequence-function relationships from MPRA datasets and for interpreting these models in terms of underlying biophysical mechanisms. Please visit http://kinneylab.cshl.edu/ for more information.
Application Deadline: Open Until Filled
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5. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
Dr. Lingbo Zhang’s Lab at Cold Spring Harbor Laboratory focuses on both basic science and translational medicine of hematologic malignancies. The research of the Lab centers on normal and malignant stem and progenitor cells in the hematopoietic system and decodes the role of metabolites, including micronutrients and neurotransmitters, in the tumor microenvironment and their genetic effectors in regulating hematologic malignancies. There are two fully funded postdoctoral fellowships available to investigate the roles of these critical metabolites and their genetic effectors in hematopoietic malignancies and develop novel therapeutic strategies. The Lab utilizes a combination of CRISPR/Cas functional genomics and metabolomics approaches to systematically uncover the critical metabolites and their genetic effectors, including receptors and metabolic enzymes, to reveal mechanistic insights of and identify key drug targets for hematologic malignancies. The ultimate goal is to understand how environmental signals such as diets and nervous system activities modulate blood cell development and cancers. Based on these basic mechanistic insights, the Lab is building innovative therapeutics to treat hematopoietic malignancies that are currently without effective therapeutic options.
Application Deadline: Open Until Filled
6. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
We are currently seeking innovative, inventive, and self-driven Postdoctoral Associates within the lab of Dr. Leemor Joshua-Tor at Cold Spring Harbor Laboratory. The Joshua-Tor lab studies the structure and mechanism of gene silencing pathways as well as DNA replication. To get a complete understanding of how these processes, the team employs structural, biochemical, biophysical and molecular biology approaches to study how key proteins work at the molecular level. More information can be found on their website. The lab enjoys extremely frequent access to a Titan Krios cryo-electron microscope equipped with a Gatan K3 camera. They also have a screening microscope (Talos 120C), and a chameleon system for grid preparation was just installed in addition to Vitrobot and Leica plungers. There is an excellent fully equipped and soon to be upgraded X-ray facility, crystallization robots and fantastic computational resources including high-performance and GPU computers. Combined with the nearby NSLS-II, these are exciting times with exciting capabilities. The lab is also equipped with state-of-the-art instruments for studying macromolecular interactions, and CSHL has an array of cutting-edge core facilities.
Application Deadline: Open Until Filled
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7. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
Together, the Borniger, Lukey, and Janowitz laboratory at Cold Spring Harbor Laboratory (CSHL) offer a unique opportunity for a highly motivated and creative postdoctoral researcher, with strong experimental and analytical skills, to investigate the reciprocal interaction of sleep and cancer progression. You will become part of a multidisciplinary team of basic researchers and clinicians studying tumor-host interactions, using integrative techniques from neuroscience, endocrinology, metabolomics, and immunology to dissect the mechanisms connecting sleep disruption with aberrant metabolic and immune responses during cancer progression. We are looking for candidates who will develop their own research questions in line with the overarching goals of this program. Substantial resources will be available to the selected candidate, including state-of-the-art laboratory space and the opportunity to discuss science in a diverse and supportive environment. Opportunities to develop skills in the use of murine models of cancer, advanced microscopy, optogenetics/chemogenetics, metabolomics, and biostatistics will be available.
Application Deadline: Open Until Filled
8. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
The Janowitz Laboratory at CSHL is seeking a highly motivated, creative, and interactive postdoctoral researcher with strong experimental and analytical skills to contribute to research on the connectivity of the host response to cancer. We employ pre-clinical and clinical research to develop and test new treatment strategies and to discover fundamental biological interactions between tumors and host organ systems. We are looking for candidates interested in developing their own research question in alignment with the interests and skills present in the laboratory and institution. The selected candidate will be provided significant resources, including access to state-of-the-art laboratory space and the opportunity to discuss science in a relaxed and diverse atmosphere defined by constructive critical appraisal. Opportunities to learn about model systems of disease, advanced microscopy, genetic engineering, new sequencing techniques, bioinformatics, translational science, and statistical analyses will be provided.
Application Deadline: Open Until Filled
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9. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
The Furukawa lab has NIH-funded postdoctoral fellow/associate positions available for scientists interested in solving questions in neurobiology and neuro-cancer-immunology by implementing a dynamic range of techniques including structural biology (cryo-EM, x-ray crystallography, molecular dynamics) together with electrophysiology (patch-clamp, slice physiology, lipid bilayer), protein engineering, chemical biology, mouse model, cellular imaging, and cancer mouse model. We have an excellent track record for unraveling detailed mechanisms and developing reagents for ligand-gated ion channels and will be conducting biological researches based on the gained molecular knowledge. CSHL is equipped with a Titan-KRIOS electron microscope/K3 direct electron detector and a Talos L120C screening microscope. It has an in-house x-ray generator/detector and convenient access to the NSLS-II synchrotron beamlines (AMX and FMX). CSHL has solid core facilities including high-performance computation (CPU/GPU), antibody production, cellular imaging, CRISPR/RNAi, single-cell sequencing, etc. We offer a unique training environment for research and career development.
Application Deadline: Open Until Filled
10. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
The Engel lab in the Department of Neuroscience at Cold Spring Harbor Laboratory invites applications from highly motivated candidates for a postdoctoral position working on the cutting-edge research in computational neuroscience. We are looking for theoretical/computational scientists to work at the exciting interface of systems neuroscience, machine learning, and statistical physics, in close collaboration with experimentalists. The postdoctoral scientist is expected to exhibit resourcefulness and independence, developing computational models of large-scale neural activity recordings with the goal to elucidate neural circuit mechanisms underlying cognitive functions.
Application Deadline: Open Until Filled
11. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
Cold Spring Harbor Laboratory invites applications for a Computational Post Doc in the laboratory of Dr. Alexander Dobin. The successful candidates will join a team of biological data scientists working on novel statistical methods and computational algorithms for multi-omics processing and integration, and leverage Big Genomic Data to elucidate various problems in precision health, such as genetic and epigenetic mechanisms of cancer development and progression, and clinical impact of functional variants. Cold Spring Harbor Laboratory is a world-renowned research and educational institution recognized internationally for its excellence in ground-breaking research programs in cancer, neuroscience, plant biology, genomics, and bioinformatics and broad educational mission.
Application Deadline: Open Until Filled
12. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
The Yeh Laboratory at CSHL Cancer Center (http://yehlab.labsites.cshl.edu) is looking for a postdoctoral fellow to carry out a new drug discovery project harnessing stapled peptide technology and diversity-oriented synthesis. The Yeh Lab is a highly-collaborative environment with state-of-the-art facilities and expertise in biotherapeutics engineering and chemical biology. The Yeh Lab also engages in several close collaborations with other research groups in CSHL. The postdoctoral fellow will enjoy the highly intellectual, cross-disciplinary and collaborative interactions at CSHL.
Application Deadline: Open Until Filled
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13. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
The Levy and Wigler research group at Cold Spring Harbor Laboratory, NY are seeking independent and motivated researchers in Computational Biology, Genetics and Bioinformatics. The successful candidate will have a key role in a multi-disciplinary team of wet-bench and computational researchers working to revolutionize cancer detection and treatment by developing novel genomic technologies. The candidate will work closely with bench scientists drafting the initial computational workflows to analyze new experimental data. Developing a relationship of feedback and understanding between the bench and the computer is essential to work of our group. Rather than building a single pipeline to analyze a set of standardized data, our computational scientists routinely develop custom algorithms that shape protocol development and design. For candidates eager to obtain cross-discipline experience, this position is an opportunity to learn from a group with substantial expertise in both computational and molecular biology.
Application Deadline: Open Until Filled
14. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
A postdoctoral position is available, in the laboratory of Dr. David L. Spector at Cold Spring Harbor Laboratory, for a highly motivated outstanding individual to study long non-coding RNAs (lncRNAs) in breast cancer progression using patient-derived organoids as a model system. LncRNAs are an exciting class of thousands of RNAs among which very few have thus far been functionally characterized. We recently performed an RNA-seq screen in patient-derived breast tumor organoids and identified lncRNAs over-expressed in tumor organoids vs normal. The proposed studies will interrogate the functional role of specific lncRNAs in breast cancer initiation, progression, and metastasis, as well a their potential as therapeutic targets. Experience in breast cancer, molecular biology, extensive genomic analysis, organoids, and mouse models is a plus.
Application Deadline: Open Until Filled
15. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
A postdoctoral position in COMPUTATIONAL GENOMICS is available in Dr. Adam Siepel’s research group at the Simons Center for Quantitative Biology (SCQB), Cold Spring Harbor Laboratory. The Siepel Group specializes in the development of probabilistic models and algorithms for inference, machine-learning methods, and applications in large-scale genomic data analysis. Of particular interest is research relevant to existing NIH-supported projects in: 1. EVOLUTIONARY GENOMICS of humans and other mammals, including inference of ancestral recombination graphs, detection of selective sweeps, comparative genomics of bats, inference of distributions of fitness effects and quantification of genetic load from linked deleterious alleles; and 2. TRANSCRIPTIONAL REGULATION in mammals, including quantification of initiation and pause-release rates from nascent RNA sequencing data, characterization of elongation rates, and evolutionary analysis of transcriptional regulation across primates and other mammals.
Application Deadline: Open Until Filled
16. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
A post-doctoral position is available at the Schorn lab, Cold Spring Harbor Laboratory, NY. We are interested in how small RNAs identify and silence transposable elements when they become active during mammalian development and disease. We found that tRNA fragments (tRF) derived from the 3’-end of mature tRNAs are highly expressed in cells undergoing epigenetic reprogramming and target LTR-retroelements, or endogenous retroviruses (ERVs), at their conserved tRNA primer binding site (PBS). Due to the perfect sequence complementarity of 3’-tRFs to the PBS, they have tens of thousands of targets in mammalian genomes. 3’-tRFs are processed under yet unknown conditions and potentially protect many eukaryotes. This is an exciting new field with many opportunities! We believe tRFs are an ancient link between RNAi, transposons and genome stability. We are determining the intersection of tRFs with other small RNA silencing pathways and their effect on pluripotency and differentiation. Our main tools are cell culture transposition assays, long & small RNA sequencing, chromatin IPs, NGS analysis of repetitive sequences, CRISPR, etc.
Application Deadline: Open Until Filled
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17. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
A postdoctoral fellow position is available in the laboratory of Dr. Linda Van Aelst, Professor at Cold Spring Harbor Laboratory. The main focus of research will be to study the roles of genes associated with human diseases in the development and function of neural circuits, using molecular, genetic and viral engineering, optogenetics, imaging, electrophysiology, and behavior analysis.
Application Deadline: Open Until Filled
18. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
Two postdoctoral positions in biological computation / “algorithms in nature” are available in Dr. Saket Navlakha’s research group at the Simon’s Center for Quantitative Biology at Cold Spring Harbor Laboratory, NY. We are looking for post-docs broadly interested in studying biological information processing from an algorithmic perspective. The goal is to discover new ideas for computation by studying problem-solving strategies used in nature, and to ground these ideas by fostering deep collaborations with experimental biologists. Most recently, we have been interested in neural circuit computation and plant architecture optimization, but new areas are also welcome.
Application Deadline: Open Until Filled
19. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
The Meyer and Navlakha labs in the Simons Center for Quantitative Biology at Cold Spring Harbor Laboratory are looking for a post-doctoral fellow interested in combining computational and experimental approaches to study tolerance induction and generation of diversity in the immune system. Computationally, the position will require experience in machine learning and statistics. Experimentally, the position will require experience in in vitro imaging combined with cell tracking experiments and tissue culture. An ideal candidate would be well-versed in both, but sufficient enthusiasm and excitement to learn can replace lack of experience. Cold Spring Harbor Laboratory is a world-renowned research and education institution recognized internationally for its excellence in fundamental areas, such as cancer, neuroscience, plant biology, genomics, and quantitative biology. The Laboratory has long been recognized as a place for nurturing young scientists, with post-doctoral researchers being an integral part of the discovery process. The Laboratory offers a warm, collegial, and collaborative work environment in a beautiful location about one hour from New York City.
Application Deadline: Open Until Filled
