University of Pennsylvania, Pennsylvania, USA invites multiple online application for Postdoctoral Fellowships (Salary: $54,835 – $66,600) in various research areas. Candidates interested in Postdoctoral Fellowships can check the details and may apply as soon as possible.
1. Two Postdoctoral Position in cancer and neurodegeneration
Summary of Postdoctoral Fellowship:
Two postdoctoral researcher positions are available in the laboratory of Dr. Xiaolu Yang at the Perelman School of Medicine at the University of Pennsylvania. The Yang lab is interested in molecular and cellular mechanisms that protect against cancer and neurodegeneration. The current projects focus on two broad areas: The tumor suppressor p53, metabolism, and autophagy. We are interested in the regulation and functions of the preeminent tumor suppressor p53. Our results have revealed an important role for p53 in modulating metabolic pathways that are critical for biosynthesis and redox balance. We are investigating the function of p53 as both a sentinel and a regulator for metabolic activities.
Application Deadline: Open Until Filled
2. Postdoctoral Position in Cardiovascular Research
Summary of Postdoctoral Fellowship:
A postdoctoral fellow position is available in the Cardiovascular Institute of the University of Pennsylvania Perelman School of Medicine to perform basic-translational research focused on the coronary microvasculature. Coronary Microvascular Disease (CMVD) accounts for 30-50% of ischemic heart disease yet has been understudied in the past. We have developed novel methods to image the coronary microcirculation and uncover novel mechanisms of CMVD. This position focuses on using genomics, mouse models, novel mouse imaging, and cell and molecular studies on gene regulation to understand the pathogenesis of CMVD and develop novel therapeutic approaches.
Application Deadline: Open Until Filled
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3. Postdoctoral Position in metastatic microenvironment
Summary of Postdoctoral Fellowship:
A POSTDOCTORAL POSITION to continue and expand studies into the mechanisms of immuno-suppression in the primary tumor and metastatic microenvironment and importance of these mechanisms in cancer therapies (as described in Cancer Cell 2017 and 2019, Cell Metab 2022, Nat Cancer 2020 and 2022 and J Clin Invest 2021). Qualifications: Highly motivated applicants with a doctoral degree (PhD or MD/analogue) and strong interests in the areas of tumorigenesis, immunity and inflammation and experience in molecular/cell biology and/or pathology and genetics of mouse disease models are encouraged to apply.
Application Deadline: Open Until Filled
4. 2+ Postdoctoral Position in imaging and genomics
Summary of Postdoctoral Fellowship:
Multiple NIH-funded postdoctoral positions are available in the laboratory of Rajan Jain in the Departments of Medicine and Cell & Developmental Biology at the Perelman School of Medicine at the University of Pennsylvania. Our laboratory uses genetic, biochemical, imaging and genomic approaches to decipher how nuclear architecture governs cell fate decisions. Our laboratory routinely utilizes multiple mouse models and ESC/iPSC differentiation strategies. We are part of a vibrant community at Penn, including the Epigenetics Institute, Institute for Regenerative Medicine, Cardiovascular Institute and Center for Engineering and Mechanobiology. We are a highly collaborative group that routinely works across disciplines.
Application Deadline: Open Until Filled
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5. Postdoctoral Position in Human Genome Editing
Summary of Postdoctoral Fellowship:
A postdoctoral position for a computational biologist is available in the interdisciplinary Human Genome Editing and Translational and Correlative Sciences Laboratories. We are part of the Department of Microbiology within the University of Pennsylvania Perelman School of Medicine. We are also a member of the Center for Cellular Immunotherapies and Abramson Cancer Center. Our group is multidisciplinary, integrating computational and experimental approaches to develop a single to collective cell understanding of gene regulation in engineered immune cells and their interaction with tumor cells.
Application Deadline: Open Until Filled
6. Postdoctoral Position in human tumor immunology
Summary of Postdoctoral Fellowship:
We are seeking a highly devoted and enthusiastic PhD or MD/PhD scientist to join our group as a postdoctoral research fellow. He/She will be involved in investigating the role of the inflammatory myeloid cells in the tumor microenvironment and the cellular and molecular mechanisms by which tumor modulates their immune functions in cancer patients. Specifically, the researcher will investigate the role of the tumor-infiltrating macrophages and neutrophils in the regulation of tumor-specific T cell and NK cell responses in lung cancer patients. Also, He/She will investigate the ability of tumor-associated neutrophils and macrophages to regulate anti-tumor antibody-triggered immune responses.
Application Deadline: Open Until Filled
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7. Postdoctoral Position in Duchenne’s Muscular Dystrophy Therapy
Summary of Postdoctoral Fellowship:
A position is available in the Khurana laboratory at The Department of Physiology & Pennsylvania Muscle Institute to conduct basic and translational research on muscular dystrophy; specifically to develop Utrophin Gene Editing for Duchenne’s Muscular Dystrophy Therapy. We use a combination of physiological, molecular, biochemical and genetic approaches to understand the basic biology of muscle, and develop therapies for the muscular dystrophies.
Application Deadline: Open Until Filled
8. Postdoctoral Position in Neuroepigenetics
Summary of Postdoctoral Fellowship:
The Heller Lab studies the mechanisms by which epigenetic remodeling regulates gene function, in the context of neuropsychiatric diseases such as addiction and depression. To approach this problem, we directly manipulate histone and DNA modifications at specific genes in vivo, using viral delivery of novel epigenetic editing tools, such as CRISPR/dCas9-fusion proteins. This ‘bottom-up’ approach allows direct elucidation of the causal relevance of epigenetic remodeling in the brain. Because addiction and depression persist long after cessation of the harmful experience, epigenetic remodeling is an attractive underlying mechanism and presents an intriguing target for therapeutic intervention.
Application Deadline: Open Until Filled
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9. Postdoctoral Position in Duchenne Muscular Dystrophy
Summary of Postdoctoral Fellowship:
A muscle and cardiovascular biology postdoctoral fellowship position is immediately available in the laboratory of Hansell Stedman, MD, FACS, Department of Surgery, Penn Cardiovascular Institute and Pennsylvania Muscle Institute. The main goals are to improve the understanding of transcriptional control in muscle and to use the novel insights in the development of safe and effective gene therapy for dystrophin-deficient cardiomyopathy and respiratory failure, with the ultimate goal of clinical translation for Duchenne Muscular Dystrophy. We are using complementary approaches to the rational design of next generation vectors to address the shortcomings of candidate therapies tested in recent clinical trials.
Application Deadline: Open Until Filled
10. Postdoctoral Position in Neonatal Resuscitation
Summary of Postdoctoral Fellowship:
The Neonatal Resuscitation Research Program is accepting postdoctoral applications for positions starting July 1, 2023. This position at the Children’s Hospital of Philadelphia (CHOP) will focus on defining translational physiology at birth and associated clinical outcomes for newborns with congenital anomalies. Applicants may include clinical investigators with training in pediatrics or neonatology or early-stage postdoctoral fellows interested in reproductive, perinatal, and pediatric epidemiology.
Application Deadline: Open Until Filled
11. Postdoctoral Position in DNA replication regulation in hematopoietic stem cells
Summary of Postdoctoral Fellowship:
A postdoctoral fellow position is available at the University of Pennsylvania School of Medicine and the Children’s Hospital of Philadelphia, to perform state-of-the-art CRISPR/Cas9 screens to identify novel therapeutic targets for treating hematopoietic stem cell diseases. Hematopoietic stem cells give rise to all circulating blood cells throughout life. Maintenance of stem cell self-renewal, proliferation and differentiation is regulated by complex signaling pathways. Aberrant regulation leads to bone marrow failure or leukemia. Genome integrity plays a critical role in the prevention of leukemia, ageing, and blood development.
Application Deadline: Open Until Filled
12. Postdoctoral Position in in neuroethics
Summary of Postdoctoral Fellowship:
The Wexler Lab at the Department of Medical Ethics & Health Policy at the Perelman School of Medicine at the University of Pennsylvania is seeking a full-time postdoctoral fellow in neuroethics. This is a 12-month position with a desired start date of summer 2023, though earlier/later starts may be considered. There is a possibility for renewal contingent upon funding. The fellow will work on a project that utilizes sociological methods to study the ethical, legal, and social implications of neurotechnology.
Application Deadline: Open Until Filled
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13. Postdoctoral Position in epigenetic mechanisms of neural developmental and disorders
Summary of Postdoctoral Fellowship:
The Akizu lab seeks candidates for a postdoctoral position in epigenetic mechanisms of neural developmental and disorders. The applicant must have a recent PhD in relevant fields, research experience in epigenomic (i.e. ChIPseq, Cut&Run, ATACseq, Hi-C…) OR human pluripotent stem cell culturing and organoid differentiation methods and at least one first author publication in an impactful scientific journal.
Application Deadline: Open Until Filled
14. Two Postdoctoral Position in Genetic Regulation of Skeletal Cells
Summary of Postdoctoral Fellowship:
Two postdoctoral fellow positions are available in the Lefebvre laboratory in the Translational Research Program in Pediatric Orthopaedics at the Children’s Hospital of Philadelphia (CHOP) Abramson Research Institute. The fellows will elucidate specific genetic and epigenetic mechanisms whereby SOX and other transcription factors interact with one another and with growth factor signaling pathways to govern the commitment of mesenchymal progenitor/stem cells to skeletal lineages and the multi-step programs of osteoblast and chondrocyte differentiation.
Application Deadline: Open Until Filled
15. Postdoctoral Position in Bacterial Pathogenesis
Summary of Postdoctoral Fellowship:
A postdoctoral position is available immediately in the Zhu laboratory in the Microbiology Department of the School of Medicine. We are studying pathogen-host-microbiome and antibiotic resistance mechanisms, including Vibrio cholerae and multi-drug resistant enterobacteria.
Application Deadline: Open Until Filled
16. Postdoctoral Position in human immunology and bioinformatics
Summary of Postdoctoral Fellowship:
A postdoctoral position in human immunology and/or bioinformatics is available immediately in the laboratory of Dr. Michael R. Betts at the University of Pennsylvania Perelman School of Medicine. Our group studies human immunology in the context of various human diseases including HIV, SIV, type I diabetes, and others. With our unique access to human samples, we are using high-parameter flow cytometry and next-generation techniques at single-cell resolution to parse through cellular heterogeneity and understand the roles of various rare cell populations in their contribution to human disease.
Application Deadline: Open Until Filled
