1. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Fischer lab at St. Jude is recruiting a Postdoc for an NIH-funded project that exploits the role of water networks in protein binding sites. We are looking for applicants with a strong training in the gene-to-structure pipeline and/or in structural bioinformatics, and a keen interest or ideally experience in ligand discovery.

Application Deadline: Open Until Filled

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2. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The laboratory of Dr. Peijun Ma in the Department of Pharmacy and Pharmaceutical Sciences in St. Jude Children’s Research Hospital, Memphis, TN is a new research group that uses single-cell genomics and transcriptomics to study antibiotic resistance and persistence in bacterial pathogens. Past work has focused on developing bacterial single-cell RNA sequencing technology (Ma et al., Cell, 2023) and understanding the evolution of antibiotic resistance in gram-negative bacterial pathogens (Ma et al., eLife, 2021).

Application Deadline: Open Until Filled

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3. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

A postdoctoral position is available in the Chang lab in the Department of Cell & Molecular Biology at St. Jude Children’s Research Hospital. We are looking for highly talented, self-motivated individuals passionate about how organelles communicate. In particular, the candidate will interrogate the fundamental questions of ER-to-Golgi trafficking via cutting-edge light and electron microscopy, genome-editing, biochemistry and in vitro reconstitution approaches.

Application Deadline: Open Until Filled

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4. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

We are seeking a highly motivated Postdoc Research Associate to join Dr. Ji Sun’s lab at St. Jude Children’s Research Hospital. Successful candidates will lead research projects focusing on disease-causing protein complexes, using an integrative approach combining structural, biochemical, and cell biology methods (Myasnikov A et al., Cell 2021; Zhu H et al., Biorxiv 2022, Jiang M et al., Cell Research, 2023).

Application Deadline: Open Until Filled

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5. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

A postdoctoral research associate position is immediately available in the laboratory of Dr. Xiang Chen in the department of Computational Biology to develop and apply innovative machine learning/statistical learning approaches to understand interactions between genetic alterations and epigenetic deregulations and to discover potential biomarkers for predicting drug responses in pediatric cancers. One of the premier pediatric research institutions in the world, St. Jude Children’s Research Hospital provides exceptional resources, a collaborative environment, and access to extensive, unique cancer genomics datasets from large-scale research initiatives.

Application Deadline: Open Until Filled

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6. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Several postdoctoral researcher positions are immediately available in the laboratory of Dr. Doug Green in the Department of Immunology in St. Jude Children’s Research Hospital. Research in Dr. Green’s laboratory focuses on the process of active cell death and cell survival, extending from the role of cell death in cancer regulation and immune responses in the whole organism to the fundamental molecular events directing the death and survival of the cell. Preference will be given to individuals with an interest in cell death mechanisms, or the metabolism of activated T lymphocytes.

Application Deadline: Open Until Filled

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7. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

A postdoctoral position is available at St. Jude Children’s Research Hospital for an outstanding and highly motivated candidate to investigate the proteins of the innate immune system biochemically and structurally. We are particularly interested in assessing proteins involved in innate immune responses and cell death (NLRs, caspases, inflammasomes, and inflammatory cell death, PANoptosis).

Application Deadline: Open Until Filled

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8. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Obeng Laboratory is seeking creative and highly motivated candidates for a fully supported postdoctoral fellowship studying the pathogenesis of myeloid malignancies. The major interests of the lab are determining how acquired mutations in hematopoietic stem cells lead to the development of clonal hematopoiesis, myelodysplastic syndrome, and leukemia, in addition to identifying and studying novel treatments that selectively target malignant clones.

Application Deadline: Open Until Filled

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9. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Postdoctoral positions are available in the laboratory of Dr. Stacey Ogden at St. Jude Children’s Research Hospital to research mechanisms of Sonic Hedgehog signaling during development. We use genetic model systems and cutting-edge imaging technologies to interrogate these fascinating cell biological questions. Prior experience with mouse models and confocal microscopy is preferred, but not required.

Application Deadline: Open Until Filled

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10. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Postdoctoral positions are available in the laboratory of Dr. Stacey Ogden at St. Jude Children’s Research Hospital to research mechanisms of Sonic Hedgehog signaling during development. We use genetic model systems and cutting-edge imaging technologies to interrogate these fascinating cell biological questions. Prior experience with mouse models and confocal microscopy is preferred, but not required.

Application Deadline: Open Until Filled

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11. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Obeng Laboratory is seeking creative and highly motivated candidates for a fully supported postdoctoral fellowship studying the pathogenesis of myeloid malignancies. The major interests of the lab are determining how acquired mutations in hematopoietic stem cells lead to the development of clonal hematopoiesis, myelodysplastic syndrome, and leukemia, in addition to identifying and studying novel treatments that selectively target malignant clones.

Application Deadline: Open Until Filled

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12. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

HSCs represent the most therapeutically exploited adult stem cell compartment, used routinely to treat leukemia and hematologic disease via HSC transplantation. Indeed, HSC transplantation represents the only cure for Sickle Cell Disease, including autologous HSC transplantation combined with gene therapy. Here, our major goals are to better understand how elevated hematopoietic demand and chronic inflammation associated with Sickle Cell Disease perturbs the phenotype and function of HSCs. We employ both genetic mammalian model systems and primary patient samples to pursue these aims.

Application Deadline: Open Until Filled

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13. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Tsai Laboratory is seeking dynamic and creative candidates for a fully supported postdoctoral fellowship on genome editing technologies for therapeutic treatment of genetic disorders. CRISPR genome editors, adapted from bacterial adaptive immune systems, are transforming both basic biological research and genomic medicine. At St. Jude, we are working toward advancing these technologies towards patient treatments for sickle cell disease and bone marrow failure disorders.

Application Deadline: Open Until Filled

More Details

14. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

An exciting career opportunity is available for a postdoctoral researcher in the laboratory of Dr. Andrew Davidoff to explore novel gene therapy and small molecule techniques in the treatment of solid tumors. The Davidoff lab seeks an inventive researcher to develop novel gene therapy vectors and test them in our translational models of neuroblastoma and liver cancers. The ideal candidate will have experience with models of solid tumors and/or AAV-based gene therapy vectors, to seek innovative cures for rare pediatric cancers.

Application Deadline: Open Until Filled

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15. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

A wet-lab postdoctoral position is available immediately in the Northcott Lab (Department of Developmental Neurobiology) to join a highly collaborative team studying the developmental and molecular basis of the childhood brain tumor medulloblastoma. The Northcott Lab has established an internationally renowned track record in pediatric neuro-oncology, substantiated by numerous impactful publications in Nature, Cancer Cell, Lancet Oncology, and Journal of Clinical Oncology. Leveraging our exquisite access to patient material linked to large clinical trial cohorts, we are applying a combination of innovative, multi-omic approaches to discover new biological, mechanistic, and clinical insights responsible for medulloblastoma initiation, progression, and relapse.

Application Deadline: Open Until Filled

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16. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Chen Lab studies: i) Chemical modulation of transcription; ii) Signal crosstalk among transcription factors; and iii) Selective inhibition of highly homologous enzymes. We take a hypothesis-driven and technology-enabled multidisciplinary approach to develop chemical probes and investigate biological mechanisms. Particularly we use the promiscuous xenobiotic nuclear receptors (PXR and CAR) as models to investigate the transcription networks that regulate therapeutic responses. PXR and CAR regulate the detoxification system (e.g., by transcriptionally controlling CYP3A4 and CYP3A5—drug-metabolizing enzymes that metabolize more than 50% of clinical drugs), the dysregulation of which contributes to drug toxicity and drug resistance.

Application Deadline: Open Until Filled

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17. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Several postdoctoral positions are available in the laboratory of Dr. Victor J. Torres in the new Department of Host-Microbe Interactions at St. Jude Children’s Research Hospital. The Torres lab is interested in dissecting the complex interactions between pathogenic bacteria and the mammalian host. Currently, the lab is focusing on antibiotic resistant (AMR) bacteria, which have been recognized by the World Health Organization as a serious threat to human health.

We take advantage of multidisciplinary approaches and combine techniques from bacteriology, genetics, molecular biology, biochemistry, structural biology, cellular biology, and immunology with primary tissue culture models and a variety of murine models of infection, to address our favorite questions. Our ultimate goal is to understand the basic principles of bacterial pathogenesis as well as to develop a platform for the discovery of targets that could be exploited for the generation of much-needed therapies.

Application Deadline: Open Until Filled

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18. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Advance hope, medical science, statistical science, and your career as a postdoctoral fellow in the Department of Biostatistics at St. Jude Children’s Research Hospital. A Ph.D. in statistics, biostatistics, computer science, or closely related field is required. Appointment is for two years. Applicants must have a strong computational background and demonstrate excellent written and verbal communication skills.

Application Deadline: Open Until Filled

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19. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Gottschalk Laboratory is seeking a highly motivated and creative candidate for a fully supported postdoctoral fellowship to develop immune-based therapies. Specifically, the research is aimed to develop T-cell-based therapies for pediatric solid tumors. Studies are focused on using genetic engineering approaches to not only render immune cells cancer specific, but also improve their effector function.

Genetically modified immune cells will be studied in preclinical models with special emphasis on how adoptively transferred cells interact with tumor cells, the tumor microenvironment, and resident immune cells. Ultimate goal of these studies is to translate these approaches into early Phase clinical testing.

Application Deadline: Open Until Filled

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20. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Advance hope, medical science, statistical science, and your career as a postdoctoral fellow in the Department of Biostatistics at St. Jude Children’s Research Hospital. For eight consecutive years, St. Jude has ranked among the top places to work in the U.S. by Forbes Magazine. Salary and benefits are competitive. Send cover letter, CV, and three recommendation letters to Dr. Tomi Mori via e-mail at tomi.mori@stjude.org.

Application Deadline: Open Until Filled

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21. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The project aims to understand how KDMs coopts oncogenic transcription factors to drive tumorigenesis and metastasis, and use novel KDM inhibitors to target metastasis and disease relapse. To this end, we apply interdisciplinary strategies by integrating genetic approaches (transgenic mouse models and conditional knockout) with cutting-edge systems (Cut&Tag, HiChIP, ATAC-seq, scRNA-seq, spatial transcriptomics), and functional genomics tools (Genome-wide and focused CRISPR libraries, CRISPR knockin, CRIPSRi and CRISPRa) as well as proteomics and metabolomics.

Application Deadline: Open Until Filled

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The post 21 Postdoctoral Fellowships at St. Jude Children’s Research Hospital, Tennessee appeared first on FellowshipBard.

1. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The project aims to understand how KDMs coopts oncogenic transcription factors to drive tumorigenesis and metastasis, and use novel KDM inhibitors to target metastasis and disease relapse. To this end, we apply interdisciplinary strategies by integrating genetic approaches (transgenic mouse models and conditional knockout) with cutting-edge systems (Cut&Tag, HiChIP, ATAC-seq, scRNA-seq, spatial transcriptomics), and functional genomics tools (Genome-wide and focused CRISPR libraries, CRISPR knockin, CRIPSRi and CRISPRa) as well as proteomics and metabolomics.

Application Deadline: Open Until Filled

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2. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

You will be part of an interdisciplinary team that uses modern structural biology (variable temperature crystallography) to characterize disease-relevant protein states, computational methods (MD, docking, custom software) to analyze and exploit them, and experiments (biophysical, biochemical, cell-based assays) to test the impact of small molecules on biology and disease.

Application Deadline: Open Until Filled

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3. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

A postdoctoral position is available in the Chang lab in the Department of Cell & Molecular Biology at St. Jude Children’s Research Hospital. We are looking for highly talented, self-motivated individuals passionate about how organelles communicate. In particular, the candidate will interrogate the fundamental questions of ER-to-Golgi trafficking via cutting-edge light and electron microscopy, genome-editing, biochemistry and in vitro reconstitution approaches. Prerequisites are creativity, dedication, and the ability to work collaboratively in a small group.

Application Deadline: Open Until Filled

More Details

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4. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The laboratory of Dr. Peijun Ma in the Department of Pharmacy and Pharmaceutical Sciences in St. Jude Children’s Research Hospital, Memphis, TN is a new research group that uses single-cell genomics and transcriptomics to study antibiotic resistance and persistence in bacterial pathogens. Past work has focused on developing bacterial single-cell RNA sequencing technology (Ma et al., Cell, 2023;) and understanding the evolution of antibiotic resistance in gram-negative bacterial pathogens (Ma et al., eLife, 2021;).

Application Deadline: Open Until Filled

More Details

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5. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Chen Lab is recognized for developing innovative machine learning and statical learning approaches and has led intratumoral heterogeneity and epigenetic deregaultions in pediatric cancers, spearheaded publications in Nature, Genome Biology, Nucleic Acid Research, Neuron, Cancer Cells, Developmental Cells, Science immunology and Nature Communications in the last five years and is funded by the NCI. St. Jude offers a highly interactive and supportive environment for researchers’ career development, including state-of-the-art high-performance computing facilities, robust analytical pipelines, the latest wet-lab technology, access to outstanding core facilities and scientific expertise in genomics, cancer biology, statistics, and computer science.

Application Deadline: Open Until Filled

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6. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Several postdoctoral positions are available in the laboratory of Dr. Victor J. Torres in the new Department of Host-Microbe Interactions at St. Jude Children’s Research Hospital. The Torres lab is interested in dissecting the complex interactions between pathogenic bacteria and the mammalian host. Currently, the lab is focusing on antibiotic resistant (AMR) bacteria, which have been recognized by the World Health Organization as a serious threat to human health. We take advantage of multidisciplinary approaches and combine techniques from bacteriology, genetics, molecular biology, biochemistry, structural biology, cellular biology, and immunology with primary tissue culture models and a variety of murine models of infection, to address our favorite questions.

Application Deadline: Open Until Filled

More Details

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7. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Yu Lab within the Department of Computational Biology is currently seeking exceptional candidates for a Postdoctoral Research Associate position with a focus on single-cell & spatial omics and systems immunology. The Yu Lab is dedicated to developing advanced systems biology algorithms, such as NetBID (Du, Nature 2018), NetBID2 (Dong, Nat Common, 2023), and scMINER (Ding, in revision). These algorithms integrate multi-omics data at both bulk and single-cell levels to dissect intracellular and intercellular network dynamics in healthy and diseased states, identify underlying hidden drivers, and ultimately translate these discoveries into potential clinical applications.

Application Deadline: Open Until Filled

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8. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

We are seeking a highly motivated Postdoc Research Associate to join Dr. Ji Sun’s lab at St. Jude Children’s Research Hospital. Successful candidates will lead research projects focusing on disease-causing protein complexes, using an integrative approach combining structural, biochemical, and cell biology methods (Myasnikov A et al., Cell 2021; Zhu H et al., Biorxiv 2022, Jiang M et al., Cell Research, 2023). The lab has full access to the state-of-the-art cryo-EM facility in St. Jude, which houses a 300kV Titan Krios and a 200 kV Talos Arctica electron microscope equipped with K3 detectors.

Application Deadline: Open Until Filled

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9. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Chen Lab studies: i) Chemical modulation of transcription; ii) Signal crosstalk among transcription factors; and iii) Selective inhibition of highly homologous enzymes. We take a hypothesis-driven and technology-enabled multidisciplinary approach to develop chemical probes and investigate biological mechanisms. Particularly we use the promiscuous xenobiotic nuclear receptors (PXR and CAR) as models to investigate the transcription networks that regulate therapeutic responses. PXR and CAR regulate the detoxification system (e.g., by transcriptionally controlling CYP3A4 and CYP3A5—drug-metabolizing enzymes that metabolize more than 50% of clinical drugs), the dysregulation of which contributes to drug toxicity and drug resistance.

Application Deadline: Open Until Filled

More Details

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10. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

A wet-lab postdoctoral position is available immediately in the Northcott Lab (Department of Developmental Neurobiology) to join a highly collaborative team studying the developmental and molecular basis of the childhood brain tumor medulloblastoma. The Northcott Lab has established an internationally renowned track record in pediatric neuro-oncology, substantiated by numerous impactful publications in Nature, Cancer Cell, Lancet Oncology, and Journal of Clinical Oncology. Leveraging our exquisite access to patient material linked to large clinical trial cohorts, we are applying a combination of innovative, multi-omic approaches to discover new biological, mechanistic, and clinical insights responsible for medulloblastoma initiation, progression, and relapse.

Application Deadline: Open Until Filled

More Details

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11. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Vevea Lab seeks to understand the cell biology of the axon. More specifically, we want to understand how the synaptic vesicle cycle is established and maintained throughout the age of the organism. This focus leads us to ask questions about cellular processes related to organelle polarity and trafficking in the axon, organelle and protein quality control in the neuron, and to examine the fundamental function of proteins that influence the synaptic vesicle cycle but still have unclear or disputed functions.

Application Deadline: Open Until Filled

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12. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

An exciting career opportunity is available for a postdoctoral researcher in the laboratory of Dr. Andrew Davidoff to explore novel gene therapy and small molecule techniques in the treatment of solid tumors. The Davidoff lab seeks an inventive researcher to develop novel gene therapy vectors and test them in our translational models of neuroblastoma and liver cancers. The ideal candidate will have experience with models of solid tumors and/or AAV-based gene therapy vectors, to seek innovative cures for rare pediatric cancers.

Application Deadline: Open Until Filled

More Details

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13. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Tsai Laboratory is seeking dynamic and creative candidates for a fully supported postdoctoral fellowship on genome editing technologies for therapeutic treatment of genetic disorders. CRISPR genome editors, adapted from bacterial adaptive immune systems, are transforming both basic biological research and genomic medicine. At St. Jude, we are working toward advancing these technologies towards patient treatments for sickle cell disease and bone marrow failure disorders.

Application Deadline: Open Until Filled

More Details

14. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

HSCs represent the most therapeutically exploited adult stem cell compartment, used routinely to treat leukemia and hematologic disease via HSC transplantation. Indeed, HSC transplantation represents the only cure for Sickle Cell Disease, including autologous HSC transplantation combined with gene therapy. Here, our major goals are to better understand how elevated hematopoietic demand and chronic inflammation associated with Sickle Cell Disease perturbs the phenotype and function of HSCs. We employ both genetic mammalian model systems and primary patient samples to pursue these aims.

Application Deadline: Open Until Filled

More Details

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15. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The fundamental goal of our research is to understand how neural circuits control movement. We approach this from multiple perspectives, using cutting-edge technologies to analyze the molecular diversity of spinal interneurons, explore how descending systems in the brain convey information to the spinal motor system, and define the functional roles of spinal interneurons in generating behavior.

Application Deadline: Open Until Filled

More Details

16. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Postdoctoral positions are immediately available in the laboratory of Dr. Mark Leggas in the Department of Pharmacy and Pharmaceutical Sciences to study the pharmacology and effects of treatment in infants with neonatal abstinence syndrome. We are looking for highly motivated candidates with experience in one or more of the following areas: a) pharmacogenetics or epigenetics, b) microbiome, and c) bioinformatics of lipidomic and/or metabolomic workflows.

Application Deadline: Open Until Filled

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17. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Advance hope, medical science, statistical science, and your career as a postdoctoral fellow in the Department of Biostatistics at St. Jude Children’s Research Hospital. As a fellow you will join our faculty in the Department of Biostatistics in providing statistical support and developing innovative statistical methods for research projects at the cutting edge of biomedical research. A position is available in statistical research to develop and improve individualized treatment rules using machine learning methods on electronic health records data and clinical trial studies.

Application Deadline: Open Until Filled

More Details

18. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Gottschalk Laboratory is seeking a highly motivated and creative candidate for a fully supported postdoctoral fellowship to develop immune-based therapies. Specifically, the research is aimed to develop T-cell-based therapies for pediatric solid tumors. Studies are focused on using genetic engineering approaches to not only render immune cells cancer specific, but also improve their effector function. Genetically modified immune cells will be studied in preclinical models with special emphasis on how adoptively transferred cells interact with tumor cells, the tumor microenvironment, and resident immune cells. Ultimate goal of these studies is to translate these approaches into early Phase clinical testing.

Application Deadline: Open Until Filled

More Details

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19. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Abraham lab studies gene expression-regulation mechanisms in healthy and diseased mammalian cells. We are recruiting computational biologists to collaboratively develop computational tools and frameworks to analyze high-throughput sequencing (-omics) data. We build analytical software pipelines to find answers to biological questions about gene regulation in big datasets, usually from applied sequencing experiments like ChIP-Seq, RNA-Seq, and Hi-ChIP. Our interests center on enhancers and super-enhancers. Specifically, we seek to understand how these regulatory elements establish gene expression programs in healthy cells, and how enhancers are altered by mutation, abused by mistargeting, and targetable with drugs in diseased cells.

Application Deadline: Open Until Filled

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The post 19 Postdoctoral Fellowships at St. Jude Children’s Research Hospital, Tennessee appeared first on FellowshipBard.

1. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Nichols Lab at St. Jude Children’s Research Hospital is seeking a highly motivated Postdoctoral Fellow with interests and research experience in hematopoiesis, stem cell biology or leukemia modeling to carry out projects in cancer predisposition. We are interested in identifying novel genes and genetic variants that contribute to development of cancer and primary immunodeficiency. In 2015, we and others identified germline variants in ETV6, the gene encoding the essential hematopoietic transcription factor ETV6, in families affected by autosomal dominant thrombocytopenia and predisposition to B-acute lymphoblastic leukemia (B-ALL). We are now using human and mouse models to decipher how these germline ETV6 variants impact hematopoiesis and promote leukemogenesis.

Application Deadline: Open Until Filled

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2. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Postdoctoral positions are immediately available in the laboratory of Dr. Mark Leggas in the Department of Pharmacy and Pharmaceutical Sciences to study the pharmacology and effects of treatment in infants with neonatal abstinence syndrome or neonatal opioid-withdrawal syndrome. We are looking for highly motivated candidates with pharmacology backgrounds. Experience in one or more areas is desirable: a) pharmacogenetics or epigenetics, b) microbiome, and c) bioinformatics. Although projects are loosely defined within the scope of the NIH R01 award, there are opportunities for new mutually agreed upon directions.

Application Deadline: Open Until Filled

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3. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Postdoctoral positions in metabolomics or lipidomics are immediately available in the laboratory of Dr. Mark Leggas in the Department of Pharmacy and Pharmaceutical Sciences to study the pharmacology and effects of drug treatment in infants with neonatal abstinence syndrome or neonatal opioid-withdrawal syndrome. We seek highly motivated candidates with bioanalytical metabolomics and/or lipidomics experience. Bioinformatic workflow experience is also highly desirable. Although projects are loosely defined within the scope of the NIH R01 award, there are opportunities for new mutually agreed upon directions.

Application Deadline: Open Until Filled

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4. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Immunology postdoctoral positions are available in the laboratory of Dr. Bo Hu in the Department of Immunology, St. Jude Children’s Research Hospital. The Hu lab investigates immunobiology, immunometabolism, and neuroimmunology, by focusing on the interaction of the immune system and the nervous system and its implications for health and diseases. As the immune system and nervous system are tightly connected to regulate host physiology and pathology, understanding these connections allows us to gain new insights into biological concepts and disease targets. The Hu laboratory will combine advanced cellular and molecular techniques in immunology and neurobiology with genetic-engineering tools, quantitative proteomics, and multiplex imaging systems to interrogate neuro-immune interaction in pathophysiological conditions. Please see the following articles published for additional information: Nature 578 (2020); Science 354 (6313) (2016).

Application Deadline: Open Until Filled

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5. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The fundamental goal of our research is to understand how neural circuits control movement. We approach this from multiple perspectives, using cutting-edge technologies to analyze the molecular diversity of spinal interneurons, explore how descending systems in the brain convey information to the spinal motor system, and define the functional roles of spinal interneurons in generating behavior.

Current projects in the lab are highly multidisciplinary, providing candidates with the opportunity to gain extensive training in viral tracing, optogenetics and electrophysiology, whole-brain imaging, single-cell transcriptomics, and quantitative approaches to behavior. We welcome applicants from diverse backgrounds that would thrive in a highly collaborative, fun, and supportive environment that provides the freedom to independently develop a research project.

Application Deadline: Open Until Filled

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6. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The ideal candidate is familiar with high throughput screening and associated data analysis and quality control, and capable of developing/utilizing novel bioassays to solve challenging biology problems. The Scientist reports to the Director of HTB Center and is expected to independently lead and implement collaborative projects; present or publish research results; and assist the Center Director in managing the daily operation of the Center.

Application Deadline: Open Until Filled

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7. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

A postdoctoral position is available in the McKinney-Freeman laboratory of the Department of Hematology at St. Jude Children’s Research Hospital (Memphis, Tennessee, USA) to study hematopoietic stem cell (HSC) function during chronic hematologic disease. HSCs represent the most therapeutically exploited adult stem cell compartment, used routinely to treat leukemia and hematologic disease via HSC transplantation.

Indeed, HSC transplantation represents the only cure for Sickle Cell Disease, including autologous HSC transplantation combined with gene therapy. Here, our major goals are to better understand how elevated hematopoietic demand and chronic inflammation associated with Sickle Cell Disease perturbs the phenotype and function of HSCs. We employ both genetic mammalian model systems and primary patient samples to pursue these aims.

Application Deadline: Open Until Filled

More Details

8. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

A postdoc position is available immediately in the laboratory of Dr Daniel Blair which focuses on the automated synthesis and study of protein reactive small organic molecules. A suitable candidate will have a background in synthetic organic chemistry. Experience with automated synthesis or liquid chromatography mass spectrometry is desirable but is not a requirement. The project will be executed in the Department of Chemical Biology and Therapeutics at St. Jude Children’s Research Hospital and builds on strong investments into a world-class infrastructure in chemical synthesis and chemical biology. Substantial resources have been deployed within the Blair laboratory to support this project including an automated synthesis machine and fully automated preparative LC-MS.

Application Deadline: Open Until Filled

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9. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Tsai Laboratory is seeking dynamic and creative candidates for a fully supported postdoctoral fellowship on genome editing technologies for therapeutic treatment of genetic disorders. CRISPR genome editors, adapted from bacterial adaptive immune systems, are transforming both basic biological research and genomic medicine. At St. Jude, we are working toward advancing these technologies towards patient treatments for sickle cell disease and bone marrow failure disorders.

Application Deadline: Open Until Filled

More Details

10. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

An exciting career opportunity is available for a postdoctoral researcher in the laboratory of Dr. Andrew Davidoff to explore novel gene therapy and small molecule techniques in the treatment of solid tumors. The Davidoff lab seeks an inventive researcher to develop novel gene therapy vectors and test them in our translational models of neuroblastoma and liver cancers. The ideal candidate will have experience with models of solid tumors and/or AAV-based gene therapy vectors, to seek innovative cures for rare pediatric cancers.

Application Deadline: Open Until Filled

More Details

11. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Gottschalk Laboratory is seeking a highly motivated and creative candidate for a fully supported postdoctoral fellowship to develop immune-based therapies. Specifically, the research is aimed to develop T-cell-based therapies for pediatric solid tumors. Studies are focused on using genetic engineering approaches to not only render immune cells cancer specific, but also improve their effector function. Genetically modified immune cells will be studied in preclinical models with special emphasis on how adoptively transferred cells interact with tumor cells, the tumor microenvironment, and resident immune cells. Ultimate goal of these studies is to translate these approaches into early Phase clinical testing.

Application Deadline: Open Until Filled

More Details

12. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Schultz-Cherry laboratory at St. Jude Children’s Research Hospital is seeking a postdoctoral fellow with a strong background in transcriptional mechanisms contributing to B cell longevity and antibody responses during infections and vaccinations to study immune responses and viral evolution in vulnerable populations. The ideal candidate will also have experience working with respiratory viruses in vitro and in vivo, flow cytometry, immunological assays, metabolic assays, as well as isolation and characterization of B cells.

Application Deadline: Open Until Filled

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13. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The PTC is a multidisciplinary team with expertise in structural biology workflow and biophysics. The PTC works with several investigators in the department and across the hospital and is responsible for cloning, construct optimization, protein purification, biophysical studies and structure elucidation. This job is a bench-based scientist role where you will conduct experiments, interact closely with other scientists and investigators, and participate in collaborative research toward understanding the basis of disease.

Application Deadline: Open Until Filled

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14. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The candidate is responsible for the operation and maintenance of the SPR instruments; and should independently plan, optimize and execute experiments to measure the kinetic and equilibrium binding constants. S/he will explore, develop, and apply new methods and technologies to understand the protein-ligand interactions. The candidate will be interacting closely with other scientists and investigators and participating in collaborative research towards understanding the cell functionality and mechanism of disease; should also be willing to train postdocs and other staff members on the instruments.

Application Deadline: Open Until Filled

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15. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Advance hope, medical science, statistical science, and your career as a postdoctoral fellow in the Department of Biostatistics at St. Jude Children’s Research Hospital. As a fellow you will join our faculty in the Department of Biostatistics in providing statistical support and developing innovative statistical methods for research projects at the cutting edge of biomedical research. A position is available in statistical research to develop and improve individualized treatment rules using machine learning methods on electronic health records data and clinical trial studies.

Application Deadline: Open Until Filled

More Details

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The post 15 Postdoctoral Fellowships at St. Jude Children’s Research Hospital, Tennessee, USA appeared first on FellowshipBard.

1. Postdoctoral Position in Cell & Molecular Biology

Summary of Postdoctoral Fellowship:

A postdoctoral (Scientist) position is available immediately in the Chang lab in the Department of Cell & Molecular Biology at St. Jude Children’s Research Hospital. We are looking for highly talented, self-motivated individuals passionate about how cells function as integrated units. In particular, the candidate will utilize cutting-edge light and electron microscopy tools together with genome-editing, biochemistry and in vitro reconstitution to interrogate the fundamental questions of inter-organelle communication. Interested applicants should send a CV, cover letter describing why they are interested in working in our lab, and the names and address of 3 references to Chi-Lun.Chang@stjude.org.

Application Deadline: Open Until Filled

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2. Postdoctoral Position in Pediatric Neurological Disorder Research

Summary of Postdoctoral Fellowship:

The McKinnon lab within the CPNDR has postdoctoral positions to study the pathogenesis of pediatric neurological disease. The lab employs state of the art molecular neuroscience and multi-omics approaches to understand the mechanistic bases of various neurodegenerative syndromes arising from defective genome maintenance. Available postdoctoral projects include understanding the pathogenesis of genome instability induced neuroinflammation in a model of Aicardi Goutières syndrome (see Neuron, PMID: 34655526), the role of genome architecture in determining susceptibly of specific neural populations to genome damage (see Science Adv., PMID: 34910524) and elucidating the critical role of genome maintenance during neurogenesis (e.g see PMIDs 27630045, 30538199, 24793032, 26290337). Interested individuals with an extensive neuroscience background who are experienced in current molecular biology techniques are encouraged to apply. Please email a CV including the names of three references to: peter.mckinnon@stjude.org

Application Deadline: Open Until Filled

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3. Postdoctoral Position in Infectious Disease

Summary of Postdoctoral Fellowship:

St. Jude is seeking outstanding candidates for postdoctoral fellowship positions in infectious disease therapeutics. This NIH sponsored training program has been designed to leverage the outstanding research infrastructure at St. Jude to train top-tier postdoctoral fellows with the necessary skills to lead independent research programs in the discovery of infectious diseases therapeutics including small molecule and vaccine candidates. Postdoctoral preceptors associated with the program are drawn from the departments of Infectious Diseases, Structural Biology, Chemical Biology & Therapeutics, Immunology and Pharmaceutical Sciences, bringing complementary expertise to this enterprise that not only seeks to understand the biology of infection but also strives to develop therapies to combat them.

This expertise includes structural biology, virology and bacteriology, microbial genomics, drug discovery, high-throughput screening, medicinal chemistry, immune responses to infection and therapies, and vaccine platforms and adjuvants. All trainees will be instructed in grant writing, rigor and reproducibility, ethics and mentoring. Short-term internships in pharmaceutical companies or visits to international clinical sites in conjunction with the SJCRH Global Program are integral parts of the curriculum.

Application Deadline: Open Until Filled

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4. Postdoctoral Position in Neurological Disease Research

Summary of Postdoctoral Fellowship:

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5. Postdoctoral Position in Oncology

Summary of Postdoctoral Fellowship:

Dr. Roberts’ research is highly regarded and he has been elected to the American Association of Clinical Research, the Society for Pediatric Research, the American Pediatric Society and American Association of Physicians. He is a passionate mentor and is fully committed to training the next generation of scientists. In addition to being the Director of the NCI designated St. Jude Comprehensive Cancer Center, Dr. Roberts leads a very successful well-funded team with postdoctoral scientists, graduate students, technologists, senior scientists, and a dedicated bioinformatician. You will receive outstanding training in the development of scientific thinking and other skills such as grant writing, manuscript writing, and effective presentation, as well as have the freedom to develop your own ideas in a rigorous and supportive environment. Previous postdocs and graduate student trainees have successfully pursued careers as leaders in academia and industry. A list of previous trainees is available upon request.

Application Deadline: Open Until Filled

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6. Postdoctoral Position in Cell & Molecular Biology

Summary of Postdoctoral Fellowship:

The laboratory of Dr. Bryan Gibson in the Department of Cell and Molecular Biology at St. Jude Children’s Research Hospital invites applications for a Postdoctoral Research Associate to study phase transitions and genome organization. Postdoctoral scientists in the Gibson lab will have the opportunity to become proficient in, and employ, state-of-the-art methodologies in microscopy, genomics, and biochemistry in a scholarly, supportive, and collaborative research environment. They will also have access to core research facilities and substantial resources to aid their pursuit of scientific advances in the fields of chromatin biology and biomolecular condensation. Applicants with interest can explore recent and relevant work published in Nature (DOI: 10.1038/s41586-022-05027-y) and Cell (DOI: 10.1016/j.cell.2019.08.037). Applicants should send (1) a CV with contact information for 3 references and (2) a cover letter describing their scientific journey to Dr. Bryan Gibson (email: bryan.gibson@stjude.org).

Application Deadline: Open Until Filled

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7. Postdoctoral Position in Cell & Molecular Biology

Summary of Postdoctoral Fellowship:

Postdoctoral positions are available in the laboratory of Dr. Stacey Ogden at St. Jude Children’s Research Hospital to research mechanisms of Sonic Hedgehog signaling during development. We are particularly interested in understanding how Sonic Hedgehog ligands use specialized filopodia called cytonemes to travel from their sites of synthesis to activate signaling on distantly localized target cells. Other focus areas in the laboratory include investigations centered on how Sonic Hedgehog signaling is activated in signal-receiving cells and how GLI transcriptional effectors are regulated to ensure appropriate transcriptional responses occur downstream of ligand. We use genetic model systems and cutting-edge imaging technologies to interrogate these fascinating cell biological questions. Prior experience with mouse models and confocal microscopy is preferred, but not required.

Application Deadline: Open Until Filled

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8. Postdoctoral Position in Cell & Molecular Biology

Summary of Postdoctoral Fellowship:

Postdoctoral positions are available in the laboratory of Dr. Stacey Ogden at St. Jude Children’s Research Hospital to research mechanisms of Sonic Hedgehog signaling during development. We are particularly interested in understanding how Sonic Hedgehog ligands use specialized filopodia called cytonemes to travel from their sites of synthesis to activate signaling on distantly localized target cells. Other focus areas in the laboratory include investigations centered on how Sonic Hedgehog signaling is activated in signal-receiving cells and how GLI transcriptional effectors are regulated to ensure appropriate transcriptional responses occur downstream of ligand. We use genetic model systems and cutting-edge imaging technologies to interrogate these fascinating cell biological questions. Prior experience with mouse models and confocal microscopy is preferred, but not required.

Application Deadline: Open Until Filled

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9. Staff Biostatistician (Multiple Openings)

Summary of Postdoctoral Fellowship:

St. Jude Children’s Research Hospital is seeking motivated biostatistics professionals to join our team, and further our life-saving mission. We have multiple positions available within the Department of Biostatistics. Successful candidates will be hired into the career level for which they qualify, based on their education and experience. The Biostatisticians at St. Jude will have a direct impact on the mission of St. Jude by providing statistical expertise to researchers conducting clinical and experimental studies. The Department of Biostatistics is a large department with 14 faculty, 26 biostatisticians, 3 postdoctoral fellows, 8 computing professionals, and administrative staff. Biostatisticians work in teams with a faculty member and sometimes with other biostatisticians to support assigned specific research areas. This approach enables them to gain disease-specific knowledge and expertise while also building productive relationships with collaborators across St. Jude.

Application Deadline: Open Until Filled

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10. Postdoctoral Position in Oncology

Summary of Postdoctoral Fellowship:

The Obeng Laboratory is seeking creative and highly motivated candidates for a fully supported postdoctoral fellowship studying the pathogenesis of myeloid malignancies. The major interests of the lab are determining how acquired mutations in hematopoietic stem cells lead to the development of clonal hematopoiesis, myelodysplastic syndrome, and leukemia, in addition to identifying and studying novel treatments that selectively target malignant clones.

Application Deadline: Open Until Filled

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11. Postdoctoral Position in Developmental Neurobiology

Summary of Postdoctoral Fellowship:

The Plummer Lab at St Jude’s is searching for a Postdoctoral Scientist with a strong background in tumor biology and genomics. This position will manage a team of laboratory technicians to process samples for profiling with single cell OMICs and spatial technologies. Our laboratory analyzes various clinical samples with emerging technologies and expect our analysis to lead to high profile publications in top tier scientific journals. The Plummer lab is a site for the Human Cell Atlas where we focus on understanding the development of disease by studying the cells of origin for neurodevelopmental disorders and breast/prostate/ovarian cancer. If you are interested in breakthrough research and implementing new research techniques, protocols and analyse/interpret data, come consider a close cooperation with Dr. Plummer and other Research Scientists including a high level Bioinformatics Team. Please send inquiries to jasmine.plummer@stjude.org

Application Deadline: Open Until Filled

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12. Postdoctoral Position in Computational Biology

Summary of Postdoctoral Fellowship:

The Yu Lab in the Department of Computational Biology is seeking outstanding candidates for a postdoctoral research associate focused on spatial omics and systems immunology. The Yu Lab is interested in developing systems biology algorithms, including NetBID (Du et al., Nature 2018), by integrating multi-omics data at both bulk and single-cell levels, to dissect the intracellular and intercellular network wiring and rewiring in healthy and disease conditions, as well as the underlying hidden drivers, and then translate the discoveries into potential clinical applications.

The candidate will develop computational and systems biology approaches for network and hidden driver analysis from spatial omics data, single-cell omics data (e.g., scRNA-seq, scATAC-seq, single-cell proteomics, and spatial transcriptomics). The successful applicant will work in a dynamic environment, performing integrative analysis of multidimensional datasets in the context of basic immunology and cancer immunotherapy.

Application Deadline: Open Until Filled

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13. Postdoctoral Position in Neuronal Cell Biology – Vevea Lab

Summary of Postdoctoral Fellowship:

A postdoc position is available in the Vevea lab at St. Jude Children’s Research Hospital in the Department of Developmental Neurobiology and Neuronal Cell Biology Division. We are a cell biology lab that leverages advanced imaging and biochemical techniques to examine the synaptic vesicle cycle in the context of basic function, human disease, and aging. Experiments will include live-neuron microscopy (light-sheet, biosensor), ICC (dSTORM), and a new rapid immunoprecipitation technique.

Potential projects include 1) characterization of synaptic organelles (i.e., mitochondria, synaptic vesicles) using newly developed rapid IP technique, 2) acute disruption and characterization of alpha synuclein at the presynapse, and 3) the role of presenilin mutations in the localization and trafficking of synaptotagmin 7. We are a new lab and so this position can shape the future of all research that comes out of the lab. Would you like to use and design novel techniques, use a ton of institute core facilities?

Do you have a passion for neuronal cell biology? Please get in touch with me. St. Jude as an institute is incredibly supportive and offers a signing bonus and a work computer on arrival, among many other competitive benefits. Special instructions: If interested, please send a brief statement about yourself (cover letter) no more than a paragraph and a CV to Jason Vevea (PI) at jvevea@wisc.edu.

Application Deadline: Open Until Filled

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14. Postdoctoral Position in Pharmaceutical Sciences

Summary of Postdoctoral Fellowship:

A post-doctoral position is available in the laboratory of David Rogers in the field of molecular mycology in the area of antifungal drug resistance. The overarching goal of the Rogers lab is to utilize genome-wide and molecular biological approaches to understand the molecular and genetic basis of antifungal drug resistance in pathogenic opportunistic fungi. The long-term goal of this project is to advance the treatment of Candida infections by identifying the molecular mechanisms underpinning antifungal resistance in Candida species and to ultimately use this understanding to design therapeutic strategies to overcome them. Our immediate objective is to fully understand the genetic and molecular basis of antifungal resistance in clinical isolates of C. albicans, C. glabrata, and C. auris.

Application Deadline: Open Until Filled

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15. Postdoctoral Position in Oncology

Summary of Postdoctoral Fellowship:

The Durbin Lab in the Division of Molecular Oncology at St. Jude Children’s Research Hospital studies the fundamental mechanisms that drive children’s cancer. While patient outcomes have improved in some malignancies, pediatric solid tumors in particular continue to be difficult to manage with little improvements over the past decades. For most of these diseases, no targeted therapies are available, and unfortunately, conventional therapies are fraught with toxicities.

With advances in functional genomics, the role of epigenetic enzymes and transcription factor complexes in driving cell lineage and cancer pathogenesis has come to the forefront. These represent new approaches to controlling high-risk childhood solid tumors, such as neuroblastoma. These processes are made more complex by the presence of intratumoral heterogeneity – the presence of cells in distinct states, within a complex primary tumor (Cell Reports Medicine 2022). Understanding the basic principles of how these cells interact to control growth of a tumor is critical to the successful design of new therapeutic interventions for childhood cancer (Molecular Cell 2020).

Application Deadline: Open Until Filled

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16. Postdoctoral Position in Pharmaceutical Sciences

Summary of Postdoctoral Fellowship:

The laboratory of Dr. Peijun Ma in the Department of Pharmacy and Pharmaceutical Sciences in St. Jude Children’s Research Hospital, Memphis, TN is a new research group that uses single-cell genomics and transcriptomics to study antibiotic resistance and persistence in bacterial pathogens. Past work has focused on developing bacterial single-cell RNA sequencing technology and understanding the evolution of antibiotic resistance in gram-negative bacterial pathogens.

Application Deadline: Open Until Filled

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