Howard Hughes Medical Institute (HHMI), Maryland, USA invites multiple online application for Postdoctoral Positions in various research areas. Candidates interested in Postdoctoral Fellowships can check the details and may apply as soon as possible.
1. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
The Wang (Shaohe) Lab at HHMI Janelia is looking for a postdoctoral researcher to lead projects that investigate how mammalian organs are built by cells and extracellular matrices. The lab uses multiple approaches, including live imaging, sequencing, spatial transcriptomics, genetic perturbation, targeted protein degradation, genome engineering, and computational modeling. This position is dependent upon Shaohe Wang joining Janelia in September 2022, and ideally we’d like the successful candidate to start on/after October 2022.
Application Deadline: Open Until Filled
2. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
We have an opportunity for a Research Specialist to join the laboratory of Dr. Barbara Meyer on-site at the University of California at Berkeley in Berkeley, CA. The Meyer laboratory carries out pioneering research on the mechanisms of cell-fate determination, genome editing, the role of chromosome structure and modification in gene regulation, and the molecular evolution of chromosome-wide mechanisms of gene control in the nematode C. elegans, with an emphasis on X-chromosome dosage compensation. Approaches include genetics, genomics, single-molecule imaging, and structural studies including X-ray crystallography.
Application Deadline: Open Until Filled
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3. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
The Matsen group environment is lively yet casual, with a strong emphasis on collaborative work between postdocs, PhD students, interns, and programmers. The Center is housed in a lovely campus on Lake Union a short walk from downtown, and a slightly longer walk from the University of Washington. The Matsen group is in the newly-remodeled Steam Plant building overlooking the lake. We believe that science is for everyone. We have had researchers with a variety of backgrounds and believe in the importance of diversity, equity, and inclusion.
Application Deadline: Open Until Filled
4. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
We are looking for a Research Specialist who will provide project management for Doudna and Savage Lab, as well as critical administrative and coordination work for all scientific projects. The incumbent will assist with tracking deliverables, timelines, project budgets, contracts and subcontracts, project-related events management, outreach, and communications. In addition, the incumbent will work on cross-functional strategic projects to enhance administrative and operational success in the Doudna and Savage Lab. The incumbent will need the proven experience and knowledge to evaluate workplace practices and take responsibility for optimizing existing functions and implementing process improvements critical in an academic environment.
Application Deadline: Open Until Filled
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5. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
We are currently seeking a Postdoctoral Associate within the lab of Dr. John McCutcheon at Arizona State University. The McCutcheon lab studies endosymbiont-to-organelle transitions and associated processes in evolutionary cell biology. We work on non-model insect systems because these animals have the most organelle-like bacterial endosymbionts yet described. Our lab has combined genomics, cell biology, and biochemistry to uncover some remarkable genomic and cell biological parallels between these insect endosymbionts and mitochondria and plastids. We are seeking a new lab member with expertise in a broad range of cell biological and/or biochemical backgrounds to help continue to move the lab in new research directions. Candidates with expertise in protein purification, organelle purification, protein mass spectrometry, cryo-EM, X-ray crystallography, cell culture infection assays, live-cell imaging, confocal or superresolution light microscopy, or other related techniques are encouraged to apply.
Application Deadline: Open Until Filled
6. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
We are currently looking for a Postdoctoral Associate to join the laboratory of Dr. Samara Reck-Peterson at the University of California, San Diego (UCSD) in San Diego, California. This role will join an HHMI and Aligning Science Across Parkinson’s (https://parkinsonsroadmap.org/) -funded project at the Reck-Peterson lab (http://reck-peterson.ucsd.edu) to study the role of LRRK2 in Parkinson’s disease. The project will use ES and iPS cell culture, gene-editing, advanced live-cell imaging, and proteomics to determine the functions of LRRK1 and LRRK2 in normal cells and the role of LRRK2 in Parkinson’s Disease. The lab is also expert in single-molecule biophysics and in vitro reconstitution and we collaborate with the Leschziner lab at UC San Diego to solve protein structures by cryo-electron microscopy.
Application Deadline: Open Until Filled
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7. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
We are currently looking for a Postdoctoral Associate to work in the laboratory of Dr. Jeffrey Magee at the Baylor College of Medicine in Houston, TX. The Magee lab works to understand how brains learn. Specifically, they are investigating how experience shapes activity in the hippocampal-entorhinal loop. A top physiology lab that works mainly with behavior in mice, the Magee lab uses intracellular and extracellular electrical recordings as well as 2-photon optical imaging techniques to record from both single neurons and populations. They also use various opto- and chemo-genetic techniques to manipulate circuits.
Application Deadline: Open Until Filled
8. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
The Zimmer Lab at the University of Virginia studies how complex carbohydrates shape, support and functionalize biological cells and tissues. We are currently seeking an innovative, inventive and self-driven Postdoctoral Associate. The Zimmer Lab uses all the tools of molecular and structural biology as well as biochemistry to study the structure & assembly of cell surface polymers that form extracellular architectures. Many organisms extend their surfaces as protective barriers, to mediate cellular interactions, and to confer mechanical strength. Our research focuses on polysaccharides and how they are synthesized and deposited on the cell surface. We study capsule and biofilm formation in bacteria, cell wall biosynthesis in plants, chitin deposition in arthropods, and extracellular matrix formation in vertebrates.
Application Deadline: Open Until Filled
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9. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
We are currently seeking innovative, inventive, and self-driven Postdoctoral Associates within the lab of Dr. Leemor Joshua-Tor at Cold Spring Harbor Laboratory. The Joshua-Tor lab studies the structure and mechanism of gene silencing pathways as well as DNA replication. To get a complete understanding of how these processes, the team employs structural, biochemical, biophysical and molecular biology approaches to study how key proteins work at the molecular level. More information can be found on their website. The lab enjoys extremely frequent access to a Titan Krios cryo-electron microscope equipped with a Gatan K3 camera. They also have a screening microscope (Talos 120C), and a chameleon system for grid preparation was just installed in addition to Vitrobot and Leica plungers. There is an excellent fully equipped and soon to be upgraded X-ray facility, crystallization robots and fantastic computational resources including high-performance and GPU computers. Combined with the nearby NSLS-II, these are exciting times with exciting capabilities.
Application Deadline: Open Until Filled
10. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
We are currently looking for a collaborative, self-motivated Postdoctoral Associate to work in the laboratory of Dr. Neil Hunter at the University of California, Davis in Davis, CA. The Hunter lab performs world-leading research in reproductive biology, focused on the process of meiosis. The lab synthesizes biochemical, molecular genetics and cell biology approaches, with yeast, mouse and cell/tissue/organ culture models, to understand how chromosomes are accurately distributed into gametes cells. Their major focus is the DNA-repair mechanism called homologous recombination, which is adapted during meiosis to facilitate chromosome pairing and segregation. They strive to understand the molecular mechanisms and regulation of recombination and the influence of genetics and the environment on this essential process, including gender, sexual maturation, aging and chemical contamination.
Application Deadline: Open Until Filled
11. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
The Postdoctoral Associate will conduct research to elucidate the mechanisms and regulation of homologous recombination during meiosis. The chosen candidate will also be expected to collaborate with other group members and extramural scientists when appropriate; and actively contribute and participate within the laboratory group. The primary worksite location is the Hunter laboratory located in Briggs Hall. The chosen candidate will receive extensive specialized training and be afforded ample opportunity to develop an independent research program. This is an excellent opportunity for someone with specific skills, knowledge and experience in one or more of the following areas: biochemistry, proteomics, cell biology, and/or molecular genetics.
Application Deadline: Open Until Filled
12. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
HHMI is currently seeking a Computational Biologist, Bioinformatics for a full-time opportunity to join the ancient DNA research laboratory of Professor David Reich at Harvard Medical School. The Ancient DNA Laboratory focuses on research studying the genetic history of people who lived up to 20,000 years ago. It is comprised of a wet laboratory, housed within Harvard Medical School’s Department of Genetics and a computational genetics research group, housed within both the Harvard Medical School’s (HMS) Department of Genetics and the Department of Human Evolutionary Biology within Harvard’s Faculty of Arts and Sciences (FAS). The research involves building an ancient DNA atlas of humanity, making ancient DNA accessible to archaeologists, leveraging ancient DNA to understand human adaptation, and leveraging an understanding of population history to reduce suffering and disease.
Application Deadline: Open Until Filled
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13. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
We are currently seeking a highly skilled Bioinformatics Specialist I to work full-time in the lab of Dr. Evan Eichler at University of Washington School of Medicine. The Eichler lab is interested in the disease and evolutionary impact of gene duplication and other complex forms of human genetic variation. Specifically, they apply advanced genome sequencing methods to understand how segmental duplications give rise to new genes and recurrent rearrangements associated with the neurodevelopmental delay, including autism.
Application Deadline: Open Until Filled
14. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
The Glaunsinger lab at the University of California, Berkeley has a position open for a postdoctoral associate who will complement and extend our existing expertise. We study how viruses repurpose and alter cellular gene regulation machinery to create an environment favorable to viral replication, as well as how cells respond to viral invasion. We primarily work with oncogenic herpesviruses, although the lab leverages both DNA and RNA viruses to reveal new aspects of gene regulation. Research projects fall under 3 main categories: 1. Viral proteins that broadly restrict host gene expression: their targeting mechanisms, how select transcripts escape this restriction, and how cells sense and respond to infection-induced changes in mRNA abundance. 2. How oncogenic DNA viruses selectively induce and co-opt noncoding RNA by activating RNA polymerase III. 4. Viral mimicry and co-option of mammalian transcription factors.
Application Deadline: Open Until Filled
15. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
We are currently seeking Research Specialist with a strong immunology background to join a dynamic team of researchers for an exciting opportunity in the laboratory of Darrell Irvine, Ph.D. at the Massachusetts Institute of Technology. Engineering approaches grounded in immunology hold the key to the discovery and development of novel treatments for cancer, infectious disease, and autoimmunity. To this end, the overarching goal of the Irvine laboratory is to engineer immunity through a fusion of immunology with biotechnology and materials chemistry, employing a materials science-centric approach to create new therapies based on the controlled modulation of the immune system. The lab’s work toward this goal divides into three complementary themes, all focused on adapting engineering principles to enhance the ability of the immune system to prevent and treat human disease.
Application Deadline: Open Until Filled
16. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
The Genetically Encoded Neuronal Indicator and Effector (GENIE) project develops, tests, optimizes, and collaborates in producing cutting-edge protein-based fluorescent sensors for imaging cellular activity, thus enabling high-resolution monitoring of cellular function in neurons and other cells. The GENIE project employs project team members with expertise in advanced molecular biology, protein engineering, high-throughput cell-based screening, in vivo fluorescence imaging, and image analysis. The Project Scientist will lead a team of scientists from these different disciplines and oversee the cell-based screens to improve sensor functionality as well as the evaluation of these protein-based sensors ranging from in vitro biophysics to in vivo functional imaging. All funding for the project is provided internally by the Howard Hughes Medical Institute.
Application Deadline: Open Until Filled
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17. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
We are seeking a Postdoctoral Associate to work within the shared lab of HHMI Investigator Dr. Tobias Walther and his scientific partner Dr. Robert Farese at Sloan Kettering Institute/Memorial Sloan Kettering Cancer Center in New York City. The Farese & Walther Laboratory studies the mechanisms of lipid metabolism, storage and homeostasis. The lab uncovers the biochemical, physical and cell biological principles that cells use to store lipids and to determine how lipid balance and storage are maintained. The lab also studies how processes of lipid storage affect physiology and disease. For our joint laboratory, we seek an outstanding individual with Ph.D. training in biochemistry, structural biology, cell biology or physiology to study the mechanistic basis of lipid storage in lipid droplets or lipid metabolism in neurodegenerative diseases and cancer.
Application Deadline: Open Until Filled
18. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
The Liu Lab at HHMI Janelia is looking for a postdoctoral researcher to lead projects that investigate gene regulation mechanism in animal development as well as in disease models. The lab uses cutting-edge imaging techniques combined with advanced genomics and genetic perturbations to decode functional links between gene expression, transcription factor dynamics and genome organization.
Application Deadline: Open Until Filled
19. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
A Postdoctoral Associate position is available in the laboratory of Vanessa Ruta at the Rockefeller University to study the structural basis of odor recognition. The Ruta Lab applies a broad multidisciplinary approach to examine olfactory processing in insects, from the biophysical basis for odor detection to the behavioral algorithms underlying olfactory plume navigation. A current focus of the lab is to define the structural and mechanistic basis of odorant signaling in insect olfactory receptors using biochemistry, cryo-EM, computational docking, and functional assays to reveal insight into how this large and highly divergent family of ion channels can recognize the vast chemical world. In recent work, the Ruta lab determined the first structure of an insect olfactory receptor elucidating their basic architecture (Butterwick et al., Nature, 2018) and revealed insight into the structural basis for promiscuous odor detection (del Marmol et al., Nature, 2021).
Application Deadline: Open Until Filled
20. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
We are currently seeking an innovative, inventive and self-driven Postdoctoral Associate within the lab of Dr. Michelle Wang at Cornell University in Ithaca, NY. The Wang lab operates where physics and biology intersect – pioneering single molecule techniques to investigate fundamental biological processes that impact DNA. To foster a diverse, collaborative research setting, we consider candidates from a broad range of backgrounds including single molecule biophysics, biochemistry, chemistry, molecular biology, nanofabrication, and instrumentation. Postdoctoral Associates will undertake creative and rigorous research including in vitro and in vivo approaches to investigate DNA-based biological processes that allow novel, high resolution insights into the molecular mechanics of the cell.
Application Deadline: Open Until Filled
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21. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
Open-source code and software are immensely important to progress in all areas of science. Sharing code allows the same analyses to be performed across labs, facilitates wide-spread use of computational tools that are increasingly important in biology, and enables different groups to build on others’ achievements. Additionally, the transparency that open-source code provides creates trust in results produced by scientific software. Importantly, sharing code successfully requires more than just releasing it as-is under an open license. Only well-designed and well-documented code is easy to reuse or modify for new applications by other developers (developer-friendly); significant effort is required to bring research-based code to this level. Similarly hard is the design of intuitive user interfaces that allow scientists without expert knowledge of the underlying algorithms to use the software (user-friendly). Additional sustained long-term effort is often required to maintain the code over its lifetime and provide user support.
Application Deadline: Open Until Filled
22. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
We recently created the Open Science Software Initiative (OSSI) that is focused on working closely with labs and teams at HHMI Janelia to create impactful open-source software for the broader research community. We are looking for a talented and motivated Scientific Computing Associate (SCA) who is enthusiastic about open-source software development and would like to work on one or more of these exciting projects that rely on web development.
Application Deadline: Open Until Filled
23. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
A Postdoctoral Associate position is available in Dr. Susan Ackerman’s lab at the University of California, San Diego to study the molecular and cellular consequences of disruptions in mRNA translation, RNA homeostasis, and proteostasis in the developing and aging CNS. The Ackerman Lab uses genetic approaches to identify mouse mutations that are associated with brain defects and genetic variants that enhance or suppress neural phenotypes. Their studies have identified novel molecules and molecular pathways critical for neuron function and survival. Their work with funding from HHMI and NIH has provided insight into disorders such as Alzheimer’s disease and cerebellar ataxia.
Application Deadline: Open Until Filled
24. Postdoctoral Positions
Summary of Postdoctoral Fellowships:
We are currently seeking a Postdoctoral Associate within the lab of Dr. Kim Orth at UT Southwestern Medical Center location. The Orth lab is interested in deciphering molecular mechanisms used for signaling by the host and pathogen. We are interested in elucidating the activity of virulence factors from pathogenic bacteria so that we can gain novel molecular insight into eukaryotic signaling systems. In the past, we have discovered mechanisms such as Ser/Thr acetylation, AMPylation, irreversible actin assembly, bacterial phosphoinositide-binding domain mimics, and pore-forming V-ATPase inhibitors. The marine bacterium Vibrio parahaemolyticus is the worldwide leading cause of seafood-borne acute gastroenteritis. For decades, this pathogen has been studied exclusively as an extracellular bacterium. However, recent studies from our lab have revealed the pathogen’s ability to invade and replicate within host cells.
Application Deadline: Open Until Filled
