Are you holding Master’s degree and looking for fully funded PhD positions? University of York, England invites online application for multiple funded PhD Programs / fully funded PhD positions in various research areas.
Candidates interested in fully funded PhD positions can check the details and may apply as soon as possible. Interested and eligible applicants may submit their online application for PhD programs via the University’s Online Application Portal.
1. Fully Funded PhD Position in Chemistry
Summary of PhD Program:
Organometallic catalysis is one of the most vibrant and essential areas worldwide in scientific research, with impact in a broad range of industrially relevant fields such as pharmaceuticals, agrochemicals and materials. Many metal-catalysed reactions rely on the use of precious metals such as palladium, iridium and rhodium; the high cost of these metals and risk of dwindling supply render these processes unsustainable. Attention over the last decade has turned towards the development of more abundant and cheaper base-metals. Major challenges in this field are a lack of understanding and low predictability, thus significantly higher loadings of catalyst are used when compared to precious metals.
Application Deadline: Open until filled
2. Fully Funded PhD Position in Chemistry
Summary of PhD Program:
The principal motivation for the ALBERT mini-CDT is to develop the science, engineering, and socio-technology that underpins the building of a laboratory-based robotic system for use in applied experiments across the physical sciences. Automated laboratory experiments are revolutionizing the way that we conduct synthetic organic chemistry, from a productivity, performance and efficiency perspective. Creating a Chemistry-based eco-system that is cleaner, greener, safer, and cheaper than anything achievable by current conventional techniques and technologies, is a key driver for this research.
Application Deadline: Open until filled
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3. Self Funded PhD Position in SARS-CoV-2
Summary of PhD Program:
Based on preliminary findings, the interdisciplinary team (molecular biology, synthetic and medicinal chemistry, biophysics, X-ray crystallography) will use fragment-based lead generation[2] to discover small molecule inhibitors of the Nsp3 macrodomain, a novel enzyme target that is present in SARS-CoV-2. Ultimately, the results could underpin the development of a new treatment for COVID-19 (and future CoV-related diseases).
Application Deadline: Open until filled
4. Self Funded PhD Position in Medicinal Chemistry
Summary of PhD Program:
A long-standing fundamental challenge in cross-coupling chemistry is the formation of stereodefined carbon-carbon bonds using Csp3-Csp2 Suzuki-Miyaura cross-coupling. Secondary, enantiopure alkyl boron reagents are readily accessible, bench-stable and configurationally stable, and thus can be considered as the ideal cross-coupling partners – the pre-installed stereochemistry can be perfectly translated into the targeted products. However, Suzuki-Miyaura cross-coupling reactions with cyclic systems have been challenging to develop[1,2] – and this topic will be directly addressed in this project, with the focus on bifunctional nitrogen-containing heterocyclic boronates.
Application Deadline: Open until filled
5. Self Funded PhD Position in Chemistry
Summary of PhD Program:
Fragment-based methods are established for the identification of lead compounds in drug discovery.[1] Fragments are small molecules (molecular weight ~150-300) which bind weakly to proteins. However, especially with X-ray crystal structures of protein-fragment complexes, the elaboration of a fragment to designed lead compounds (MW ~400-500) which are strong protein binders, can be achieved. The synthetic chemistry needed to optimise a fragment hit to a lead compound remains a bottleneck in fragment-based drug discovery, as highlighted by Astex recently.[2] This is especially true when optimising along 3-D vectors. As a result, in this project, we will develop a modular synthetic platform that will enable fragments in current libraries[3] to be elaborated into 3-D lead compounds with functionality in defined 3-D vectors. This will complement our previous work on 3-D fragments[4-6] and 3-D building blocks.[7]
Application Deadline: Open until filled
6. Self Funded PhD Position in Chemistry
Summary of PhD Program:
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Application Deadline: Open until filled
7. Self Funded PhD Position in Chemistry
Summary of PhD Program:
We welcome applications from talented individuals interested in applying cutting edge synthetic methods creatively, for the development of new ring expansion reactions for use in large ring synthesis. All of our ring expansion projects are firmly grounded in synthetic organic chemistry and projects are available several different reaction areas. We are willing to consider PhD candidates interested in Cascade Ring Expansion reactions[1], Successive Ring Expansion (SuRE) reactions,[2-6] and Conjugate Addition ring Expansion (CARE) reactions.[7] We are also happy to consider ring expansion projects focused on target synthesis (e.g. natural products) and medicinal chemistry. Candidates are encouraged to contact Dr Unsworth to discuss potential projects informally, in order to help choose a project area that best matches their expertise and interests.
Application Deadline: Open until filled
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8. Self FundedPhD Position in Chemistry
Summary of PhD Program:
We have developed methods (e.g., McGonigal et al., Angew. Chem. Int. Ed. 2022, 61, e202202193) to modify the structures of tropylium rings, allowing us to tune their steric overcrowding by introducing large groups around their periphery. Rather unexpectedly, we recently discovered that as the size of these groups around the tropylium ring is increased, the steric strain reaches a point where the aromaticity is ruptured! (McGonigal et al. Nature Chemistry, 2023, accepted preprint DOI:10.21203/rs.3.rs-1347057/v1). The tropylium ring ‘breaks’ to form a bicyclic ‘Dewar tropylium’ structure. By choosing appropriate groups, we can balance the steric strain and the aromatic stabilisation energy with one another, placing the aromatic tropylium and the Dewar tropylium in rapid exchange, i.e., creating an unprecedented aromatic-to-nonaromatic cyclisation equilibrium.
