Scripps Research Institute, California, USA invites multiple online application for Postdoctoral Fellowships in various research areas. Candidates interested in Postdoctoral Fellowships can check the details and may apply as soon as possible.
1. Postdoctoral Position
Summary of Postdoctoral Fellowship:
The Briney Lab is seeking a Postdoctoral Associate to join us in the Department of Immunology and Microbiology at Scripps Research. We use a combination of advanced single cell multi-omics techniques and sophisticated computational tools to deeply explore the antibody response to emerging infectious diseases. We are looking for a highly motivated individual who will contribute to antibody discovery projects against a variety of viral targets, including Lassa, Ebola, HIV, SARS-CoV-2, influenza and others. The antibodies we discover have potential use as therapeutics or as templates for rational vaccine development.
Application Deadline: Open Until Filled
2. Postdoctoral Position
Summary of Postdoctoral Fellowship:
Postdoctoral Associate position is available immediately at The Scripps Research Institute in the laboratory of Dr. John Teijaro, whose lab is interested in studying the innate and adaptive immune response to acute and persistent viral infections. Immune suppressive environments during persistent/chronic viral infection prevent excessive immune pathology but also impede the ability of the immune system to eradicate infectious virus from the host. Conversely, excessive inflammation during acute viral infections can reduce viral loads but also lead to severe immune pathology and even death.
The focus of the Teijaro Lab is understanding how immune suppressive and pathological environments are generated, maintained and reversed, with a specific focusing on how type 1 interferon (IFN-I) production and signaling regulates these two states. The Teijaro lab is looking at various viral infection models with respect to the above including: LCMV, Influenza, SARS-CoV2 and Measles virus.
Application Deadline: Open Until Filled
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3. Postdoctoral Position in Immunology and Microbiology
Summary of Postdoctoral Fellowship:
A Postdoctoral Associate position is immediately available in the Immunology and Microbiology Department in the laboratory of Dr. Sumit K. Chanda as part of a multi-disciplinary program focused on using a systems-level understanding of innate immunity, immunology, and virus-host interactions. The successful candidate will join a team investigating mechanisms of virus-host interactions, with a focus on utilizing chemical biology and chemoproteomics tools to identify novel host-pathogen interactions that underlie viral infection and to develop novel therapeutic strategies to facilitate pandemic preparedness.
Studies will focus on RNA viruses of pandemic potential, including influenza virus, coronavirus, flaviviruses, and filoviruses. The person filling this position will play an important intellectual, technical, and scientific role in leading projects. The candidate will also assist with the preparation of grant applications and manuscripts, and contribute to additional projects in the lab. (Position supported by NIH funding.)
Application Deadline: Open Until Filled
4. 3-4 Postdoctoral Position in Chemistry
Summary of Postdoctoral Fellowship:
Dr. Ahmed H. Badran’s laboratory at Scripps Research seeks to hire 3-4 highly motivated Postdoctoral Associates to start in 2022-2023. The Badran Lab aims to address technical shortcomings in conserved cellular processes through innovative synthetic/ chemical biology, directed evolution, genome editing and bioengineering approaches. Specifically, we aspire to develop tools for accelerating the evolution of macromolecular biosynthetic machinery and whole organisms.
Application Deadline: Open Until Filled
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5. Postdoctoral Position in Chemistry
Summary of Postdoctoral Fellowship:
Dr. Shannon Miller’s laboratory at Scripps Research is currently seeking talented Postdoctoral Associate candidates. The Miller Lab uses directed evolution and engineering to develop novel technologies for biomolecule delivery, with a focus on improving in vivo delivery of genome editing agents. Areas of exploration encompass non-viral and viral approaches, including engineering viral payload (RNA/DNA/protein), increasing viral packaging limit, exploring natural diversity for new evolutionary starting points, and improving in vivo biomolecule stability.
The candidate would lead efforts towards the creation of bacterial circuits for the improved activity of viral packaging proteins, development of technologies that enable packaging of non-canonical materials, and development and implementation of assays to evaluate the properties of the resulting biomolecules and vectors.
Application Deadline: Open Until Filled
6. Postdoctoral Position in Chemistry
Summary of Postdoctoral Fellowship:
The Ghadiri Laboratory at the Scripps Research, Department of Chemistry, and the Skaggs Institute for Chemical Biology is currently seeking talented Postdoctoral Associate candidates with a strong background in biology, molecular biology, chemical biology, and/or biochemistry. The lab is developing new, general approaches to control the site and timing of enzyme activity. Enzymes have great potential as therapeutic and diagnostic agents due to their high specificity and catalytic activity, but the ability to better control the timing and location of enzyme function would enable the use of a wider variety of enzymes for therapeutic purposes.
Our approach for enzyme programming relies on attaching an enzyme to its small-molecule inhibitor through an allosteric DNA tether. Upon interaction of the DNA tether with its complement strand, the ensuing conformational change activates the enzyme by dislodging the inhibitor from its active site.
We have established the utility of DNA-programmed intrasterically-regulated enzymes in developing constructs for fast, sensitive, and PCR-independent isothermal detection of label-free nucleic acid sequences; carrying out complex logic operations; programming the activity of streptokinase, a clinically-used fibrinogen activator; and specifically killing targeted cancer cells. We are seeking qualified candidates who can join our multidisciplinary team of scientists to lead this broad research effort.
Application Deadline: Open Until Filled
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7. Postdoctoral Position in Immunology and Microbiology
Summary of Postdoctoral Fellowship:
A Postdoctoral Associate position is immediately available in the Immunology and Microbiology Department in the laboratory of Dr. Sumit K. Chanda as part of a multi-disciplinary program focused on using a systems-level understanding of innate immunity, T cell immunology, and virus-host interactions. The person filling this position will play an important intellectual, technical, and scientific role in leading projects.
Application Deadline: Open Until Filled
8. Postdoctoral Position
Summary of Postdoctoral Fellowship:
The Postdoctoral Research Associate will join the Law laboratory to manage and execute the NIH-funded P01 Program “Broadly Effective HCV Vaccine”. The goal of this research program is to develop a vaccine candidate that can elicit potent and broad immune responses against the antigenically variable hepatitis C virus (HCV). The research program involves several laboratories at Scripps Research and the Southwest National Primate Research Center at San Antonio. *Postdoctoral Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a Scripps Research Faculty member. These appointments are normally not renewed beyond a total of five years.
Application Deadline: Open Until Filled
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9. Postdoctoral Position
Summary of Postdoctoral Fellowship:
The Lippi lab at Scripps Research seeks a Postdoctoral Associate as part of a growing team of investigators studying how a class of non-coding RNAs, called microRNAs, instructs brain development. We have developed molecular tools to map and manipulate microRNA-target interactions in specific cell types of the brain. We are now recruiting researchers that want to apply these tools to understand microRNAs mechanisms establishing neuronal identity and wiring neural circuits. Collectively, our work spans multiple disciplines, including tool development, molecular, cellular and system neuroscience. For more information, please visit www.lippilab.org.
Application Deadline: Open Until Filled
10. Postdoctoral Position in Neuroscience
Summary of Postdoctoral Fellowship:
The Peng lab in the Department of Neuroscience at Scripps Research in La Jolla, California has an available Postdoctoral Associate position for an accomplished researcher in computational genomics, statistical genetics, behavior genetics, and/or computational biology to deepen their knowledge in the context of the emerging area of addiction and behavioral genomics. The ideal candidate would be a highly motivated researcher with a quantitative research background. The individuals who are interested in contributing to the following are encouraged to apply: cutting-edge research focusing on the dissection of the complex genetic and epigenetic basis of addiction and related human behaviors utilizing multi-omics data. The Postdoctoral Associate will receive professional and career mentorship along with opportunities to advance their own expertise to become an independent investigator.
Application Deadline: Open Until Filled
11. Postdoctoral Position
Summary of Postdoctoral Fellowship:
An NIH-funded Postdoctoral Associate position is available for a motivated individual to join the lab of Professor Pietro Paolo Sanna at The Scripps Research Institute to study the neurobiology of substance abuse and neuroAIDS. This dynamic multidisciplinary research team uses in vivo, biochemical and genomic strategies including gene expression anlaysis by single cell RNA-Sequencing, electrophysiology and the establishment of neuronal cell types from induced pluripotent stem cells and fibroblasts.
Application Deadline: Open Until Filled
12. Postdoctoral Position
Summary of Postdoctoral Fellowship:
A Postdoctoral Associate position is available in the Lotz laboratory at Scripps Research, La Jolla, California. The Lotz lab focuses on the discovery of molecular and cellular mechanisms that are dysfunctional in spine and joint diseases and other musculoskeletal conditions during early stages of pathogenesis to create a foundation for therapeutic interventions to prevent disease onset and slow progression. Discovery is pursued by the application of multiple Omics technologies (bulk RNA-sequencing, single cell RNA sequencing and spatial transcriptomics). Genes of interest are tested for function using in vitro models and rodent models of arthritis and intervertebral disc degeneration.
Application Deadline: Open Until Filled
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13. Postdoctoral Position
Summary of Postdoctoral Fellowship:
This postdoctoral position is joint between Shirlee Wohl and Kristian Andersen at Scripps Research. We are working on diverse projects using computational genomics approaches and high-throughput experiments to study emerging viruses and the outbreaks they cause, including SARS-CoV-2, Lassa, Ebola, West Nile, and Zika. We use an integrated approach of collaboration and fieldwork in West Africa, technology development, and computational biology to investigate these viruses.
We are looking for a (primarily) computational postdoc to lead exciting new projects at the intersection of bioinformatics, evolutionary biology, and global health. These projects include building on our ongoing work to understand the evolution of SARS-CoV-2 and emergence of variants throughout the pandemic, as well as engaging in ongoing development of computational methods for analyzing wastewater sequencing data.
Application Deadline: Open Until Filled
14. Postdoctoral Position
Summary of Postdoctoral Fellowship:
Multiple fully funded positions for post-doctoral fellows are currently available in the Erb laboratory (Department of Chemistry, The Scripps Research Institute, La Jolla, CA). Our chemical biology group uses discovery chemistry, CRISPR/Cas9-based functional genetic screens, and advanced transcriptional genomics approaches to discover and study drug-like small molecules that therapeutically modulate chromatin regulation and mRNA transcription (see).
We are seeking to hire multiple post-doctoral fellows to lead projects in ligand discovery, chromatin regulation, and cancer biology. Successful candidates will have laboratory experience in biology, chemistry, or computer science and be committed to working in a collaborative, multidisciplinary group with the goal of advancing new chemical tools, genetic insights, and therapeutic hypotheses.
Application Deadline: Open Until Filled
15. Postdoctoral Position in Bacterial Genomics
Summary of Postdoctoral Fellowship:
This postdoctoral position is joint between Shirlee Wohl and Kristian Andersen at Scripps Research and is part of an exciting new cholera consortium led by Africa CDC and Johns Hopkins University, funded by the Bill and Melinda Gates Foundation. We work on diverse projects using computational genomics approaches and high-throughput experiments to study pathogens and the outbreaks they cause, and we are looking for a (primarily) computational postdoc to build on these approaches to lead computational development and genomic analysis projects focused on understanding mechanisms and drivers of cholera transmission on the African continent. This may include improving bioinformatic pipelines, developing new phylogenetic analysis approaches, and analyzing mutational and structural diversity across sequenced cholera genomes.
Application Deadline: Open Until Filled
16. Postdoctoral Position in Molecular Medicine
Summary of Postdoctoral Fellowship:
A Postdoctoral Associate position is available in the group of Dr. Stuart Lipton and Dr. Tomo Nakamura in the Neurodegeneration New Medicines Center and the Department of Molecular Medicine at The Scripps Research Institute, La Jolla, California. The selected candidate will plan and conduct novel research projects that involve a significant amount of cell culture, including human induced pluripotent stem cells (hiPSCs). The successful candidate will assist in designing experiments, perform thorough data analyses and interpretation of results, and have the opportunity to use sophisticated laboratory equipment such as a Nikon confocal microscope, high-throughput screening confocal (ImageXpress), and patch-clamp or LTP electrophysiology rigs.
Application Deadline: Open Until Filled
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17. Postdoctoral Position
Summary of Postdoctoral Fellowship:
We are looking for talented, highly motivated post-doctoral candidates with a strong interest in basic virology and immunology. The successful candidate will join a team investigating mechanisms of virus-host interactions, with a focus on identifying cellular antiviral responses and molecular signatures linked to severe disease. These studies will utilize systems biology, including large-scale technologies (CRISPR/RNAi, proteomics/ chemoproteomics, chemical biology, NextGen Sequencing, etc.), as well as fundamental virology and more traditional cellular/molecular biology and biochemistry-based approaches. The person filling this position is expected to play an important intellectual, technical, and scientific role in projects.
Application Deadline: Open Until Filled
18. Postdoctoral Position in Integrative Structural and Computational Biology
Summary of Postdoctoral Fellowship:
A Postdoctoral Associate position is available in Dr. Lisa Racki’s Lab at the Scripps Research Institute in La Jolla, CA (rackilab.org) for a highly motivated scientist interested in bacterial chromatin and the role of chromatin in regulating bacterial phages. Specifically, this project will use phage and phage-derived tools to characterize the organization, structure, and dynamics of bacterial chromatin in the opportunistic human pathogen Pseudomonas aeruginosa. This project uses an integrative approach to study bacterial chromatin structure at multiple scales, from in vitro biochemistry, to quantitative single cell timelapse imaging using microfluidics, to macroscopic studies of biofilm communities.
Application Deadline: Open Until Filled
19. Postdoctoral Position
Summary of Postdoctoral Fellowship:
The research projects will focus on NK cell responses to infection and malignancy, using mice, humanized mice, and human specimens. Project 1. To develop memory NK cell-based immunotherapies to prevent or cure HIV infection. This work will be performed using in-house generated humanized mice with a competent immune system and human specimens. Project 2. To develop NK cell-based immunotherapies to prevent or cure solid tumors. This work will be performed using genetically engineered lung cancer mouse models and in-house generated patient-derived xenograft models (lung, and pancreatic cancer). Project 3. To understand NK cell responses to respiratory virus infection (mainly Influenza virus) in the context of innate and adaptive immune crosstalk and immune-therapeutics development. The work will be performed using mouse models of influenza virus infection and in vitro assays.
Application Deadline: Open Until Filled
20. Postdoctoral Position
Summary of Postdoctoral Fellowship:
The structural genomics-oriented cell biology laboratory of Dr. William E. Balch in the Department of Molecular Medicine at Scripps Research has an opening for a candidate with an interest in understanding and treating the underlying basis of mono and polygenic diseases impacting the protein fold through genetic variation in the human population. Successful candidates will contribute to the development and application of new approaches to assess the impact of genetic diversity for different gene targets. Skill-sets of interest include expertise in tissue culture, biochemical tools (SDS-PAGE, immunoblotting, ELISA, protein assay) and a good working knowledge of molecular techniques including transfection with plasmids/siRNA for transient protein expression in cell-based reporter systems.
Application Deadline: Open Until Filled
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21. Postdoctoral Position
Summary of Postdoctoral Fellowship:
At Scripps Research, the Lotz Laboratory is studying mechanisms and treatments of intervertebral disc degeneration (IDD) which affects a large population of older individuals and represents the major cause of back pain. The research on disease mechanisms uses human spines and genetic mouse models to investigate changes in cells, genes and proteins that develop during the aging process and the development of IDD. These studies examine cell function, RNA expression patterns using RNA sequencing and single cell RNA sequencing. The studies on treatments of IDD are using viral gene transfer of protective genes in rat models of IDD.
Application Deadline: Open Until Filled
22. Postdoctoral Position
Summary of Postdoctoral Fellowship:
Postdoctoral position is available in Dr. Jiang Zhu’s laboratory for highly motivated candidates who are interested in vaccine development for diverse viral pathogens, such as SARS-CoV-2, HIV-1, RSV, Flu, HCV, Ebola/Marburg, ZIKV, and MERS-CoV. Dr. Zhu holds a joint appointment in the Department of Integrative Structural and Computational Biology (ISCB) and the Department of Immunology and Microbiology at Scripps Research in La Jolla, CA. Dr. Zhu’s laboratory combines structure-based antigen design, protein nanoparticle engineering, animal immunization, single-cell technologies, and immunological analyses to develop and evaluate next-generation vaccines.
Application Deadline: Open Until Filled
23. Postdoctoral Position
Summary of Postdoctoral Fellowship:
The Dr. Lotz lab at Scripps Research is looking for a highly motivated individual with strong background and technical expertise in cell and molecular biology and bioinformatics for our program on transcription factors in joint biology and arthritis pathogenesis. In a newly funded program about mechanisms of joint tissue destruction and joint pain, we are using Omics technologies (RNA-seq, single cell-RNA-seq, ChIP-seq, epigenetic analyses, spatial transcriptomics) to identify dysregulated transcription factors and test candidate genes in vitro and using mutant mouse strains. Genes that are identified to be essential regulators of homeostatic processes or to promote arthritis pathogenesis are tested in viral gene delivery approaches and used in drug screening assays.
Application Deadline: Open Until Filled
24. Postdoctoral Position in Medicinal Chemistry
Summary of Postdoctoral Fellowship:
We are seeking talented synthetic chemists with a passion for medicinal chemistry and drug discovery to join a dynamic, interdisciplinary team of scientists focused on translational research. Postdoctoral researchers in the medicinal chemistry group will work as part of a team of scientists to design, synthesize, and characterize small molecules that represent new therapeutic approaches to address unmet medical needs. The researcher will play a core role in optimizing the potency, pharmacokinetics, safety, and in vivo efficacy of potential drug candidates. The work environment will utilize industry standard cutting-edge equipment/software and foster comprehensive opportunities to learn core concepts of drug development to progress early leads all the way to the clinic.
Application Deadline: Open Until Filled
