Fred Hutchinson Cancer Research Center, Washington invites multiple online application for Postdoctoral Positions in various research areas. Candidates interested in Postdoctoral Fellowships can check the details and may apply as soon as possible.
1. Post-Doctoral Research Fellow, Cell Biology – Nuclear Envelope Budding
Summary of Postdoctoral Fellowships:
A postdoctoral position for a recent enthusiastic PhD graduate is available in the Parkhurst lab at Fred Hutchinson Cancer Research Center. The Parkhurst lab uses multidisciplinary approaches to study dynamic cytoskeleton processes in the regulation of normal developmental events and when mis-regulated in diseases/cancer. We are seeking a highly motivated postdoc candidate interested in investigating nuclear envelope budding/organization in the Drosophila model system. Responsibilities The postdoc candidate will carry out independent research projects on the research area noted above and participate in lab meetings/journal clubs, as well as contribute to the smooth running of the lab. We are looking for candidates that can thrive in a fast paced environment, that value teamwork, that support diversity, and who are great communicators. Salary for this opportunity will be in line with the NIH pay scale.
Application Deadline: Open Until Filled
2. Post-Doctoral Research Fellow, CAR-T cell therapy – Srivastava Lab
Summary of Postdoctoral Fellowships:
The Srivastava lab in the Human Biology Division at Fred Hutchinson Cancer Research Center is recruiting a Post-Doctoral Fellow with expertise in immunology to lead a project developing strategies to counter CAR-T cell exhaustion in solid tumors. The Srivastava lab focuses on using mouse models of human cancer to define the mechanisms limiting the activity of CAR- and TCR-engineered T cells in solid tumors and to develop strategies to overcome these barriers that can be readily translated to the clinic. The candidate would lead a project centered on understanding how dysfunction develops in CAR-T cells in vivo, performing and validating genetic screens to identify regulators of CAR function, and defining inhibitory mechanisms in the tumor microenvironment that could be targeted in combination to durably enhance CAR-T cell activity. The work would involve using methods of molecular biology (cloning, CRISPR/Cas9 gene editing), extensive in vivo work with transplantable and genetically engineered mouse models, multi-parameter flow cytometry, and single-cell genomics.
Application Deadline: Open Until Filled
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3. Post-Doctoral Research Fellow, Cell Biology – Nuclear Envelope Budding
Summary of Postdoctoral Fellowships:
A postdoctoral position for a recent enthusiastic PhD graduate is available in the Parkhurst lab at Fred Hutchinson Cancer Research Center. The Parkhurst lab uses multidisciplinary approaches to study dynamic cytoskeleton processes in the regulation of normal developmental events and when mis-regulated in diseases/cancer. We are seeking a highly motivated postdoc candidate interested in investigating nuclear envelope budding/organization in the Drosophila model system. Responsibilities The postdoc candidate will carry out independent research projects on the research area noted above and participate in lab meetings/journal clubs, as well as contribute to the smooth running of the lab. We are looking for candidates that can thrive in a fast paced environment, that value teamwork, that support diversity, and who are great communicators. Salary for this opportunity will be in line with the NIH pay scale.
Application Deadline: Open Until Filled
4. Post-Doctoral Research Fellow, Barry Lab
Summary of Postdoctoral Fellowships:
The Barry laboratory, within the Fred Hutchinson Cancer Research Center’s Translational Research Program, is looking for a talented post-doctoral fellow with extensive expertise in the realm of tumor immunology. The Barry lab focuses on understanding how the immune system responds to cancer and can be manipulated to treat cancer. Our studies utilize human immunology, murine models of cancer, state-of-the-art imaging techniques, RNA sequencing techniques, and immunological techniques to explore the role of the innate immune system in controlling immune responses to cancer. We focus our research on understanding how the innate immune system, specifically dendritic and natural killer cells, shape immune responses to cancer and patient responses to common immunotherapies (see Barry et al., 2018 PMID: 29942093).
Application Deadline: Open Until Filled
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5. Post-Doctoral Research Fellow – Targeted Protein Degradation – Nabet lab
Summary of Postdoctoral Fellowships:
Dr. Behnam Nabet’s laboratory is recruiting a highly motivated postdoctoral fellow to carry out research in the fields of targeted protein degradation and proximity-induced therapeutics. The goals of our research program are to develop strategies to target cancer drivers by controlling protein homeostasis to gain new biological insights into clinically relevant targets and to advance new therapeutic strategies in cancer. The Nabet lab develops and deploys innovative chemical biology technologies such as the dTAG system to rapidly eliminate target proteins for therapeutic target discovery and validation (Nabet et al., Nature Chemical Biology 2018, Ferguson and Nabet et al., Nature Chemical Biology 2020, Nabet et al., Nature Communications 2020). We are committed to supporting the next-generation of scientists and believe in collaborative science (Nabet, ChemBioChem 2021). This is an exceptional opportunity to join a new team with a committed mentor that is pushing the boundaries of cancer chemical biology.
Application Deadline: Open Until Filled
6. Post-Doctoral Research Fellow – Targeted Protein Degradation – Nabet lab
Summary of Postdoctoral Fellowships:
Dr. Behnam Nabet’s laboratory is recruiting a highly motivated postdoctoral fellow to carry out research in the fields of targeted protein degradation and proximity-induced therapeutics. The goals of our research program are to develop strategies to target cancer drivers by controlling protein homeostasis to gain new biological insights into clinically relevant targets and to advance new therapeutic strategies in cancer. The Nabet lab develops and deploys innovative chemical biology technologies such as the dTAG system to rapidly eliminate target proteins for therapeutic target discovery and validation (Nabet et al., Nature Chemical Biology 2018, Ferguson and Nabet et al., Nature Chemical Biology 2020, Nabet et al., Nature Communications 2020). We are committed to supporting the next-generation of scientists and believe in collaborative science (Nabet, ChemBioChem 2021). This is an exceptional opportunity to join a new team with a committed mentor that is pushing the boundaries of cancer chemical biology.
Application Deadline: Open Until Filled
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7. Post-Doctoral Research Fellow – Emerman Lab
Summary of Postdoctoral Fellowships:
The Emerman lab was awarded an Avant-Garde Award from NIDA to study HIV latency. We have developed a novel screening technology called HIV-CRISPR technology to comprehensively discover the pathways of HIV latency maintenance and establishment. This postdoctoral position will further explore HIV latency by developing new variations of these CRISPR screens and by validating and further exploring mechanisms of the hits. Preference for new PhD with expertise in one of the following areas: chromatin biology, transcription factors, primary T cell culture, or models of HIV latency. Expectation is to develop an independent project within the context of the grant. The responsibilities include those expected at a PhD level, including leading the technical aspects of the study, contributing intellectually to the overall study design, interpreting data, presenting the findings at meetings and writing manuscripts.
Application Deadline: Open Until Filled
8. Post-Doctoral Research Fellow – Emerman Lab
Summary of Postdoctoral Fellowships:
A laboratory in the Human Biology Division at Fred Hutchinson Cancer Research Center is seeking a Post-Doctoral Fellow to work with an interactive collaborative team of scientists investigating the mechanisms of HIV-1 latency using CRISPR screens and validation in primary cell models of HIV latency. The applicant should be well organized, pay close attention to detail, be reliable and motivated to participate in multiple levels of lab activity. The fellow will perform standard routine and investigative laboratory work in support of scientific research specific to HIV latency and CRISPR screens. The Emerman lab was awarded an Avant-Garde Award from NIDA to study HIV latency. We have developed a novel screening technology called HIV-CRISPR technology to comprehensively discover the pathways of HIV latency maintenance and establishment. This postdoctoral position will further explore HIV latency by developing new variations of these CRISPR screens and by validating and further exploring mechanisms of the hits. Preference for new PhD with expertise in one of the following areas: chromatin biology, transcription factors, primary T cell culture, or models of HIV latency.
Application Deadline: Open Until Filled
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9. Post-Doctoral Research Fellow
Summary of Postdoctoral Fellowships:
A postdoctoral position is available in the lab of Dr. James Alvarez in the Translational Research Program at the Fred Hutchinson Cancer Research Center. The Alvarez lab’s research is focused on understanding the cellular and molecular basis of tumor recurrence, with a special emphasis on the biological properties of residual tumors and drug-tolerant persister cells (see Fox et al., Nature Metabolism 2020; Mabe et al., Cell Reports 2020; Walens et al., Nature Communications 2020; and Walens et al. eLife 2019). Our ultimate goal is to develop strategies aimed at specifically killing residual/persister cells in order to prevent cancer recurrence and improve patient survival.
Application Deadline: Open Until Filled
10. Post-Doctoral Research Fellow
Summary of Postdoctoral Fellowships:
We are seeking highly motivated research fellows to join the Fred Hutchinson Cancer Research Center to work with our team on the development of deep learning-based approaches for to sub-classify metastatic prostate cancer based on histomorphological features. Our team includes researchers with expertise in translational applications of AI and computer vision, pathology, molecular biology and genomics. The candidate is expected to interface with senior staff, clinical investigators, and other research fellows during design, development, and testing of algorithms. Fellows should anticipate being involved in all components of database development pertaining to each application, including dataset curation, annotation, and evaluation.
Application Deadline: Open Until Filled
11. Postdoctoral Research Fellow, Hematopoiesis
Summary of Postdoctoral Fellowships:
The Silberstein lab is seeking to recruit a post-doctoral fellow who is interested in pursuing laboratory-based research project. The main goal of the laboratory is to leverage the knowledge of hematopoietic stem cell biology and bone marrow microenvironment in order to develop new therapeutic approaches to promote normal HSC function in bone marrow failure and to prevent development of myeloid malignancies. For the details of our prior work, please see Silberstein et al, Cell Stem Cell 2016, Goncalves, Silberstein et al, Cell 2016).
Application Deadline: Open Until Filled
12. Postdoctoral Research Fellow, Hematopoiesis
Summary of Postdoctoral Fellowships:
The Silberstein lab is seeking to recruit a post-doctoral fellow who is interested in pursuing laboratory-based research project. The main goal of the laboratory is to leverage the knowledge of hematopoietic stem cell biology and bone marrow microenvironment in order to develop new therapeutic approaches to promote normal HSC function in bone marrow failure and to prevent development of myeloid malignancies. For the details of our prior work, please see Silberstein et al, Cell Stem Cell 2016, Goncalves, Silberstein et al, Cell 2016).
Application Deadline: Open Until Filled
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13. Post-Doctoral Research Fellow–J. Zhu
Summary of Postdoctoral Fellowships:
The Zhu Lab in the Vaccine and Infectious Disease Division at the Fred Hutchinson Cancer Research Center is recruiting a Post-Doctoral Fellow to lead a project deciphering protective immune responses against herpes simplex virus infection in human skin.We use state-of-the-art imaging and spatial technologies in combination with in vitro 3-D microfluidic systems to evaluate tissue-based host immune responses to infection. Responsibilities The candidate will investigate tissue resident memory T-cell and its interaction with surrounding microenvironment in the context of human genital herpes infection. This project will require a deep understanding of viral infection and host response in skin. The ideal candidate will also have experience or be interested in microfluidic technology.
Application Deadline: Open Until Filled
14. Post-Doctoral Research Fellow–J. Zhu
Summary of Postdoctoral Fellowships:
The Zhu Lab in the Vaccine and Infectious Disease Division at the Fred Hutchinson Cancer Research Center is recruiting a Post-Doctoral Fellow to lead a project deciphering protective immune responses against herpes simplex virus infection in human skin.We use state-of-the-art imaging and spatial technologies in combination with in vitro 3-D microfluidic systems to evaluate tissue-based host immune responses to infection. Responsibilities The candidate will investigate tissue resident memory T-cell and its interaction with surrounding microenvironment in the context of human genital herpes infection. This project will require a deep understanding of viral infection and host response in skin. The ideal candidate will also have experience or be interested in microfluidic technology.
Application Deadline: Open Until Filled
15. Post-Doctoral Research Fellow, Viral Dynamic Modeling
Summary of Postdoctoral Fellowships:
The Schiffer Group at the Fred Hutchinson Cancer Research Center is seeking to hire a Post-doctoral Fellow to work on mathematical modeling of viral diseases. Particular emphasis will be on SARS Co-V-2 as well as other respiratory viruses. The successful applicant will work with Dr. Joshua T. Schiffer to develop mathematical models that focus on optimizing treatment of viral infections, and in particular curative strategies for HIV and COVID-19. The candidate will also collaborate with laboratory-based virologists, immunologists, oncologists, and clinical investigators from VIDD, to generate datasets appropriate for model testing and validation. The successful applicant will interact with Fred Hutch based faculty outside of VIDD, plus members of the University of Washington faculty in the Division of Virology and Division of Infectious Diseases.
Application Deadline: Open Until Filled
16. Post-Doctoral Research Fellow, Viral Dynamic Modeling
Summary of Postdoctoral Fellowships:
The Schiffer Group at the Fred Hutchinson Cancer Research Center is seeking to hire a Post-doctoral Fellow to work on mathematical modeling of viral diseases. Particular emphasis will be on SARS Co-V-2 as well as other respiratory viruses. The successful applicant will work with Dr. Joshua T. Schiffer to develop mathematical models that focus on optimizing treatment of viral infections, and in particular curative strategies for HIV and COVID-19. The candidate will also collaborate with laboratory-based virologists, immunologists, oncologists, and clinical investigators from VIDD, to generate datasets appropriate for model testing and validation. The successful applicant will interact with Fred Hutch based faculty outside of VIDD, plus members of the University of Washington faculty in the Division of Virology and Division of Infectious Diseases.
Application Deadline: Open Until Filled
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17. Post-Doctoral Research Fellow, Tumor Dormancy and Therapeutic Resistance
Summary of Postdoctoral Fellowships:
A laboratory in Fred Hutchinson Cancer Research Center’s Translational Research Program (Public Health Sciences Division) is looking for a highly motivated Postdoctoral Research Fellow. The candidate would join the Laboratory for the Study of Metastatic Microenvironments (LSM2), directed by Cyrus Ghajar. The LSM2 focuses on understanding the biology underlying disseminated tumor cell (DTC) dormancy (see: Carlson et al., Nature Cell Biology 2019; Ghajar, Nature Reviews Cancer 2015; Ghajar et al., Nature Cell Biology 2013) and uncovering means to eradicate dormant DTCs. Our overarching goal is to develop therapeutically viable approaches to prevent breast cancer metastasis. The broad research area we are interested in exploring is: how the DNA damage response of quiescent cells differs from that of proliferative cells, and the therapeutic implications of these differences.
Application Deadline: Open Until Filled
18. Post-Doctoral Research Fellow, Tumor Dormancy & Metabolism
Summary of Postdoctoral Fellowships:
A laboratory in Fred Hutchinson Cancer Research Center’s Translational Research Program (Public Health Sciences Division) is looking for a highly motivated Postdoctoral Research Fellow to study the metabolism of dormant, disseminated tumor cells (DTCs). The candidate would join the Laboratory for the Study of Metastatic Microenvironments (LSM2), directed by Cyrus Ghajar. The LSM2 focuses on understanding the biology underlying DTC dormancy (see: Carlson et al., Nature Cell Biology 2019; Goddard et al., Nature Cell Biology 2018; Ghajar et al., Nature Cell Biology 2013) and uncovering means to eradicate dormant DTCs. Our overarching goal is to develop therapeutically viable approaches to prevent breast cancer metastasis.
Application Deadline: Open Until Filled
19. Post-Doctoral Research Fellow, Transcriptional Regulation
Summary of Postdoctoral Fellowships:
The Hahn laboratory in the Division of Basic Sciences has an immediate opening for a Post-Doctoral Research Fellow to investigate mechanisms of transcriptional regulation. Examples of potential research topics that build upon recent studies include: probing the roles of transcription factors in orchestrating genome-wide expression, studies on the specificity and mechanisms of transcription coactivators (e.g., Mediator, SAGA, TFIID); investigating mechanisms and specificity of transcription activators. The laboratory uses a wide variety of approaches including molecular genetics, genomics, biochemistry, and computational biology. The precise topic of the research project will be determined jointly with the candidate. Candidates that have a demonstrated interest in gene regulation and that display initiative and creativity will be given priority. The successful candidate will have the ability to work both independently and in a highly collaborative environment.
Application Deadline: Open Until Filled
20. Post-Doctoral Research Fellow, Proteostasis
Summary of Postdoctoral Fellowships:
The long-term aim of research in the Lehrbach lab is to better understand proteostasis mechanisms and their roles in aging, neurodegenerative diseases and cancer. The fellow will work on individual and collaborative projects that use genetic, genomic, and cell and molecular biology approaches to discover new proteostasis mechanisms and reveal their physiological roles. The primary model organism for this work will be C. elegans, however previous experience with C. elegans is not essential.
Application Deadline: Open Until Filled
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21. Post-Doctoral Research Fellow, Pancreatic Cancer Research
Summary of Postdoctoral Fellowships:
A highly qualified and motivated post-doctoral research fellow is sought to join the laboratory of Dr. Sunil Hingorani at Fred Hutchinson Cancer Research Center in Seattle, WA. The Hingorani Lab will be moving to the University of Nebraska Medical Center in Omaha, Nebraska in 2022. This position may therefore start at Fred Hutch in the first half of 2022 and then transition to UNMC before the end of the year. Our laboratory investigates molecular and cellular mechanisms of pancreatic ductal adenocarcinoma (PDA) pathogenesis. The murine models of distinct genetic subtypes of pancreas cancer that we have developed form the basis of our integrated, systematic, and multidisciplinary research program. Our efforts are directed at identifying and overcoming stromal barriers to treatment (including elevated interstitial pressures, activated fibroblasts, and multiple mechanisms of immune suppression); identifying and disrupting molecular drivers of metastasis; and developing immune-based strategies. Our ultimate aim is to reduce our discoveries to practice in the clinic in order to radically transform the approach and prognosis for patients with this devastating disease.
Application Deadline: Open Until Filled
22. Post-Doctoral Research Fellow, Neuroscience/ Neurodegeneration
Summary of Postdoctoral Fellowships:
A postdoctoral fellow position in Neuroscience/Neurodegeneration is available in the Fred Hutch lab of Dr. Linda Buck. Dr. Buck received a Nobel Prize in Physiology or Medicine in 2004 for “Odorant receptors and the organization of the olfactory system”. Current projects in the Buck lab focus on molecular mechanisms that underlie stress, appetite, and neurodegeneration and how they are influenced by the olfactory system. The lab has developed and uses cutting edge technologies to unravel neural mechanisms and neural circuits underlying specific functions/dysfunctions. These include novel genomics methods to define neural circuits, genetic and chemical control of neuronal activation, imaging of gene expression and neuronal activation, gene editing, and single cell genomics.
Application Deadline: Open Until Filled
23. Post-Doctoral Research Fellow, Jerome Lab
Summary of Postdoctoral Fellowships:
The Jerome Laboratory in the Vaccine and Infectious Disease Division at the Fred Hutchinson Cancer Research Center is recruiting one or more Post-Doctoral Fellows to conduct laboratory bench research as well as studies in small animal models to evaluate cure strategies and gene therapy for persistent viral infections including herpes simplex, hepatitis B, and HIV. Responsibilities: Approaches to be used include genome editing, cell culture, flow cytometry, biochemical analysis, next-generation sequencing, and others. The candidate will be also performing in vivo studies in animal models of viral infection. In addition to performing bench experiments and animal studies, the individual is expected to help write manuscripts and grant proposals, and to present research at scientific meetings.
Application Deadline: Open Until Filled
24. Post-Doctoral Research Fellow, Jerome Lab
Summary of Postdoctoral Fellowships:
The Jerome Laboratory in the Vaccine and Infectious Disease Division at the Fred Hutchinson Cancer Research Center is recruiting one or more Post-Doctoral Fellows to conduct laboratory bench research as well as studies in small animal models to evaluate cure strategies and gene therapy for persistent viral infections including herpes simplex, hepatitis B, and HIV. Responsibilities: Approaches to be used include genome editing, cell culture, flow cytometry, biochemical analysis, next-generation sequencing, and others. The candidate will be also performing in vivo studies in animal models of viral infection. In addition to performing bench experiments and animal studies, the individual is expected to help write manuscripts and grant proposals, and to present research at scientific meetings.
Application Deadline: Open Until Filled
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25. Post-Doctoral Research Fellow, Epidemiology
Summary of Postdoctoral Fellowships:
A Post-Doctoral Research Fellowship opportunity is offered under the supervision of Dr. Robert Kaplan, to become part of his interdisciplinary research group. The successful applicant will have the opportunity to pursue independent research and publications through the use of rich epidemiological study resources from major NIH-initiated cohort studies in chronic disease epidemiology. Building upon long term followup of population based epidemiological cohort studies, our group has developed a diverse research portfolio that integrates traditional clinical epidemiological measurements, wearable monitor data (e.g., physical activity, sleep), genetics (GWA, whole genome sequencing), metabolomics, gut microbiome, electronic health records and psychosocial and lifecourse epidemiology approaches. Our areas of research focus include lifestyle behaviors including diet, physical activity and sleep, with a particular focus on the Hispanic / Latino adult and pediatric populations; inflammatory and immunologic determinants of cardiometabolic disease; genetic epidemiology studies among multiethnic populations; nutritional epidemiology; and multi-omics research (genomics, transcriptomics, epigenetics, metabolomics). Projects include the following large multicenter collaborations, among others: Hispanic Community Health Study-Study of Latinos/HCHS-SOL; Women’s Interagency HIV Study/WIHS; Multicenter AIDS Cohort Study/MACS; Nurses’ Health Study; Cohorts for Heart and Aging Research in Genomic Epidemiology consortium/CHARGE, NIH Trans-Omics for Precision Medicine Program/TOPMed.
Application Deadline: Open Until Filled
26. Post-Doctoral Research Fellow, Epidemiology
Summary of Postdoctoral Fellowships:
A Post-Doctoral Research Fellowship opportunity is offered under the supervision of Dr. Robert Kaplan, to become part of his interdisciplinary research group. The successful applicant will have the opportunity to pursue independent research and publications through the use of rich epidemiological study resources from major NIH-initiated cohort studies in chronic disease epidemiology. Building upon long term followup of population based epidemiological cohort studies, our group has developed a diverse research portfolio that integrates traditional clinical epidemiological measurements, wearable monitor data (e.g., physical activity, sleep), genetics (GWA, whole genome sequencing), metabolomics, gut microbiome, electronic health records and psychosocial and lifecourse epidemiology approaches. Our areas of research focus include lifestyle behaviors including diet, physical activity and sleep, with a particular focus on the Hispanic / Latino adult and pediatric populations; inflammatory and immunologic determinants of cardiometabolic disease; genetic epidemiology studies among multiethnic populations; nutritional epidemiology; and multi-omics research (genomics, transcriptomics, epigenetics, metabolomics). Projects include the following large multicenter collaborations, among others: Hispanic Community Health Study-Study of Latinos/HCHS-SOL; Women’s Interagency HIV Study/WIHS; Multicenter AIDS Cohort Study/MACS; Nurses’ Health Study; Cohorts for Heart and Aging Research in Genomic Epidemiology consortium/CHARGE, NIH Trans-Omics for Precision Medicine Program/TOPMed.
Application Deadline: Open Until Filled
