University of Gothenburg, Sweden invites online application for multiple fully funded PhD programs in various research areas. Candidates interested in fully funded PhD positions can check the details and may apply as soon as possible.
1. Doctoral student in Medical Science – Biochemistry
Summary of PhD Positions:
Mitochondria convert chemical energy into ATP by utilizing a system of molecular machines, the respiratory chain complexes. The complexes driving oxidative phosphorylation are a mosaic of proteins encoded by the nuclear and the mitochondrial DNA. Therefore, assembly of the respiratory chain and the ATPase requires not only expression and import of many nuclear encoded proteins but also translation of mitochondrially encoded proteins. The mitochondrial genetic system is responsible for replication and transcription of the mitochondrial genome and for the synthesis of a few polypeptides within the organelle. Dysfunction of these processes underlies many human disorders and aging. It is therefore surprising that so little is known about mitochondrial protein synthesis. The main goal of this project is to unravel how protein synthesis by mitochondrial ribosomes is connected to quality control and proteolysis. Specifically, we will identify how auxiliary factors interact with the mitochondrial ribosome to mediate co-translational protein quality control. Because the respiratory chain is crucial for cellular energy metabolism, defects of mitochondrial gene expression result in severe human diseases. Hence, the information emerging from this study will be relevant for basic as well as for medical sciences. We will employ a combination of protein biochemistry, genetics and high-resolution single particle cryo-electron microscopy to reveal basic molecular mechanisms. For more information see our homepage: www.martinottlab.com
Application Deadlines: 2022-05-24
2. Doctoral student in Medical Science – Function and gene expression of single beta-cells
Summary of PhD Positions:
Type 2 diabetes (T2D) is an escalating health problem of enormous proportions. Although existing drugs reduce hyperglycaemia, they fail to stop the gradual beta-cell failure that is the key determinant of disease progression. There is consequently an urgent need for improved knowledge of the cellular mechanisms that cause beta-cell failure. We have recently demonstrated that human pancreatic beta-cells lose their mature phenotype in T2D. Interesting reports have also shown that there are pools of beta-cells within a pancreatic islet that differ in secretory response to glucose and that the proportion of such pools is altered in T2D. This is yet a largely unexplored area, but the new findings emphasise the need to analyse the single-cell phenotype to better define the exact changes of beta-cell function and expression in T2D and enable treatment that more precisely counteracts secretory failure.
Application Deadlines: 2022-05-31
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3. Doctoral position in practical philosophy, with a focus on economic and/or environmental ethics
Summary of PhD Positions:
Economic ethics is the application of moral or political philosophy to critical issues in business organizations or the economic system. Environmental ethics is the application of moral or political philosophy to critical issues in the relationship between humans and non-human environmental systems. The research area should be understood broadly so as to include subtopics like business ethics, the political philosophy of financial markets, ethics of commodification, ethics of climate change, ethics of biodiversity, environmental philosophy and the philosophy of (environmental) economics. Any applications related to these subfields are welcome.
Application Deadlines: June 13, 2022
4. Doctoral student in Medical Science – Food and IBS
Summary of PhD Positions:
The PhD education in Medical Science comprises carrying out a scientific project and completing at least 30 credits of courses at third-cycle level. The doctoral student must also write a scientific compilation thesis or monograph corresponding to at least 120 credits. For more information about third-cycle studies at Sahlgrenska Academy, see https://www.gu.se/en/sahlgrenska-akademin/doctoral-studies The aim of this PhD project is to characterize mechanisms behind adverse food reactions in the gut in patients with the common bowel disorder irritable bowel syndrome (IBS), with a particular focus on diet-microbiota interactions, and to clinically evaluate the efficacy of different dietary treatment options in this patient group. In the project we will predominantly study clinical aspects of diet and IBS, but also the role of microbiota and local allergy-like reactions in the gut in patients with IBS will be evaluated. The project will focus on clinical management and assessment of patients with IBS, but with close collaboration with research colleagues regarding microbiological and immunological aspects.
Application Deadlines: 2022-06-01
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5. Doctoral positions in Journalism, Media and Communication
Summary of PhD Positions:
Doctoral positions in Journalism, Media and Communication at the Department of Journalism, Media and Communication (JMG). JMG is a nationally leading and internationally renowned center for research on journalism, media and communication. The department’s research profile covers fine areas including Crisis communication, Journalism, Media institutions and audiences; Organizations and communication as well as Political communication. For more information about the department’s research please see https://www.gu.se/en/jmg/our-research/current-research-agenda-and-groups-at-jmg The aim of the doctoral studentship is for the doctoral student to acquire the knowledge and skills necessary to be able to conduct research independently and to contribute to the development of knowledge within the discipline through the production of a thesis. The doctoral student is also expected to develop capacities to pursue continuing scholarly work or other types of qualified professional tasks when the studies are finalized.
Application Deadlines: 30th of August, 2022
6. Doctoral student in Medical Science – T cell immunity to tumors
Summary of PhD Positions:
Unconventional T cells have a conserved T cell receptor and respond instantly to stimulation by cytotoxicity and cytokine production, and may thus be crucial for antitumor immunity. However, the knowledge about unconventional T cells is still scarce, especially in cancer settings. The novel checkpoint blockade therapy has improved tumor immunotherapy considerably, but many tumor types, among them colorectal cancer (CRC), still respond poorly and new treatment options are urgently needed. The aim of this proposal is to evaluate the contribution of unconventional T cells to tumor immunity. We will use tissue material from CRC patients to perform a detailed and unbiased evaluation of subpopulations of mucosal-associated invariant T (MAIT) and gd T cells in the tumor microenvironment. In particular, production of anti- or pro-tumorigenic cytokines and cytotoxic potential will be determined in different settings. Studies will also be performed to investigate how the tumor microenvironment affects unconventional T cell function and the effect of blocking inhibitory receptors on unconventional T cells. The possibility to use unconventional T cells for immunotherapy, either by directly administering expanded cells or by modulating the function of endogenous, tumor-infiltrating cells has not yet been properly evaluated, but is likely to open new avenues for cancer treatment.
Application Deadlines: 2022-06-14
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7. Doctoral student in Medical Science – The effect of GLP-1 analogues in the brain
Summary of PhD Positions:
Project title: GLP-1 analogues in treatment of obesity: New light on the hypothalamus The Department of Physiology is located at the Institute of Neuroscience and Physiology at the Faculty of Medicine at Sahlgrenska Academy, University of Gothenburg. The Department conducts research within the area of physiology. Several projects involve a close collaboration with the Sahlgrenska University Hospital. We offer undergraduate courses as parts of study programs in Medicine, Dentistry, Pharmacy, Speech and language pathology, Dental hygiene, Occupational therapy, Physiotherapy and the bachelor program of Cognitive Science. The research groups at the Department represent a broad range of research areas within the field of physiology.
Application Deadlines: 2022-06-14
8. Doctoral student in Medical Science – Rheumatoid arthritis and anti-PD1 induced arthritis
Summary of PhD Positions:
The PhD education in Medical Science comprises carrying out a scientific project and completing at least 30 credits of courses at third-cycle level. The doctoral student must also write a scientific compilation thesis or monograph corresponding to at least 120 credits. For more information about third-cycle studies at Sahlgrenska Academy, see https://www.gu.se/en/sahlgrenska-akademin/doctoral-studies Project: Rheumatoid arthritis is a chronic autoimmune disease characterized by inflammation in the synovia that can lead to destruction of cartilage and bone if the disease is not treated early and with optimal therapy. Treatment of cancer with the immune checkpoint inhibitor anti-PD1 can lead to development of inflammatory arthritis that resembles rheumatoid arthritis. There are multiple gaps of knowledge regarding the function and utility of PD1 in these rheumatologic diseases. Our hypotheses are that PD1-positive T cells and soluble PD1 can be used to predict treatment response in early RA, and that PD1-positive T cells and soluble PD1 have a pathogenetic role in anti-PD1 induced arthritis. We can address these questions by clinical and experimental data from two unique patient cohorts. The first is the NORD-STAR study, a large Nordic randomized treatment study in untreated early RA, and the second is a longitudinal cohort of patients with arthritis induced by anti-PD1 treatment at Rheumatology and Oncology, Sahlgrenska University Hospital.
Application Deadlines: 2022-06-14
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9. Doctoral student in Medical Science – The cholinergic anti-inflammatory pathway and its role in atherosclerosis
Summary of PhD Positions:
Cardiovascular disease, manifested as myocardial infarction and/or stroke, is the leading cause of mortality and morbidity globally. The underlying factor for cardiovascular disease is usually atherosclerosis. Inflammation is central in cardiovascular disease, not only for the pathogenesis of atherosclerosis, but also in complications following atherosclerosis, for example during and after embolus/thrombus formation, i.e. myocardial infarction. Autonomic dysfunction is a well-known risk factor for cardiovascular disease, yet, the mechanisms linking autonomic dysfunction to atherosclerosis remain elusive. In this PhD project we address the interaction between autonomic nervous system function and inflammation, focusing on cholinergic alpha 7 nicotinic receptor (a7nR) signaling and identification of the mechanisms of a7nR action and the mediation of its anti-inflammatory effects. By combining experimental models and human material we will identify the mechanisms whereby the α7nR modulates inflammation and thereby influences the development of atherosclerosis. In sum, focusing on the role of α7nR in atherosclerotic cardiovascular disease is a novel and unique approach for addressing the pathogenesis of this disease. This research program will lead to better understanding of the pathology of atherosclerosis, thus, potentially enabling new preventive and therapeutic treatment strategies.
Application Deadlines: 2022-06-14
10. Doctoral student in Medical Science – Developmental Neuroscience
Summary of PhD Positions:
Children born prematurely have an increased risk of infections, which can contribute to long-term neurological complications, but the mechanisms are unknown. The bacterium Staphylococcus epidermidis (SE) is the most common infection in premature babies. In studies in neonatal mice, we have discovered that SE infection reprograms the transcriptome in microglia (the brain’s immune cell) and identified the activation of pyroptosis, a recently discovered cell death mechanism. The overall purpose of the doctoral project is to investigate pyroptosis in the brain after nenonatal SE infection and apply the new knowledge to investigate new brain-protective treatments. The doctoral student will receive broad education in several research disciplines and methods, including physiology, microbiology, neuroscience, neuropathology, experimental animal knowledge and behavior, advanced imaging techniques, flow cytometry and immunofluorescence.
Application Deadlines: 2022-06-14
11. PhD student, specializing in analyzing innovation processes for new sustainability technology
Summary of PhD Positions:
The project will study the innovation processes leading to new technologies and related businesses, which address sustainability challenges such as SDGs. The purpose of the project is to analyze knowledge-intensive innovation processes involving new technologies in businesses – and these processes may include universities, entrepreneurship and large companies – in Nordic countries which promote sustainability goals. An example of such technologies is carbon capture. Innovators and entrepreneurs need to develop and use new scientific and engineering knowledge, along with identifying business models, in order to further develop technologies which will help solve environmental problems. Moreover, sustainability standards provide a useful point of reference for decisions regarding business relationships to thereby help re-purpose some existing infrastructure such as petroleum pipelines for use to solve environmental challenges. The focus will be upon how innovators and entrepreneurs act, relative to the threats and opportunities for dissemination and application of new technologies which can address the societal sustainability goals. Methods include case study with extensive interviews, across at least 2 Nordic countries.
Application Deadlines: 2022-06-03
12. PhD student, specializing in analying university students’ impact on innovation
Summary of PhD Positions:
The project addresses how universities through prior students impact innovation and entrepreneurship in business. The purpose of this project is to analyze the impacts of university students, with a particular foci upon the flow and career paths of alumni. Alumni are students who have received advanced university degrees. One of the included sub-projects compares and contrasts different groups of alumni. One group has advanced university degrees from engineering/ natural science and the second group with degrees from innovation/ entrepreneurship. A second included sub-project focuses specifically upon graduate students who are active simultaneously in both firms and universities, known as ‘dual affiliation’ or ‘industrially related’ students. The overall project as well as sub-projects thus examine how these different groups of alumni later impact innovation in large firms and entrepreneurship in smaller firms. Methods include developing and analyzing large-scale data, specifically register data as well as planning and conducting surveys of alumni.
Application Deadlines: 2022-06-03
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13. PhD student in Physical sciences, specializing in physical geography
Summary of PhD Positions:
Palsa mires are a habitat type consisting of raised mounds or plateaus of peat with a permafrost core that form primarily in the sporadic permafrost regions of the subarctic. Climate change has led to thawing of permafrost in palsa mires around the Arctic. Around 2000 ha of palsa mires currently exist in Sweden, but high rates of thaw are predicted to lead to the disappearance of palsa mires in Sweden by 2100. As the palsas thaw and degrade, greenhouse gas emissions increase, and habitat for plants and animals is radically changed. This PhD project has the aim to better understand permafrost thaw processes of palsa mires through detailed study of a palsa mire in northern Sweden called Vissátvuopmi. It is a multi-disciplinary project that will combine remote sensing, climate data analysis, ice microstructure analysis, and greenhouse gas flux measurements with the aim to gain deeper understanding of palsa dynamics and their relationship to environmental factors and climatic drivers.
Application Deadlines: 2022-05-31
14. Doctoral student in Molecular Microbiology
Summary of PhD Positions:
Anne Farewell’s group uses molecular genetics and high-throughput screening to study how bacterial cells respond to stress and more recently has focused on the mechanisms of the spread of antibiotic resistance between bacteria. In this project the role of pesticides as drivers of ABR evolution and transmission to human pathogens will be examined. Despite the widespread use of pesticides (a broad group of agents which act against insects, weeds, bacteria and other pathogens), the role of these agents in promoting antibiotic resistance (ABR) is largely unknown. This project will examine the effect of pesticides on ABR development through linkage or cross-resistance (e.g., shared efflux mechanisms) and their role as drivers of ABR spread between bacteria through promoting conjugation. We will suggest interventions in the form of changes to how pesticides and fertilizers (organic and inorganic) are used in agricultural practices to minimize this risk and promote sustainable farming.
Application Deadlines: 2022-05-26
15. Doctoral student in Medical Science – Immunity to influenza Neuraminidase
Summary of PhD Positions:
The PhD education in Medical Science comprises carrying out a scientific project and completing at least 30 credits of courses at third-cycle level. The doctoral student must also write a scientific compilation thesis or monograph corresponding to at least 120 credits. For more information about third-cycle studies at Sahlgrenska Academy, see https://www.gu.se/en/sahlgrenska-akademin/doctoral-studies The doctoral project will investigate immunogenicity and antigenicity of influenza neuraminidase. Seasonal influenza virus infection still causes significant morbidity and mortality. Influenza also presents the danger of a 1918-like pandemic, with millions of deaths, due to the introduction of a novel antigenic virus from the animal reservoirs. Virions present three surface proteins: hemagglutinin (HA), Neuraminidase (NA) and the ion channel M2e, with the first two being the main targets of neutralizing Abs. While HA-specific immune responses have been studied reasonably well, NA-immunity remains poorly understood.
Application Deadlines: 2022-05-23
16. Doctoral student in Medical Science – Tissue resident memory B cells
Summary of PhD Positions:
The doctoral project will investigate origin, specificity, formation and protective role of mucosal resident memory cells after infection. Viral respiratory infections caused by influenza-, orthopneumo- or corona-virus are major concerns worldwide. Influenza A virus (IAV) is a highly prevalent respiratory virus that causes significant morbidity and mortality in humans. Recently, few studies identified lung memory B cells (Bmem) as critical in preventing IAV reinfection. These tissue resident Bmem appear to have a broader specificity compared to splenic Bmem. Finally, our recent study demonstrated an incredible heterogeneity in Bmem, contrary to the focused serum Ab response we reported previously, yet Bmem epitope-specificity has not been elucidated. A better appreciation of tissue resident Bmem after infection and vaccination is crucial first step in developing mucosal vaccines against respiratory viruses.
Application Deadlines: 2022-05-30
