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15 Postdoctoral Fellowships at University of Pennsylvania, Pennsylvania

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University of Pennsylvania, Pennsylvania, USA invites multiple online application for Postdoctoral Fellowships in various research areas. Candidates interested in Postdoctoral Fellowships can check the details and may apply as soon as possible.

1. Postdoctoral Position in Spatial Omics

Summary of Postdoctoral Fellowship:

We are looking for an exceptionally creative and self-motivated postdoctoral fellow to join us in developing new technologies for spatial omics profiling at the cellular level. The successful candidate will collaborate with internal and external groups to solve challenging biological problems. The work will be multi-disciplinary, combining microchip, microscopy, genomics, and computational analysis to profile genome, epigenome, transcriptome, and proteome within the spatial context of tissues and cells. These novel technologies will greatly improve our ability to study tissue complexity and reveal the salient features of tissue architecture in physiology and disease.

Application Deadline: Open Until Filled

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2. Multiple Postdoctoral Position in Cell and Developmental Biology

Summary of Postdoctoral Fellowship:

Multiple NIH-funded postdoctoral positions are available in the laboratory of Rajan Jain in the Departments of Medicine and Cell & Developmental Biology at the Perelman School of Medicine at the University of Pennsylvania. Our laboratory uses genetic, biochemical, imaging and genomic approaches to decipher how nuclear architecture governs cell fate decisions. Our laboratory routinely utilizes multiple mouse models and ESC/iPSC differentiation strategies. We are part of a vibrant community at Penn, including the Epigenetics Institute, Institute for Regenerative Medicine, Cardiovascular Institute and Center for Engineering and Mechanobiology. We are a highly collaborative group that routinely works across disciplines.

Application Deadline: Open Until Filled

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3. 02 Postdoctoral Position in Genetic Regulation of Skeletal Cells

Summary of Postdoctoral Fellowship:

Two postdoctoral fellow positions are available in the Lefebvre laboratory in the Translational Research Program in Pediatric Orthopaedics at the Childrenā€™s Hospital of Philadelphia (CHOP) Abramson Research Institute. The fellows will elucidate specific genetic and epigenetic mechanisms whereby SOX and other transcription factors interact with one another and with growth factor signaling pathways to govern the commitment of mesenchymal progenitor/stem cells to skeletal lineages and the multi-step programs of osteoblast and chondrocyte differentiation.

The fellows will use cutting-edge approaches in vivo and in vitro, including mouse models and high-throughput ā€˜omicsā€™ approaches. Successful accomplishment of this research is anticipated to deepen fundamental scientific knowledge, increase understanding of mechanisms underlying skeleton malformation and degenerative diseases, and help the fellows launch promising careers as independent research investigators.

Application Deadline: Open Until Filled

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4. Postdoctoral Position in human tumor immunology

Summary of Postdoctoral Fellowship:

We are seeking a highly devoted and enthusiastic PhD or MD/PhD scientist to join our group as a postdoctoral research fellow. He/She will be involved in investigating the role of the inflammatory myeloid cells in the tumor microenvironment and the cellular and molecular mechanisms by which tumor modulates their immune functions in cancer patients. Specifically, the researcher will investigate the role of the tumor-infiltrating macrophages and neutrophils in the regulation of tumor-specific T cell and NK cell responses in lung cancer patients. Also, He/She will investigate the ability of tumor-associated neutrophils and macrophages to regulate anti-tumor antibody-triggered immune responses.

Application Deadline: Open Until Filled

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5. Postdoctoral PositionĀ 

Summary of Postdoctoral Fellowship:

The Heller Lab studies the mechanisms by which epigenetic remodeling regulates gene function, in the context of neuropsychiatric diseases such as addiction and depression. To approach this problem, we directly manipulate histone and DNA modifications at specific genes in vivo, using viral delivery of novel epigenetic editing tools, such as CRISPR/dCas9-fusion proteins. This ā€˜bottom-upā€™ approach allows direct elucidation of the causal relevance of epigenetic remodeling in the brain. Because addiction and depression persist long after cessation of the harmful experience, epigenetic remodeling is an attractive underlying mechanism and presents an intriguing target for therapeutic intervention.

Application Deadline: Open Until Filled

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6. Postdoctoral PositionĀ 

Summary of Postdoctoral Fellowship:

This position at the Childrenā€™s Hospital of Philadelphia (CHOP) will focus on defining translational physiology at birth and associated clinical outcomes for newborns with congenital anomalies. Applicants may include clinical investigators with training in pediatrics or neonatology or early-stage postdoctoral fellows interested in reproductive, perinatal, and pediatric epidemiology. Applicants will have a unique opportunity to conduct research in the world-first dedicated birthplace for babies with congenital anomalies, the Garbose Family Special Delivery Unit (SDU). Over 500 babies are born in the SDU yearly, making CHOP the largest global delivery centers for newborns with conditions including congenital heart disease, congenital diaphragmatic hernia, pulmonary hypoplasia, abdominal wall defects, and neural tube defects.

Application Deadline: Open Until Filled

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7. Postdoctoral PositionĀ 

Summary of Postdoctoral Fellowship:

The Romano Lab at the University of Pennsylvania is recruiting a postdoctoral researcher to develop and apply new methods in computational toxicology using artificial intelligence and techniques from biomedical informatics. We develop knowledge graphs to computationally predict and explain the downstream clinical effects that arise following exposure to environmental toxicants. This postdoc position will involve extending these knowledge graphs to new biomedical data types, and applying graph machine learning (Graph ML) to detect novel adverse outcome pathways. They will also have the opportunity to interact with real-world observational datasets (e.g., Penn’s Electronic Data Warehouse and Biobank resources) to validate the Graph ML predictions.

Application Deadline: Open Until Filled

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8. Postdoctoral PositionĀ 

Summary of Postdoctoral Fellowship:

A position is available in the Mitchell Laboratory of Neurodegeneration for a postdoctoral student to investigate the relationship between lysosomal pathology and neurodegeneration. The research is translational and will focus on identifying pharmacologic and nanoparticle approaches to restore lysosomal function using cell physiology and molecular biology techniques. Assays to detect defects in lysosomal health will be applied to neurons, microglia and/or astrocytes and used to identify successful treatments. The project will also develop novel reporters to indicate lysosomal function. The successful candidate must be driven, adept with current molecular biology tools and be able to write scientific papers.

Application Deadline: Open Until Filled

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9. 02 Postdoctoral Position in epigenetic mechanisms of neural developmental and disorders

Summary of Postdoctoral Fellowship:

The Akizu lab seeks candidates for a postdoctoral position in epigenetic mechanisms of neural developmental and disorders. The applicant must have a recent PhD in relevant fields, research experience in epigenomic (i.e. ChIPseq, Cut&Run, ATACseq, Hi-Cā€¦) OR human pluripotent stem cell culturing and organoid differentiation methods and at least one first author publication in an impactful scientific journal. The ideal candidate must be highly motivated and creative with strong ability to design and carry out experiments with a high level of independence. The successful candidate will work full time in one of our recently funded projects while also collaborating with other lab members and investigators in our institution.Ā 

Application Deadline: Open Until Filled

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10. Postdoctoral PositionĀ 

Summary of Postdoctoral Fellowship:

A Postdoctoral Researcher position is immediately available for a highly motivated applicant in the laboratory of Dr. Daniel Pryma in the Department of Radiology in close collaboration with Dr. Sarah Gitto in the Department of Pathology and Laboratory Medicine at the Perelman School of Medicine, University of Pennsylvania. This is a full-time position with funding for up to five years.

The research focuses on preclinical optimization of a novel poly (ADP-ribose) polymerase (PARP) targeted radiopharmaceutical therapy to treat cancer, including drug-resistant ovarian cancer. A PET imaging companion diagnostic will be developed in parallel as a prognostic biomarker as well as for image-guided treatment planning. Studies will utilize preclinical cell line and murine models to evaluate this highly translational theranostic approach. Candidates will work in a highly interdisciplinary team of clinical and basic science researchers with expertise in radiology, oncology, biology, and immunology.

Application Deadline: Open Until Filled

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11. 02 Postdoctoral PositionĀ 

Summary of Postdoctoral Fellowship:

The Nathanson laboratory invites applications for Post-Doctoral positions at the Perelman School of Medicine, University of Pennsylvania. We focus on cutting-edge translational research in cancer genetics, both in the inherited and somatic genetics of cancer (example publications include Hu et al., NEJM 2021; Maxwell et al., JCO Pres Onc, 2020; Kraya et al., Clin Cancer Res 2019). Expertise and interest in both wet bench studies and bioinformatics is preferred, however applicants with only expertise in bioinformatics would be welcome. The laboratory is highly collaborative and investigates several cancers, among which are hereditary breast cancer (due to BRCA1/2 and non-BRCA1/2 mutations), melanoma, testicular germ cell tumors, and neuroendocrine tumors. Applications for postdoctoral positions are invited across all areas of research, all of which are funded by multiple NIH grants and foundation funding.

Application Deadline: Open Until Filled

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12. Postdoctoral PositionĀ 

Summary of Postdoctoral Fellowship:

A postdoctoral position in human immunology and/or bioinformatics is available immediately in the laboratory of Dr. Michael R. Betts at the University of Pennsylvania Perelman School of Medicine. Our group studies human immunology in the context of various human diseases including HIV, SIV, type I diabetes, and others. With our unique access to human samples, we are using high-parameter flow cytometry and next-generation techniques at single-cell resolution to parse through cellular heterogeneity and understand the roles of various rare cell populations in their contribution to human disease.

Application Deadline: Open Until Filled

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