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10 Postdoctoral Fellowships at Cleveland Clinic, Ohio, USA

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Are you holding PhD degree and looking for Postdoctoral Fellowships? Cleveland Clinic, Ohio, USA invites multiple online application for Postdoctoral Fellowships in various research areas. Candidates interested in Postdoctoral Fellowships can check the details and may apply as soon as possible.

1. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The overarching goal of our research program is to better understand the molecular and cellular mechanisms underlying disease progression and drug resistance in hematological malignancies. Our group is interested in studying oncogenic signaling pathways and metabolic reprogramming in hematological malignancies. We aim to uncover previously unrecognized vulnerabilities for therapeutic intervention.

Our research involves multi-disciplinary approaches including molecular biology, biochemistry, chemical biology, immunology, mouse genetics and CRISPR-based gene editing. Recent relevant papers include Chan et al. Nature 2017 and Chan et al. Nature 2020. In the laboratory, we strive to promote a culture of inclusivity and provide mentorship on scientific growth and career development. The principal investigator will meet with the postdoc on a regular basis to review data, discuss goals and provide feedback and advice.

Application Deadline: Open Until Filled

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2. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Highly motivated individuals with a PhD or MD/PhD in relevant area are encouraged to apply. This training position, under the direct supervision of a Cleveland Clinic Principal Investigator will provide practical training and experience in a research setting. This position is appointed through the Lerner Research Institute. The successful applicant will be able to demonstrate a commitment to research, a collaborative work ethic and strong communication skills, both written and verbal. This program is expected to be completed within 5 years.

Application Deadline: Open Until Filled

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3. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Louveau lab is looking for a motivated postdoc for a funded project on the role of the vasculature in Alzheimer’s disease. A background in Alzheimer’s disease, neurodegeneration and/or mouse behavior would be preferable. Members of underrepresented minorities and LGBTQIA+ community are encouraged to apply.

Application Deadline: Open Until Filled

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4. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

We are seeking an outstanding candidate with strong motivation to fill a post-doctoral position in the field of Molecular Cellular Immunology in Dr. Jayati Basu’s laboratory in the Department of Inflammation and Immunity. The postdoc will study molecular mechanisms regulating immune cell development and function in health and disease using mouse models and clinical samples. The research in the Basu lab focuses on development and functional lineage differentiation of lymphocytes and myeloid cell in thymus, bone marrow and barrier tissues.

Particularly, the lab studies how cytokine, chemokine, other tissue-derived factors and microbiota regulates transcriptional network to control development and function of these immune cells in heath and disease [Nat Immunol. 2021 Aug;22(8):969-982; Oncogene. 2023 Jan;42(5):351-363.; Commun Biol. 2022 Jan 21;5(1):84.; Nature. 2020 Jun;582(7810):109-114.]. The lab is new but well equipped with novel genetically engineered mouse models, in addition the postdoc will have opportunity to work side by side in bench with Dr. Basu.

Application Deadline: Open Until Filled

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5. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The laboratory studies sepsis, using monocytes isolated from human blood. In addition, the laboratory uses cell culture for mechanisms. The mechanisms involve inflammatory, metabolic, transcriptomic and epigenetic targets.

Application Deadline: Open Until Filled

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6. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The research goal is to understand hippocampal neurogenesis and neural circuits that underlie human mental behaviors and disease, with a hope that the outcomes of our research will lead to the development of new therapeutic approaches to prevent, treat, and cure neuropsychiatric (i.e. cognitive deficits, depression, and anxiety) and neurological (i.e. epilepsy and addiction) disorders. A successful candidate will dissect neuronal connectivity and function of hippocampal neural circuits in normal and disease rodent models in molecular, cellular, genetic, and circuitry levels.

Application Deadline: Open Until Filled

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7. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Looking for motivated team players who are interested in or have expertise in transcription regulation, kinase action, and the molecular mechanisms that drive cancer treatment resistance.

Application Deadline: Open Until Filled

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8. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Severe, progressive kidney diseases (CKD) are more common among Black patients than other populations. Variants in the APOL1 gene are strongly associated with excess kidney disease risk in African ancestral communities. The successful candidate will work on a collaborative project between the Sedor, Wessely and O’Toole labs that uses novel iPSC models to discover the pathways that cause APOL1-associated kidney disease and develop the tools to stop, even cure, them.

Application Deadline: Open Until Filled

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9. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Our lab is interested in molecular and cellular mechanisms responsible for smooth muscle cell (SMC) and endothelial cells (EC) phenotypic transitions. We use a combination of animal and cell culture models in combination with the bioinformatics analyses such as bulk and single cells RNA-sequencing to better understand these transitions, with the goal to develop novel therapeutic interventions for stabilizing atherosclerotic plaques in order to reduce the risk of plaque rupture with possible myocardial infarction or stroke.

Application Deadline: Open Until Filled

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10. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Xie lab at Lerner Research Institute at Cleveland Clinic is recruiting enthusiastic and motivated postdoctoral researchers to join us to study genome structure, dynamics and regulatory mechanisms in cancer and infection disease. We integrate cutting-edge super-resolution imaging (Xie et al., Nature Methods, 2020), live cell single molecule imaging (Xie et al., Genes & Development, 2017; Knight, Xie et al., Science, 2015) with modern genomics and genome engineering approaches to study the 4D architecture and dynamics of the mammalian genome (Xie et al., Mol.Sys.Bio, 2021) and the fundamental genome regulatory mechanisms in cancer evolution and infection diseases (King*, Yost*, Xie* et al., Nature, 2021).

We seek to understand how the epigenetic network (e.g., writers, reader, effectors), particularly the BET family proteins, regulate the basic genome structure and function (Xie et al, Nature Genetics, 2022, in press) in human development and diseases with the hope of discovering novel druggable targets to improve cancer therapeutics and to fight against infection. We are also interested in tool development to label, image and manipulate the human genome to improve disease diagnosis and in dissecting the interplay between genome regulation and other fundamental cellular processes (e.g., immune response).

Application Deadline: Open Until Filled

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