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15 Postdoctoral Fellowships at National Cancer Institute, Bethesda, Maryland

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Are you holding PhD degree and looking for Postdoctoral Fellowships? National Cancer Institute, Bethesda, Maryland invites multiple online application for Postdoctoral Fellowships in various research areas. Candidates interested in Postdoctoral Fellowships can check the details and may apply as soon as possible.

1. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Vidigal lab seeking a postdoctoral researcher interested in dissecting small RNA biology using mouse models. Our lab combines mouse genetics with computational, biochemical, imaging, and genomic approaches to gain a comprehensive understanding of the regulatory functions of small RNA in vivo. Current projects focus on the physiological roles of AGO-mediated RNA cleavage. Although this is a highly conserved process—also known as RNAi—its functions in mammals remain poorly understood.

Application Deadline: Open Until Filled

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2. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Neuro-Oncology Branch (NOB) at the National Cancer Institute’s Center for Cancer Research (CCR) is a specialized program focused on the study and treatment of brain and central nervous system (CNS) tumors. We are seeking an outstanding candidate to join our Molecular and Cell Biology (MCB) Program. This position involves investigating the unique metabolic phenotype and molecular signaling in brain tumors. The research aims to systematically explore epigenetic changes in cancers, characterizing critical epigenetic targets within DNA repair, metabolism, and therapy resistance pathways using genetic and biochemical approaches. 

Application Deadline: Open Until Filled

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3. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The KCS group studies the structural and molecular mechanisms of kinase signaling complexes that are linked to human cancers and other diseases, with a long-term goal of developing new therapeutic strategies. Our current research objectives focus on an oncogenic protein kinase PKA fusion J-PKAcα, the RAF family kinases, and the leucine rich repeat kinases (LRRKs). We use interdisciplinary biochemical and structural approaches, including X-ray crystallography and cryo-electron microscopy, to decipher the structure and function of these challenging kinase complex systems. 

Application Deadline: Open Until Filled

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4. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

A postdoctoral fellow position is available in the laboratory of Dr. Yuichi Machida at the National Cancer Institute to investigate how proteases regulate DNA replication and maintain genome stability. The lab focuses on DNA-protein crosslinks (DPCs) and other obstacles that impair replication, with a particular interest in the proteases FAM111A and SPRTN. The successful candidate will use molecular biology, cell-based assays, and biochemical approaches to study the mechanisms of proteolytic DNA repair and replication stress response.

Application Deadline: Open Until Filled

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5. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Monteiro Research Group at the Center for Structural Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health in Frederick Maryland is searching for a postdoctoral fellow in the field of high-throughput fragment screening. Initial applications will be evaluated starting August 15th and the search will remain open until the position is filled. The successful candidate will be expected to start in Fall 2025. Initial appointment is for two years, with the possibility of extension to five.

Application Deadline: Open Until Filled

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6. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Monteiro lab specializes in protein crystallography to drive drug discovery and development, using high-throughput structure and validation pipelines. Our team is highly interdisciplinary, working at the interface between protein crystallography and medicinal chemistry. Current drug targets focus on oncometabolic pathways.

The postdoctoral fellow will work primarily on an oncometabolic target to obtain crystal structures in the presence and absence of small molecules and determine protein inhibition mechanisms. The work will encompass protein expression and purification from bacteria and mammalian cells, activity assay development and structural characterization. Special emphasis will be on dynamic aspects of protein activity, including allostery.

Application Deadline: Open Until Filled

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7. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

We are seeking to fill one position with a post-doctoral fellow. We study the functions of human and viral non-coding RNAs in a tumorigenic virus in order to identify pathways instrumental to viral pathogenesis and potentially lead to discovery of novel antiviral and anti-tumor targets. Currently, we are studying the functional significance of a subset of circular RNAs and human genes that are differentially regulated by viral infection. Some non-coding RNA functions of interest include: regulation of infection, immune evasion, cell cycle regulation, and apoptosis.

Application Deadline: Open Until Filled

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8. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

A postdoctoral position is available in Dr. Steven Cappell’s lab, within the Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute. Dr. Cappell is interested in understanding how signal transduction networks are wired to form logical circuits and to understand how these networks function in space and time to regulate diverse aspects of human physiology. Our approach is to combine live-cell imaging of fluorescent biosensors in single cells with genetic and pharmacological perturbations to identify regulatory mechanisms of signal transduction pathways. In particular, we are interested in understanding how cells make the decision to enter the cell cycle and proliferate and how this decision is perturbed in cancer.

Application Deadline: Open Until Filled

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9. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Cancer Biomaterials Engineering Section at the National Cancer Institute (NCI) is hiring a Postdoctoral Fellow to lead projects in developing implantable biomaterial scaffolds for tissue repair and cancer immunotherapy delivery. The Lab is headed by Dr. Matthew Wolf. It is a multidisciplinary combination of biomaterials science, cancer immunology, and tissue engineering. The Lab studies immune modulatory scaffolds as a local delivery system for cancer immunotherapy after surgery and as 3D scaffolds for building immune competent tumor models in vitro. Naturally derived materials composed of decellularized extracellular matrix are of particular interest.

Application Deadline: Open Until Filled

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10. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

A postdoctoral position is available in the Bladder Cancer Section laboratory headed by Dr. Andrea B. Apolo, MD., within the Genitourinary Malignancies Branch (GMB), Center for Cancer Research (CCR), NCI, NIH in Bethesda, Maryland. This position will be funded by an intramural Cancer Research Training/Visiting Fellowship and will be renewed on a yearly basis for a maximum of 5 years.

Application Deadline: Open Until Filled

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11. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Seeking highly motivated research fellows to join the Molecular Imaging Branch within the Center for Cancer Research at NCI, NIH for development of deep learning-based approaches for histomorphological and molecular characterization of various cancer types. This department includes researchers with focus in translational applications of AI and computer vision in medical image analysis, including both radiology, digital pathology, and other medical imaging fields. 

Application Deadline: Open Until Filled

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12. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

A postdoctoral position is available beginning in late summer in the Surgical Oncology Program, CCR, NCI. Our group, the Laboratory of Neuro-Endocrine Cancer Therapy, is seeking a motivated postdoctoral fellow interested in working at the interface between the application of novel therapeutic development and primary model development. Our laboratory program is dedicated to studying the behavior and growth of aggressive endocrine cancer and identifying novel and effective targeted therapies for personalized treatment of metastatic endocrine cancers.

Application Deadline: Open Until Filled

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13. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

A postdoctoral position is available in the laboratory of Dr. Michael M. Gottesman in the Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute. The M. Gottesman lab has been at the forefront of discovery in the field of multidrug efflux transporter biology since its inception. Transporters that confer multidrug resistance in cancer also prevent drugs from crossing the blood-brain barrier (BBB), creating a formidable challenge for the treatment of brain cancers (PMID: 29643473).

Application Deadline: Open Until Filled

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14. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

A postdoc position is available in Dr. Li Yang’s Tumor Microenvironment and Metastasis Section within the Laboratory of Cancer Biology and Genetics, Center for Cancer Research, NCI, NIH in Bethesda, Maryland. Our group’s research focuses on how cancer cells interact with and adapt to the changing immune microenvironment in metastatic process and therapeutic resistance. We utilize proteomics, single cell sequencing, and functional genomics approaches to identify key regulators. The project investigates the mechanisms of immune microenvironment in tumor dormancy induction, maintenance, and reactivation. We anticipate uncovering the insight in breast cancer metastasis and therapeutic resistance.

Application Deadline: Open Until Filled

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15. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

A post-doctoral position is available with Dr. Lisa Boxer in the Laboratory of Genome Integrity to study chromatin regulation of neuronal development. The Boxer lab uses molecular and genomic approaches to study how mutations in chromatin regulators disrupt neuronal gene expression and lead to neurodevelopmental disorders and cancer. Dr. Boxer is part of a highly integrated, interactive and collaborative research environment that provides an ideal training and mentoring setting for young scientists. Her research group is adjacent to the laboratories of Branch Chief Andre Nussenzweig, Senior Investigators Eros Lazzerini Denchi and Avinash Bhandoola, and Stadtman Investigator Sergio Ruiz Macias.

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