Are you holding Master’s degree and looking for fully funded PhD positions? Ludwig Maximilian University of Munich, Germany invites online application for multiple funded PhD Programs / fully funded PhD positions in various research areas.
Candidates interested in fully funded PhD positions can check the details and may apply as soon as possible. Interested and eligible applicants may submit their online application for PhD programs via the University’s Online Application Portal.
1. Fully Funded PhD Position in Vascular Research
Summary of PhD Program:
This project focuses on the functions of MIF proteins on dendritic cells and T cells. MIF is considered to be an innate cytokine/chemokine which exerts most of its roles by controlling cells of the innate arm of the immune system. However, recent evidence also suggests a critical role for MIF and its homolog MIF-2 in the control of T-cell activity. In the project, these novel unexpected effects will be studied via well-established basic immunological techniques as well as innovative and technologically advanced functional leucocyte assays. Systematic comparison of MIF, MIF-2, and their receptors will lead to an in-depth mechanistic exploration of the currently unknown MIF-family induced interplay of dendritic cells and T cells at the crossroad of the innate and adaptive immune responses.
Application Deadline: Open until filled
2. Fully Funded PhD Position
Summary of PhD Program:
According to the LUNG-SAFE study, 10% of all patients admitted to an ICU and 23% of those requiring mechanical ventilation fulfill the criteria of Acute Respiratory Distress Syndrome (ARDS). ARDS qualifies as a life-threatening disease with significant mortality rates ranging from 15-52% from mild to severe forms despite modern treatment strategies. The high chances of irreversible organ dysfunction due to fibroproliferative remodeling result in clinically non-acceptable morbidity rates. We face a high ARDS prevalence that was dramatically fueled by the recent COVID-19 pandemic and an unmet medical need for the development of future drug candidates to reduce the burden of ARDS to patients and society.
Application Deadline: Open until filled
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3. Fully Funded PhD Position
Summary of PhD Program:
High systolic blood pressure, pulsatile motion and the so called “windsock effect” of the aorta are factors that must be considered when it comes to deployment of stent grafts, especially in the ascending aorta. These forcescan cause distal migration of the stent-graft and therefore increase the risk of unintended coverage of aortic branches and unsuccessful treatment of theunderlying pathology. Currently available options for cardiac output reduction such as “Partial right inflow occlusion” or “Rapid right ventricular pacing” require additional vascular access and material. Therefore, they may hold certain risks.
Application Deadline: Open until filled
4. Fully Funded PhD Position
Summary of PhD Program:
The optimal oversizing percentage of endografts for treatment of aortic pathologies is unknown, with recommendations ranging from 0-30% depending on the type of pathology, stentgraft design, and physician preference. This is becoming increasingly interesting in proximal landing zones in the ascending aorta, after previous open repair.
Application Deadline: Open until filled
5. Fully Funded PhD Position
Summary of PhD Program:
Currently the main limitation of aortic arch devices such as inner branch devices is the wide proximal landing zone, which precludes treatment in more than 50% of cases (Benfor et al 2022 EJCTS). Although placing an extra device in the ascending aorta may increase feasibility in some patients, diffuse enlargement or involvement of the proximal ascending aorta precludes treatment if one does not deal with the ostium of the coronary arteries and the aortic valve. This problem has also been identified by Cardiologists as one of the main limiting factors for TAVI procedures.
Application Deadline: Open until filled
6. Fully Funded PhD Position
Summary of PhD Program:
Penetrating Aortic Ulcers (PAU) are typical focal lesions of the atherosclerotic aorta characterized by the erosion of the intima and elastic lamina with an outpouching shape. 1,2 They are classified together with aortic dissections and intramural hematoma as acute aortic dissections, but differ from other conditions for the typical isolated pattern, specific complications and indication for treatment.3,4 PAU are very often reported in the aortic arch and descending thoracic aorta, whereas the localization in the abdominal aorta is up to 30% and little is known on their natural history, treatment options and outcomes.4,5
Application Deadline: Open until filled
7. Fully Funded PhD Position
Summary of PhD Program:
Measurements of aneurysm size and morphological characteristics after endovascular aortic repair may be complex and time-consuming. Physicians often find themselves compromising quality of imaging evaluation to tackle the high number of visiting patients. Newer software using artificial intelligence, could be used to shorten the time a physician spends evaluating Follow-up CT scans and potentially even eliminate hand-made measurements. Such a process requires validation and deep learning for the respective software to become more efficient.
Application Deadline: Open until filled
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8. Fully Funded PhD Position
Summary of PhD Program:
Hereditary sensory and autonomic neuropathy 9 (HSAN9) is a rare fatal neurological disease caused by mis- and nonsense mutations in the gene encoding for Tectonin β-propeller repeat containing protein 2 (TECPR2). While we previously found that TECPR2 is required for lysosomal consumption of autophagosomes (Fraiberg et al. 2021) and ER-to-Golgi transport (Stadel et al. 2015), it remains elusive how exactly TECPR2 is involved in autophagy and secretion and what downstream sequels arise from defective TECPR2 due to its involvement in these processes. Recently, we addressed these questions by determining which proteins depend on TECPR2 for their trafficking out of the ER and sorting within the cell.
Application Deadline: Open until filled
9. Fully Funded PhD Position
Summary of PhD Program:
De novo mutations in the gene encoding for the beta-propeller protein WIPI4 are causative for beta-propeller associated neurodegeneration (BPAN), an X-linked dominant human disorder characterized by iron accumulations in the brain. BPAN patients show early onset developmental delays with severe intellectual disability and rapid, progressive motor and cognitive regression in early adulthood. BPAN-linked mutations are thought to disrupt the beta-propeller structure resulting in a functional loss of WIPI4.
Application Deadline: Open until filled
10. Fully Funded PhD Position
Summary of PhD Program:
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are progressive fatal neurodegenerative diseases with overlapping clinical symptoms and neuropathological findings. Protein aggregation and neuroinflammation are the two main hall marks for ALS/FTD. We focus on C9orf72 mutation and other genetic forms of ALS/FTD to understand disease pathomechanism (Mori et al, Science 2013, May Acta Neuropath et al, 2014, Zhou et al, EMBO Mol Med 2017, Khosravi, EMBO Journal 2020) and develop mouse models for mechanistic and therapeutic studies (Schludi et al, Acta Neuropath 2017; Zhou& Mareljic et al, EMBO Mol Med 2020; LaClair& Zhou et al, Acta Neuropath 2020).
Application Deadline: Open until filled
11. Fully Funded PhD Position
Summary of PhD Program:
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are progressive fatal neurodegenerative diseases with overlapping clinical symptoms and neuropathological findings. Protein aggregates are an important neuropathological feature in both familiar and sporadic ALS/FTD cases. We have focused on the C9orf72 mutation and other genetic forms of ALS/FTD to understand disease pathomechanism (Mori et al, Science 2013, May Acta Neuropath et al, 2014, Zhou et al, EMBO Mol Med 2017, Khosravi, EMBO Journal 2020) and develop mouse models for mechanistic and therapeutic studies (Schludi et al, Acta Neuropath 2017; Zhou& Mareljic et al, EMBO Mol Med 2020; LaClair& Zhou et al, Acta Neuropath 2020).
Application Deadline: Open until filled
12. Fully Funded PhD Position
Summary of PhD Program:
In this project we will study the cell biological and molecular mechanisms controlling the morphology and tightness of neoplastic vessels of the brain. We will focus on signaling cues for GAM-induced BTB formation. To this end we will inspect GBM biopsies, perform in vitro assays as well as genetic manipulations of mouse models and tumour cells. Read-outs will comprise RNAseq (bulk and single cell), RT-qPCR, flow cytometry, Western blotting, immunohistochemistry and histological inspection. The project aims at improving the efficiency of conventional chemotherapy and new targeted treatments for GBM.
