1. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Beers’ Lab has an existing program funded by NIH, the Department of Veterans Affairs, private foundations, and industry to study the molecular mechanisms that regulate tissue injury and repair in focused on discovery, target ID, target validation, and proof or principal studies aimed at uncovering and exploiting novel pathways to treat fibrotic lung diseases. The postdoctoral fellow can focus the project in any of several related areas (epithelial biology, immunological networks, metabolomics, epithelial-mesenchymal crosstalk, and/or transcriptomics/ proteomics) using 2 novel published models of lung injury and fibrosis.

Application Deadline: Open Until Filled

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2. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

A postdoctoral position is immediately available in Dr. Ling Qin’s laboratory in the Department of Orthopaedic Surgery at the University of Pennsylvania. Our group uses cutting edge histology, 3D imaging, and single cell sequencing techniques as well as mouse models to study bone and cartilage metabolism and skeletal development. A number of exciting projects are available for the candidate to choose from, covering the areas of bone turnover, stem cells, marrow adipocytes, joint biology, and tissue regeneration. Please refer to our recent publications (Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment. Elife e54695; MALPs promote osteoclastogenesis in bone remodeling and pathologic bone loss. J Clin Invest. e140214; Targeting cartilage EGFR pathway for osteoarthritis treatment. Sci Transl Med. eabb3946).

Application Deadline: Open Until Filled

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3. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Postdoctoral position is immediately available for NIH funded research projects to study the biological role of protein modifications and protein isoform diversity in actin cytoskeleton functioning and mouse development. Approaches involving biochemistry, molecular biology, cell biology, live cell imaging, and mouse genetics are used separately and in combination to uncover new pathways regulating intracellular protein targets, with focus on cytoskeleton, cell motility, and signaling.

Application Deadline: Open Until Filled

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4. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

We seek highly motivated researchers who enjoy working in a team while concomitantly desiring to pursue their own ideas in a supportive environment. Desired expertise includes, but is not limited to biophysics, atomic force microscopy, confocal microscopy, mathematical modeling, and evolutionary biology in the context of biofilm research.

Application Deadline: Open Until Filled

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5. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Kevin Johnson Lab is seeking a highly motivated and talented Postdoctoral Researcher to join our team in revolutionizing patient-clinician interaction using multimodal video/audio learning techniques. As a member of our multidisciplinary research team, you will be responsible for developing innovative solutions that enhance the quality, efficiency, and effectiveness of patient-clinician communication. This position offers an excellent opportunity to contribute to cutting-edge research and shape the future of healthcare technology.

Application Deadline: Open Until Filled

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6. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Applications are invited for Postdoc Positions in the Shen Lab at the Perelman School of Medicine (PSOM) at the University of Pennsylvania. These positions will offer opportunities to develop and apply advanced artificial intelligence (AI) and machine learning (ML) strategies for integrative analysis of multidimensional imaging, omics, biomarker and clinical data, with applications to the study of complex disorders such as Alzheimer’s disease (AD) and AD related dementia (ADRD).

Application Deadline: Open Until Filled

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7. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Tan research group is interdisciplinary and highly collaborative, utilizing both computational and experimental approaches to study gene regulation. We have pioneered multiple computational algorithms for regulatory genomics, epigenomics, and network biology. Specific projects will be defined by the candidates (and based on the candidates expertise) and with input from Dr. Tan and our close collaborators at the Center for Childhood Cancer Research CHOP and Abramson Cancer Center at the University of Pennsylvania.

Application Deadline: Open Until Filled

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8. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

We are seeking a self-motivated and enthusiastic candidate for a postdoctoral scholar position. The postdoc will participate in an exciting project that uses various single-cell technologies to understand tumor clonal evolution, transcriptional and epigenetic heterogeneity and signaling within the tumor microenvironment, during standard and immuno therapeutic responses. The project is funded by a recent NCI center grant to establish the center for pediatric tumor cell atlas as part of the Moonshot initiative. The project provides an excellent training opportunity in single cell biology and cancer biology.

Application Deadline: Open Until Filled

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9. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The fellow will elucidate cellular and molecular mechanisms underlying Lamb-Shaffer syndrome, a neurodevelopmental disorder due to SOX5 inactivating variants, and will also seek to develop gene therapy approaches to improve the condition of affected individuals. The fellow will use cutting-edge approaches in vivo and in vitro, including mouse models and human iPSC-derived brain organoid models, high-throughput ‘omics’, and AAV-mediated gene therapy approaches. Successful accomplishment of this research is anticipated to deepen fundamental scientific knowledge and have major translational impact in addition to helping the fellow launch a promising career as an independent research investigator.

Application Deadline: Open Until Filled

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10. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Our research is dedicated to unraveling the contribution of recurrent genomic alterations, both in protein-coding and non-coding regions, to tumorigenesis. Our primary focus is on identifying therapeutic targets and developing combination strategies for the treatment of cancer. To achieve these goals, we have developed a novel computational approach that integrates large-scale genomic, functionomic, and pharmacologic profiles. This innovative methodology has led to the creation of the Functional Cancer Genome data portal, which serves as a comprehensive resource for functionally annotating cancer genomes. The newly funded projects will build upon the novel discoveries generated by the FCG project and will involve in-depth molecular characterization of new epigenetic and immuno-oncology drivers in cancer.

Application Deadline: Open Until Filled

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11. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The postdoctoral researcher will conduct mentored research in pharmacoepidemiology, focusing primarily, but not exclusively, on characterizing the health effects of potential drug-drug interactions. The postdoc will be encouraged to articulate research questions of clinical, population health, and mechanistic importance, design research projects, develop detailed analytic plans, perform analyses, interpret results, effectively communicate results orally and in writing, submit results for publication, and disseminate findings to maximize their impact. The postdoc will be encouraged to work outside of their comfort zone, take on projects that do not have a clear path to completion, and propose solutions to problems encountered. Most postdocs serve as first author of several publications during their time at Penn.

Application Deadline: Open Until Filled

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12. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The postdoctoral researcher will conduct mentored research in pharmacoepidemiology, focusing primarily, but not exclusively, on characterizing the health effects of potential drug-drug interactions. The postdoc will be encouraged to articulate research questions of clinical, population health, and mechanistic importance, design research projects, develop detailed analytic plans, perform analyses, interpret results, effectively communicate results orally and in writing, submit results for publication, and disseminate findings to maximize their impact. The postdoc will be encouraged to work outside of their comfort zone, take on projects that do not have a clear path to completion, and propose solutions to problems encountered.

Application Deadline: Open Until Filled

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13. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Wexler Lab is an exciting, highly collaborative, and interdisciplinary research lab focused on the ethical, legal, and social implications of emerging technologies. We are particularly interested in ethical issues arising from novel neurotechnologies, direct-to-consumer healthcare, and digital medicine. Ongoing research activities in our group involve active collaborations across the Perelman School of Medicine, the larger Penn community, and external institutions.

Application Deadline: Open Until Filled

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14. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The highly collaborative and interdisciplinary P3MB research lab seeks to identify and understand the interrelated clinical, ethical, and policy implications of applying precision medicine to the brain and to translate these discoveries into practice. A particular focus is the movement of gene and biomarker tests from research into practice, including testing remote, video, or telephonic methods of disclosure; the role of neural correlates of consciousness as biomarkers of disease; establishing the value of a “preclinical therapy” and translating that into clinical practice; and advancing the concept of supported decision-making across the trajectory of cognitive decline. Project methodologies are qualitative and quantitative data sources and conceptual work.

Application Deadline: Open Until Filled

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15. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

A postdoctoral fellow position is available in the Lefebvre laboratory in the Translational Research Program in Pediatric Orthopaedics at the Children’s Hospital of Philadelphia (CHOP) Abramson Research Institute. The fellow will elucidate genetic mechanisms whereby specific growth factor signaling pathways interact with transcription factors to control the commitment of mesenchymal progenitor/stem cells to skeletal lineages and the multi-step programs of osteoblast and chondrocyte differentiation. The fellows will use cutting-edge approaches in vivo and in vitro, including mouse models, high-throughput ‘omics’, and AAV-mediated gene therapy approaches. Successful accomplishment of this research is anticipated to deepen fundamental scientific knowledge, increase understanding of mechanisms underlying skeleton malformation and degenerative diseases, and help the fellow launch a promising career as an independent research investigator.

Application Deadline: Open Until Filled

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16. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Ky lab is a National Institutes of Health-and American Heart Association-funded internationally recognized program that focuses on advancing the cardiovascular health of patients living with and beyond cancer through clinical science. The Ky Lab has a postdoctoral position in the field of cardiovascular and cancer clinical epidemiology and data science. This position for a clinical researcher involves the use of large datasets comprised of biomarker, echocardiography, genomic, clinical, social determinants of health and other “-omic” data to understand individual patient risk. The ideal candidate will have a Ph.D. or M.D. with strong experience in epidemiology, data science, and computational and data analysis.

Application Deadline: Open Until Filled

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17. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Volk laboratory invites applications for a postdoctoral position in our comparative breast cancer program at the School of Veterinary Medicine, University of Pennsylvania. The goals of our laboratory are to understand regulatory mechanisms governing dynamic interactions between cells and their surrounding extracellular matrix in the wound healing-fibrosis-cancer progression triad and to apply this knowledge to develop innovative regenerative and oncologic therapies for veterinary and human patients. One-year positions are available immediately with the option to extend an additional 1-3 years. Using a combination of in vitro and mouse models, as well as human, feline and canine breast cancer biopsy samples, we have initiated multiple lines of investigation that will provide insight into how regulation of the collagen fibrillar matrix and its components, specifically type III collagen, inhibits formation of a tumor-permissive microenvironment.

Application Deadline: Open Until Filled

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18. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Miner laboratory studies the role of cytosolic nucleic acid sensors in rare diseases, antiviral immunity, autoimmunity, neurodegeneration, and DNA damage responses. In our laboratory, rare disease research is a starting point to define fundamental biological mechanisms. We also prioritize development of novel therapies for patients with rare monogenic diseases. We have 2 new R01s as well as private funding to support multiple new postdocs.

Application Deadline: Open Until Filled

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1. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Seeking a talented and highly motivated postdoctoral fellow to collaborate on research aimed at reducing the burden of breast cancer, particularly for racial/ethnic minorities, through precision prevention approaches. The postdoctoral fellow will work under the direct supervision of Dr. Anne Marie McCarthy, a cancer epidemiologist at the University of Pennsylvania Perelman School of Medicine in the Department of Epidemiology, Biostatistics, and Informatics. Projects will cover topic areas including breast cancer risk prediction, integration of genetics into breast cancer prevention, evaluation of novel imaging biomarkers of breast cancer risk, personalized screening, and racial disparities in breast cancer. Flexible start date.

Application Deadline: Open Until Filled

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2. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Conn Lab is looking for 1-2 postdocs focused on post-transcriptional gene regulation and the roles of RNA-binding proteins, RNA modifications, and signaling that are rewired during cancer progression. One project is focused on identifying regulators of selective translation and spatial RNA interactions in the cell during drug resistance in prostate cancer (more mechanism to move into translational research later). The other project is looking at adaptive stress responses in pancreatic tumors and will require mouse modeling, tissue analysis, and treatments in vivo. The lab has received two awards, over 3 years of DoD funding for project one and has independent funds for project two.

Application Deadline: Open Until Filled

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3. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Mark Kahn lab in the Perelman School of Medicine (Cardiology) is currently recruiting for a postdoctoral researcher for a grant funded project investigating myxomatous valve disease and the role of flow-responsive signals KLF2 and KLF4 in heart development. The Kahn lab uses complex mouse genetics systems with state-of-the-art biochemical and molecular approaches to understand the novel links between hemodynamic forces and vascular diseases in the arterial and venous system. We have collaborations across Penn, CHOP, and other academic institutions such as Duke, University of Chicago, and Cornell. The candidate should have experience with animal models, generation of transgenic alleles, possess strong molecular biology skills and a desire to explore new technologies including single cell analysis and advanced genetics.

Application Deadline: Open Until Filled

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4. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Seeking a talented and highly motivated postdoctoral fellow to collaborate on research aimed at creating innovative solutions for improving cancer screening and care. The postdoctoral fellow will work under the direct supervision of Dr. Katharine Rendle, a cancer implementation scientist at the University of Pennsylvania Perelman School of Medicine in the Department of Family Medicine & Community Health and Deputy Director of the Penn Center for Cancer Care Innovation. Potential projects cover range of topic areas including lung and cervical cancer screening, global disparities in cancer care, mixed methods research, clinical epidemiological, and evaluation of large-scale pragmatic trials. Summer 2023 Start Date (with some flexibility).

Application Deadline: Open Until Filled

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5. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

We are seeking a Postdoctoral Researcher with computational background who is interested in being an integral member of an interdisciplinary program across human and model systems genetics. The Postdoctoral Researcher’s work will focus on human genetics, statistical genetics, and phenotype data. Specifically, the Postdoctoral Researcher will employ bioinformatic approaches, including machine learning and innovative statistical methods, on whole genome sequence and quantitative phenotypic data to discern novel genotype-phenotype relationships in autism.

Applicants are expected to have experience with coding, bioinformatic/computational approaches and genomic analysis. The researcher may also assist in the analysis of clinical trial data. The candidate will work closely with ASPE principal investigators and leadership team to develop a rigorous and cutting-edge research agenda that prepares the Postdoctoral Researcher for his/her next career steps. Joining ASPE affords you with a unique cross-disciplinary training experience in collaborative science and access to a wide range of professional development activities.

Application Deadline: Open Until Filled

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6. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Our lab at The University of Pennsylvania is seeking an enthusiastic, dedicated, and highly motivated Postdoctoral Researcher to serve in a leadership role in managing the Translational Neurosurgical Oncology Lab under the direction of Dr. Christina Jackson with the goal of understanding mechanisms of immune evasion by primary malignant brain tumors and skull base tumors to generate novel immune-based therapies. The senior research investigator will play a leading role in developing a research program in the advancement of our research pursuit and will play a crucial role both in all aspects of research products including development, implementation, and data analysis.

Application Deadline: Open Until Filled

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7. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

A Postdoctoral Researcher position is available for a highly motivated applicant in the laboratory of Dr. Fiona Simpkins at the University of Pennsylvania. Our focuses are to understand resistance mechanisms to targeted therapies such as DNA Damage Repair inhibitors (DDRi), to sequence DDRi with Immuno-Oncology (IO) drugs, and to identify biomarkers or response to these agents. We have developed a preclinical drug development program in the Ovarian Cancer Research Center with the goal of moving novel laboratory therapeutic discoveries into the clinic. We have developed >150 patient derived xenografts (PDX) models, patient-derived organoids, and primary tumor cultures from ovarian and endometrial cancers. These PDX models mimic the original tumors, thereby accelerating the translation of preclinical study results into clinical trials for patients.

Application Deadline: Open Until Filled

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8. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

A postdoctoral position is immediately available in the laboratory of Dr. Alessandra Chesi at the University of Pennsylvania with a focus on discovering and functionally characterizing novel genes for Alzheimer’s, Parkinson’s and other neurodegenerative diseases in human brain relevant cell types. Dr. Chesi has a long-standing interest in genomics and neurodegenerative diseases; she has developed Capture C based approaches to map GWAS signals to their effector genes (see some examples in linked publications) and is applying them to brain-related disorders. Main areas of research in our lab are 3D genomics and epigenomics techniques (such as Hi-C, ATAC-seq, ChIP-seq and RNA-seq), CRISPR/Cas9 editing, pooled CRISPRi/a screens with scRNA-seq readout, plus development of iPSC-based models for neurodegenerative and neurodevelopmental diseases (2D neuronal/glial differentiation, co-cultures, 3D brain organoids).

Application Deadline: Open Until Filled

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9. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Wilson laboratory in the Division of Diagnostic Innovation in the Department of Pathology and Laboratory Medicine at Penn is hiring a postdoctoral fellow to work on an established project focused on single cell and spatial analysis of human diabetic kidney disease. This position involves both dry lab and wet lab responsibilities and will consider applicants with experience in either area. The fellow will conduct single cell analysis of human donor specimens from patients with diabetic kidney disease under the supervision of Dr. Wilson. We have already sequenced a large number of single cell libraries in collaboration with Novo Nordisk and preprocessed our dataset for downstream analysis. We are looking for a motivated individual who can work together with our research team to complete any necessary validation studies and move this project to publication. Prior coding experience is not required and the position can be tailored to the applicant skillset.

Application Deadline: Open Until Filled

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10. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

A postdoctoral researcher position is available in the Department of Psychiatry, University of Pennsylvania. The selected applicant will work under the direct supervision of Dr. Rachel Kember, a computational geneticist with expertise in biomedical informatics and psychiatric disorders. The postdoc will also have the opportunity to work with collaborators both at Penn and other institutions on multiple studies involving large-scale datasets. Current projects in the lab focus on understanding the genetic underpinnings of psychiatric and substance use disorders using genetic and phenotypic data from electronic health records with linked biobanks.

Datasets include the Million Veteran Program, a large dataset of over 850,000 veterans with genetic data currently available for 650,000 individuals; the Penn Medicine Biobank, which includes 190,000 patients, 45,000 with genetic data; and the Yale-Penn study, which includes 12,000 individuals with an in-depth substance use and psychiatric assessment. Dr. Kember is co-chair of the PsycheMERGE Diversity Initiative, a collaboration across multiple biobanks formed to address inequity in psychiatric genetics research.

Application Deadline: Open Until Filled

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11. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Applications will be reviewed as they arrive, starting immediately, and will be accepted until the position is filled. For full consideration, we recommend that you apply early. The Penn Computer Assisted Surgery and Outcomes (PCASO) Laboratory within Penn Surgery and the General Robotics, Automation, Sensing and Perception (GRASP) Laboratory at the University of Pennsylvania invites applications for a full-time postdoc opening.

This postdoc will conduct research to develop the next generation of surgical data science algorithms including context awareness, scene understanding, workflow analysis, sim2real transfer, performance assessment, and lifelong learning. The postdoc will also collaborate with other researchers to apply these algorithms to robotic surgery, laparoscopy, flexible endoscopy, and trauma surgery.

Application Deadline: Open Until Filled

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12. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

A one year post doctoral fellowship is available immediately with the option to extend an additional 1-3 years, to investigate the role of the extracellular matrix protein type III collagen (Col3) in modulation of the breast cancer microenvironment. Using a combination of in vitro and mouse models, we have initiated multiple lines of investigation that will provide insight into how Col3 inhibits formation of a tumor-permissive microenvironment. This work also capitalizes on our studies using spontaneous naturally occurring large animal models of mammary tumors. Future work will characterize drivers of tumor-permissive and suppressive collagen signatures and investigate the use of a novel tissue engineering strategy to control tumor growth and metastasis following tumor resection to improve clinical outcome in veterinary and human breast cancer patients.

Application Deadline: Open Until Filled

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13. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Laboratory for Imaging Physics, Analysis, and Clinical translation (IMPACT) is seeking highly motivated individuals to join a number of NIH-funded projects. The IMPACT Lab is directed by Dr. Grace J. Gang and is located in the Department Radiology at the University of Pennsylvania. Our lab is dedicated to developing novel imaging technologies guided by a rigorous understanding of imaging science. Projects in the lab contain a mix of theoretical image chain modeling, benchtop experimentation, and technology integration on clinical imaging system.

Application Deadline: Open Until Filled

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14. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

A postdoctoral position in cellular therapies for solid cancer is available immediately. The postdoc will investigate novel cellular therapies using gamma delta CAR-T cells for solid tumors using state-of-the-art technologies at the University of Pennsylvania. Training will be provided.

Application Deadline: Open Until Filled

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15. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Applications are invited for a postdoctoral position in the laboratory of Dr. Daniel J. Rader at the Perelman School of Medicine (PSOM) of the University of Pennsylvania. This position offers an opportunity to work in a highly collaborative, multidisciplinary research environment focusing on the human genetics of cardiometabolic traits and diseases, the elucidation of novel molecular and physiological mechanisms underlying these phenotypes, and new approaches to therapeutic interventions based on this knowledge. Approaches to this work may include computational genomics, cell-based and/or mouse model systems, protein structure-function relationships, characterizing the functional effects of naturally-occurring coding variants, and human-based mechanistic studies.

Application Deadline: Open Until Filled

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16. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Katona Lab invites applications for a post-doctoral position in the Gastrointestinal Cancer Genetics Program, which is part of the Division of Gastroenterology within the Perelman School of Medicine at the University of Pennsylvania. The Katona Lab is an exciting, highly collaborative, and interdisciplinary research program focused on gastrointestinal cancer and hereditary gastrointestinal cancer predisposition syndromes. Ongoing research activities in our group uniquely span the spectrum of basic science, translation studies, and clinical studies, and involve active collaborations across the Perelman School of Medicine, Abramson Cancer Center, the University of Pennsylvania, and external institutions.

Application Deadline: Open Until Filled

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17. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

A Postdoctoral Researcher position is available in the laboratory of Dr. Jianxin You at the University of Pennsylvania Perelman School of Medicine. The laboratory investigates how the molecular interplay between oncogenic viruses and their host cells leads to cancer (Cell 117:349-360, Cell Host Microbe 19:775-87). We are also developing nanotechnology-based immunotherapy for eliciting antiviral and antitumor immunity against human cancers induced by tumor viruses (Proc Natl Acad Sci U S A. 2020;117:13730-13739).

Application Deadline: Open Until Filled

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18. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Qualified candidates will have demonstrated expertise as in one or more of the following disciplines: cancer biology, cancer metabolism, or chromatin biology. Expertise must be demonstrated through acquisition of a Ph.D. in one of these fields and through the publication (or impending publication) of peer reviewed manuscripts in reputable journals. Candidates should have a strong background in mouse modeling and molecular genetics. Foundational skills in computational genomic analysis is highly desired.

Application Deadline: Open Until Filled

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19. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Feldser Lab is looking for a postdoc to study the cell and molecular requirements for PKC signaling during Kras-mediated tumor initiation. The lab has received NIH funding for a 5 year project to begin immediately. The applicant should have demonstrated expertise in mouse modeling and tissue analysis including microscopy and immune staining techniques. Experience with flow cytometry and cell culture is required. The fellow will be expected to provide mentorship to technicians and students as needed.

Application Deadline: Open Until Filled

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20. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Bowman Laboratory is seeking to fill a postdoctoral fellow position to study clonal evolution in leukemia. Applicants with a recent PhD or MD/PhD with experience in animal modeling of disease or computational modeling of system dynamics are invited to apply. Interested applicants should forward their cover letter and CV to: robert.bowman@pennmedicine.upenn.edu

Application Deadline: Open Until Filled

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21. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Two postdoctoral researcher positions are available in the laboratory of Dr. Xiaolu Yang at the Perelman School of Medicine at the University of Pennsylvania. The Yang lab studies cancer and neurodegenerative diseases. Our current projects focus on two broad areas:

(1) The tumor suppressor p53, metabolism, and autophagy. We are interested in the regulation and functions of the preeminent tumor suppressor p53. Our results have revealed a role for p53 in modulating metabolic pathways that are critical for biosynthesis and redox balance. We are investigating the function of p53 as both a sentinel and a regulator for metabolic activities. We are also identifying and characterizing metabolic alterations that drive tumor initiation and progression. A recent extension of this research area is to define the role of metabolism and autophagy in stem cells, including embryonic stem cells and cancer stem cells.

(2) Protein quality control, aging, and neurodegeneration. Our lab recently identified two protein quality control (PQC) systems, which consist of tripartite motif (TRIM) proteins and poly-Asp/Glu (polyD/E) proteins, respectively. Unlike canonical PQC systems, these new systems are independent of ATP and are unique for animals (the TRIM system) or eukaryotes (the polyD/E system). Both systems are multifunctional and highly effective. We are investigating their mechanisms of action; their roles in aging and neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis; and their utility in treating these diseases.

Application Deadline: Open Until Filled

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The post 21 Postdoctoral Fellowships at University of Pennsylvania, Pennsylvania, USA appeared first on FellowshipBard.

1. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Seeking a talented and highly motivated postdoctoral fellow to collaborate on research aimed at reducing the burden of breast cancer, particularly for racial/ethnic minorities, through precision prevention approaches. The postdoctoral fellow will work under the direct supervision of Dr. Anne Marie McCarthy, a cancer epidemiologist at the University of Pennsylvania Perelman School of Medicine in the Department of Epidemiology, Biostatistics, and Informatics. Projects will cover topic areas including breast cancer risk prediction, integration of genetics into breast cancer prevention, evaluation of novel imaging biomarkers of breast cancer risk, personalized screening, and racial disparities in breast cancer. Flexible start date.

Application Deadline: Open Until Filled

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2. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Conn Lab is looking for 1-2 postdocs focused on post-transcriptional gene regulation and the roles of RNA-binding proteins, RNA modifications, and signaling that are rewired during cancer progression. One project is focused on identifying regulators of selective translation and spatial RNA interactions in the cell during drug resistance in prostate cancer (more mechanism to move into translational research later). The other project is looking at adaptive stress responses in pancreatic tumors and will require mouse modeling, tissue analysis, and treatments in vivo. The lab has received two awards, over 3 years of DoD funding for project one and has independent funds for project two.

Application Deadline: Open Until Filled

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3. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Postdoctoral Researcher will be co-mentored by three PIs: Edward (Ted) Brodkin, MD (Co-Director of ASPE); Maja Bucan, PhD (Co-Director of ASPE); and Laura Almasy, PhD (co-Investigator, ASPE). The Brodkin lab spearheads ASPE’s recruitment, enrollment, and phenotyping efforts, and Dr. Brodkin has expertise in the human phenotypes associated with autism spectrum disorder (ASD), quantitative phenotypes for genomic studies, translational biology, and treatment development. The Bucan lab focuses on delineating the genetic basis of autism-relevant traits and genotype-phenotype relationships in the ASPE cohort, and Dr. Bucan brings to ASPE an expertise in genomics and complex trait analysis, family-based studies of human disease, and bioinformatics.

Application Deadline: Open Until Filled

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4. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The focus of our lab’s research is at the intersection of immunology, metabolism, and brain tumor biology. The primary goal of our translational research is to understand mechanisms of immune evasion by primary malignant brain tumors and skull base tumors to generate novel immune-based therapies. We utilize a combination of high-dimensional single cell immune and genomic profiling, metabolomics, and advanced tumor organoid and mouse models, to 1) understand the role of myeloid derived suppressor cells in promoting tumor growth and T cell dysfunction, 2) elucidate the mechanisms of tumor-specific T cell exhaustion and clonal lineage of dysfunction T cells, and 3) understand how metabolic networks control immune cell function within the tumor microenvironment.

Application Deadline: Open Until Filled

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5. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

A Postdoctoral Researcher position is available for a highly motivated applicant in the laboratory of Dr. Fiona Simpkins at the University of Pennsylvania. Our focuses are to understand resistance mechanisms to targeted therapies such as DNA Damage Repair inhibitors (DDRi), to sequence DDRi with Immuno-Oncology (IO) drugs, and to identify biomarkers or response to these agents. We have developed a preclinical drug development program in the Ovarian Cancer Research Center with the goal of moving novel laboratory therapeutic discoveries into the clinic. We have developed >150 patient derived xenografts (PDX) models, patient-derived organoids, and primary tumor cultures from ovarian and endometrial cancers. These PDX models mimic the original tumors, thereby accelerating the translation of preclinical study results into clinical trials for patients. Also, we are “humanizing” our models by autologous tumor infiltrating lymphocyte (TIL) and macrophage (TAM) transfer, creating an autologous in vivo model system.

Application Deadline: Open Until Filled

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6. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

A postdoctoral position is immediately available in the laboratory of Dr. Alessandra Chesi at the University of Pennsylvania with a focus on discovering and functionally characterizing novel genes for Alzheimer’s, Parkinson’s and other neurodegenerative diseases in human brain relevant cell types. Dr. Chesi has a long-standing interest in genomics and neurodegenerative diseases; she has developed Capture C based approaches to map GWAS signals to their effector genes (see some examples in linked publications) and is applying them to brain-related disorders.

Application Deadline: Open Until Filled

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7. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Wilson laboratory in the Division of Diagnostic Innovation in the Department of Pathology and Laboratory Medicine at Penn is hiring a postdoctoral fellow to work on an established project focused on single cell and spatial analysis of human diabetic kidney disease. This position involves both dry lab and wet lab responsibilities and will consider applicants with experience in either area. The fellow will conduct single cell analysis of human donor specimens from patients with diabetic kidney disease under the supervision of Dr. Wilson. We have already sequenced a large number of single cell libraries in collaboration with Novo Nordisk and preprocessed our dataset for downstream analysis. We are looking for a motivated individual who can work together with our research team to complete any necessary validation studies and move this project to publication. Prior coding experience is not required and the position can be tailored to the applicant skillset. Applicants with bioinformatics experience may be interested in single cell or spatial analysis techniques whereas applicants with molecular biology experience could focus on assay development and cell culture models of diabetic kidney injury.

Application Deadline: Open Until Filled

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8. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Postdoctoral positions are available in the laboratory of Marcelo Kazanietz at the Perelman School of Medicine, University of Pennsylvania, Philadelphia to study basic and translational aspects of cancer signaling, with particular focus in lung and prostate cancer. Requirements: We are looking for highly motivated postdoctoral fellows with demonstrated ability to lead a research project and work independently. Interested candidates should have a PhD and/or MD degree, preferentially no more than 2 years postdoctoral experience, and strong background in cellular and molecular biology. Expertise in cellular and animal models of cancer as well as an excellent publication record in cancer signaling is preferred.

Application Deadline: Open Until Filled

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9. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The position will report to Dr. Daniel Hashimoto with additional collaboration and mentorship from Drs. Kostas Daniilidis and Eric Eaton of Penn Engineering. The compensation package includes a competitive salary, health benefits, career mentoring, and conference travel support. The position offers opportunities to work with medical device industry collaborators and to be involved in leadership of national and international collaborative research projects through the Global Surgical AI Collaborative. The post doc will have access to resources through both the School of Medicine and the GRASP Lab at Penn Engineering.

Application Deadline: Open Until Filled

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10. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

A one year POSTDOCTORAL POSITION (with the option to extend an additional 1-3 years) is available to continue and expand studies into the mechanisms by which select virus-host interactions regulate entry and/or egress of emerging RNA viruses including Ebola, Marburg, and Lassa fever (as described in Liang et al., 2021 J. Virol.; 2022 J. Virol.; 2023 PNAS; and Han et al., 2020 PLOS Pathog.; 2020 J. Biol. Chem.; 2021 Antimicrob. Agents Chemotherapy.

Application Deadline: Open Until Filled

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11. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Laboratory for Imaging Physics, Analysis, and Clinical translation (IMPACT) is seeking highly motivated individuals to join a number of NIH-funded projects. The IMPACT Lab is directed by Dr. Grace J. Gang and is located in the Department Radiology at the University of Pennsylvania. Our lab is dedicated to developing novel imaging technologies guided by a rigorous understanding of imaging science. Projects in the lab contain a mix of theoretical image chain modeling, benchtop experimentation, and technology integration on clinical imaging system.
Multiple positions open for full-time research scientists or postdoctoral researchers. We are seeking candidates for a number of projects including development and evaluation of deep learning image formation algorithms, system design and optimization for spectral imaging, and developing analytical and deep learning strategies for radiomics standardization.

Application Deadline: Open Until Filled

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12. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

A postdoctoral position in cellular therapies for solid cancer is available immediately. The postdoc will investigate novel cellular therapies using gamma delta CAR-T cells for solid tumors using state-of-the-art technologies at the University of Pennsylvania. Training will be provided.

Application Deadline: Open Until Filled

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13. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Applications are invited for a postdoctoral position in the laboratory of Dr. Daniel J. Rader at the Perelman School of Medicine (PSOM) of the University of Pennsylvania. This position offers an opportunity to work in a highly collaborative, multidisciplinary research environment focusing on the human genetics of cardiometabolic traits and diseases, the elucidation of novel molecular and physiological mechanisms underlying these phenotypes, and new approaches to therapeutic interventions based on this knowledge. Approaches to this work may include computational genomics, cell-based and/or mouse model systems, protein structure-function relationships, characterizing the functional effects of naturally-occurring coding variants, and human-based mechanistic studies.

Application Deadline: Open Until Filled

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14. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

A postdoctoral Researcher position is available in the laboratory of Dr. Jianxin You at the University of Pennsylvania Perelman School of Medicine. The laboratory investigates how the molecular interplay between oncogenic viruses and their host cells leads to cancer (Cell 117:349-360, Cell Host Microbe 19:775-87). We are also developing nanotechnology-based immunotherapy for eliciting antiviral and antitumor immunity (Proc Natl Acad Sci U S A. 2020;117:13730-13739)

Application Deadline: Open Until Filled

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15. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Two postdoctoral researcher positions are available in the laboratory of Dr. Xiaolu Yang at the Perelman School of Medicine at the University of Pennsylvania. The Yang lab studies cancer and neurodegenerative diseases. Our current projects focus on two broad areas:
(1) The tumor suppressor p53, metabolism, and autophagy. We are interested in the regulation and functions of the preeminent tumor suppressor p53. Our results have revealed a role for p53 in modulating metabolic pathways that are critical for biosynthesis and redox balance. We are investigating the function of p53 as both a sentinel and a regulator for metabolic activities. We are also identifying and characterizing metabolic alterations that drive tumor initiation and progression. A recent extension of this research area is to define the role of metabolism and autophagy in stem cells, including embryonic stem cells and cancer stem cells.
(2) Protein quality control, aging, and neurodegeneration. Our lab recently identified two protein quality control (PQC) systems, which consist of tripartite motif (TRIM) proteins and poly-Asp/Glu (polyD/E) proteins, respectively. Unlike canonical PQC systems, these new systems are independent of ATP and are unique for animals (the TRIM system) or eukaryotes (the polyD/E system). Both systems are multifunctional and highly effective. We are investigating their mechanisms of action; their roles in aging and neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis; and their utility in treating these diseases.

Application Deadline: Open Until Filled

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16. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Feldser Lab is looking for a postdoc to study the cell and molecular requirements for PKC signaling during Kras-mediated tumor initiation. The lab has received NIH funding for a 5 year project to begin immediately.

Application Deadline: Open Until Filled

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17. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Bowman Laboratory is seeking to fill a postdoctoral fellow position to study clonal evolution in leukemia. Applicants with a recent PhD or MD/PhD with experience in animal modeling of disease or computational modeling of system dynamics are invited to apply.

Application Deadline: Open Until Filled

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1. Postdoctoral Position in Spatial Omics

Summary of Postdoctoral Fellowship:

We are looking for an exceptionally creative and self-motivated postdoctoral fellow to join us in developing new technologies for spatial omics profiling at the cellular level. The successful candidate will collaborate with internal and external groups to solve challenging biological problems. The work will be multi-disciplinary, combining microchip, microscopy, genomics, and computational analysis to profile genome, epigenome, transcriptome, and proteome within the spatial context of tissues and cells. These novel technologies will greatly improve our ability to study tissue complexity and reveal the salient features of tissue architecture in physiology and disease.

Application Deadline: Open Until Filled

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2. Multiple Postdoctoral Position in Cell and Developmental Biology

Summary of Postdoctoral Fellowship:

Multiple NIH-funded postdoctoral positions are available in the laboratory of Rajan Jain in the Departments of Medicine and Cell & Developmental Biology at the Perelman School of Medicine at the University of Pennsylvania. Our laboratory uses genetic, biochemical, imaging and genomic approaches to decipher how nuclear architecture governs cell fate decisions. Our laboratory routinely utilizes multiple mouse models and ESC/iPSC differentiation strategies. We are part of a vibrant community at Penn, including the Epigenetics Institute, Institute for Regenerative Medicine, Cardiovascular Institute and Center for Engineering and Mechanobiology. We are a highly collaborative group that routinely works across disciplines.

Application Deadline: Open Until Filled

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3. 02 Postdoctoral Position in Genetic Regulation of Skeletal Cells

Summary of Postdoctoral Fellowship:

Two postdoctoral fellow positions are available in the Lefebvre laboratory in the Translational Research Program in Pediatric Orthopaedics at the Children’s Hospital of Philadelphia (CHOP) Abramson Research Institute. The fellows will elucidate specific genetic and epigenetic mechanisms whereby SOX and other transcription factors interact with one another and with growth factor signaling pathways to govern the commitment of mesenchymal progenitor/stem cells to skeletal lineages and the multi-step programs of osteoblast and chondrocyte differentiation.

The fellows will use cutting-edge approaches in vivo and in vitro, including mouse models and high-throughput ‘omics’ approaches. Successful accomplishment of this research is anticipated to deepen fundamental scientific knowledge, increase understanding of mechanisms underlying skeleton malformation and degenerative diseases, and help the fellows launch promising careers as independent research investigators.

Application Deadline: Open Until Filled

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4. Postdoctoral Position in human tumor immunology

Summary of Postdoctoral Fellowship:

We are seeking a highly devoted and enthusiastic PhD or MD/PhD scientist to join our group as a postdoctoral research fellow. He/She will be involved in investigating the role of the inflammatory myeloid cells in the tumor microenvironment and the cellular and molecular mechanisms by which tumor modulates their immune functions in cancer patients. Specifically, the researcher will investigate the role of the tumor-infiltrating macrophages and neutrophils in the regulation of tumor-specific T cell and NK cell responses in lung cancer patients. Also, He/She will investigate the ability of tumor-associated neutrophils and macrophages to regulate anti-tumor antibody-triggered immune responses.

Application Deadline: Open Until Filled

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5. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Heller Lab studies the mechanisms by which epigenetic remodeling regulates gene function, in the context of neuropsychiatric diseases such as addiction and depression. To approach this problem, we directly manipulate histone and DNA modifications at specific genes in vivo, using viral delivery of novel epigenetic editing tools, such as CRISPR/dCas9-fusion proteins. This ‘bottom-up’ approach allows direct elucidation of the causal relevance of epigenetic remodeling in the brain. Because addiction and depression persist long after cessation of the harmful experience, epigenetic remodeling is an attractive underlying mechanism and presents an intriguing target for therapeutic intervention.

Application Deadline: Open Until Filled

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6. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

This position at the Children’s Hospital of Philadelphia (CHOP) will focus on defining translational physiology at birth and associated clinical outcomes for newborns with congenital anomalies. Applicants may include clinical investigators with training in pediatrics or neonatology or early-stage postdoctoral fellows interested in reproductive, perinatal, and pediatric epidemiology. Applicants will have a unique opportunity to conduct research in the world-first dedicated birthplace for babies with congenital anomalies, the Garbose Family Special Delivery Unit (SDU). Over 500 babies are born in the SDU yearly, making CHOP the largest global delivery centers for newborns with conditions including congenital heart disease, congenital diaphragmatic hernia, pulmonary hypoplasia, abdominal wall defects, and neural tube defects.

Application Deadline: Open Until Filled

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7. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Romano Lab at the University of Pennsylvania is recruiting a postdoctoral researcher to develop and apply new methods in computational toxicology using artificial intelligence and techniques from biomedical informatics. We develop knowledge graphs to computationally predict and explain the downstream clinical effects that arise following exposure to environmental toxicants. This postdoc position will involve extending these knowledge graphs to new biomedical data types, and applying graph machine learning (Graph ML) to detect novel adverse outcome pathways. They will also have the opportunity to interact with real-world observational datasets (e.g., Penn’s Electronic Data Warehouse and Biobank resources) to validate the Graph ML predictions.

Application Deadline: Open Until Filled

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8. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

A position is available in the Mitchell Laboratory of Neurodegeneration for a postdoctoral student to investigate the relationship between lysosomal pathology and neurodegeneration. The research is translational and will focus on identifying pharmacologic and nanoparticle approaches to restore lysosomal function using cell physiology and molecular biology techniques. Assays to detect defects in lysosomal health will be applied to neurons, microglia and/or astrocytes and used to identify successful treatments. The project will also develop novel reporters to indicate lysosomal function. The successful candidate must be driven, adept with current molecular biology tools and be able to write scientific papers.

Application Deadline: Open Until Filled

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9. 02 Postdoctoral Position in epigenetic mechanisms of neural developmental and disorders

Summary of Postdoctoral Fellowship:

The Akizu lab seeks candidates for a postdoctoral position in epigenetic mechanisms of neural developmental and disorders. The applicant must have a recent PhD in relevant fields, research experience in epigenomic (i.e. ChIPseq, Cut&Run, ATACseq, Hi-C…) OR human pluripotent stem cell culturing and organoid differentiation methods and at least one first author publication in an impactful scientific journal. The ideal candidate must be highly motivated and creative with strong ability to design and carry out experiments with a high level of independence. The successful candidate will work full time in one of our recently funded projects while also collaborating with other lab members and investigators in our institution. 

Application Deadline: Open Until Filled

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10. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

A Postdoctoral Researcher position is immediately available for a highly motivated applicant in the laboratory of Dr. Daniel Pryma in the Department of Radiology in close collaboration with Dr. Sarah Gitto in the Department of Pathology and Laboratory Medicine at the Perelman School of Medicine, University of Pennsylvania. This is a full-time position with funding for up to five years.

The research focuses on preclinical optimization of a novel poly (ADP-ribose) polymerase (PARP) targeted radiopharmaceutical therapy to treat cancer, including drug-resistant ovarian cancer. A PET imaging companion diagnostic will be developed in parallel as a prognostic biomarker as well as for image-guided treatment planning. Studies will utilize preclinical cell line and murine models to evaluate this highly translational theranostic approach. Candidates will work in a highly interdisciplinary team of clinical and basic science researchers with expertise in radiology, oncology, biology, and immunology.

Application Deadline: Open Until Filled

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11. 02 Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Nathanson laboratory invites applications for Post-Doctoral positions at the Perelman School of Medicine, University of Pennsylvania. We focus on cutting-edge translational research in cancer genetics, both in the inherited and somatic genetics of cancer (example publications include Hu et al., NEJM 2021; Maxwell et al., JCO Pres Onc, 2020; Kraya et al., Clin Cancer Res 2019). Expertise and interest in both wet bench studies and bioinformatics is preferred, however applicants with only expertise in bioinformatics would be welcome. The laboratory is highly collaborative and investigates several cancers, among which are hereditary breast cancer (due to BRCA1/2 and non-BRCA1/2 mutations), melanoma, testicular germ cell tumors, and neuroendocrine tumors. Applications for postdoctoral positions are invited across all areas of research, all of which are funded by multiple NIH grants and foundation funding.

Application Deadline: Open Until Filled

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12. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

A postdoctoral position in human immunology and/or bioinformatics is available immediately in the laboratory of Dr. Michael R. Betts at the University of Pennsylvania Perelman School of Medicine. Our group studies human immunology in the context of various human diseases including HIV, SIV, type I diabetes, and others. With our unique access to human samples, we are using high-parameter flow cytometry and next-generation techniques at single-cell resolution to parse through cellular heterogeneity and understand the roles of various rare cell populations in their contribution to human disease.

Application Deadline: Open Until Filled

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1. Two Postdoctoral Position in cancer and neurodegeneration

Summary of Postdoctoral Fellowship:

Two postdoctoral researcher positions are available in the laboratory of Dr. Xiaolu Yang at the Perelman School of Medicine at the University of Pennsylvania. The Yang lab is interested in molecular and cellular mechanisms that protect against cancer and neurodegeneration. The current projects focus on two broad areas: The tumor suppressor p53, metabolism, and autophagy. We are interested in the regulation and functions of the preeminent tumor suppressor p53. Our results have revealed an important role for p53 in modulating metabolic pathways that are critical for biosynthesis and redox balance. We are investigating the function of p53 as both a sentinel and a regulator for metabolic activities. 

Application Deadline: Open Until Filled

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2. Postdoctoral Position in Cardiovascular Research

Summary of Postdoctoral Fellowship:

A postdoctoral fellow position is available in the Cardiovascular Institute of the University of Pennsylvania Perelman School of Medicine to perform basic-translational research focused on the coronary microvasculature. Coronary Microvascular Disease (CMVD) accounts for 30-50% of ischemic heart disease yet has been understudied in the past. We have developed novel methods to image the coronary microcirculation and uncover novel mechanisms of CMVD. This position focuses on using genomics, mouse models, novel mouse imaging, and cell and molecular studies on gene regulation to understand the pathogenesis of CMVD and develop novel therapeutic approaches.

Application Deadline: Open Until Filled

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3. Postdoctoral Position in metastatic microenvironment

Summary of Postdoctoral Fellowship:

A POSTDOCTORAL POSITION to continue and expand studies into the mechanisms of immuno-suppression in the primary tumor and metastatic microenvironment and importance of these mechanisms in cancer therapies (as described in Cancer Cell 2017 and 2019, Cell Metab 2022, Nat Cancer 2020 and 2022 and J Clin Invest 2021). Qualifications: Highly motivated applicants with a doctoral degree (PhD or MD/analogue) and strong interests in the areas of tumorigenesis, immunity and inflammation and experience in molecular/cell biology and/or pathology and genetics of mouse disease models are encouraged to apply.

Application Deadline: Open Until Filled

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4. 2+ Postdoctoral Position in imaging and genomics

Summary of Postdoctoral Fellowship:

Multiple NIH-funded postdoctoral positions are available in the laboratory of Rajan Jain in the Departments of Medicine and Cell & Developmental Biology at the Perelman School of Medicine at the University of Pennsylvania. Our laboratory uses genetic, biochemical, imaging and genomic approaches to decipher how nuclear architecture governs cell fate decisions. Our laboratory routinely utilizes multiple mouse models and ESC/iPSC differentiation strategies. We are part of a vibrant community at Penn, including the Epigenetics Institute, Institute for Regenerative Medicine, Cardiovascular Institute and Center for Engineering and Mechanobiology. We are a highly collaborative group that routinely works across disciplines.

Application Deadline: Open Until Filled

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5. Postdoctoral Position in Human Genome Editing

Summary of Postdoctoral Fellowship:

A postdoctoral position for a computational biologist is available in the interdisciplinary Human Genome Editing and Translational and Correlative Sciences Laboratories. We are part of the Department of Microbiology within the University of Pennsylvania Perelman School of Medicine. We are also a member of the Center for Cellular Immunotherapies and Abramson Cancer Center. Our group is multidisciplinary, integrating computational and experimental approaches to develop a single to collective cell understanding of gene regulation in engineered immune cells and their interaction with tumor cells.

Application Deadline: Open Until Filled

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6. Postdoctoral Position in human tumor immunology

Summary of Postdoctoral Fellowship:

We are seeking a highly devoted and enthusiastic PhD or MD/PhD scientist to join our group as a postdoctoral research fellow. He/She will be involved in investigating the role of the inflammatory myeloid cells in the tumor microenvironment and the cellular and molecular mechanisms by which tumor modulates their immune functions in cancer patients. Specifically, the researcher will investigate the role of the tumor-infiltrating macrophages and neutrophils in the regulation of tumor-specific T cell and NK cell responses in lung cancer patients. Also, He/She will investigate the ability of tumor-associated neutrophils and macrophages to regulate anti-tumor antibody-triggered immune responses.

Application Deadline: Open Until Filled

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7. Postdoctoral Position in Duchenne’s Muscular Dystrophy Therapy

Summary of Postdoctoral Fellowship:

A position is available in the Khurana laboratory at The Department of Physiology & Pennsylvania Muscle Institute to conduct basic and translational research on muscular dystrophy; specifically to develop Utrophin Gene Editing for Duchenne’s Muscular Dystrophy Therapy. We use a combination of physiological, molecular, biochemical and genetic approaches to understand the basic biology of muscle, and develop therapies for the muscular dystrophies.

Application Deadline: Open Until Filled

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8. Postdoctoral Position in Neuroepigenetics

Summary of Postdoctoral Fellowship:

The Heller Lab studies the mechanisms by which epigenetic remodeling regulates gene function, in the context of neuropsychiatric diseases such as addiction and depression. To approach this problem, we directly manipulate histone and DNA modifications at specific genes in vivo, using viral delivery of novel epigenetic editing tools, such as CRISPR/dCas9-fusion proteins. This ‘bottom-up’ approach allows direct elucidation of the causal relevance of epigenetic remodeling in the brain. Because addiction and depression persist long after cessation of the harmful experience, epigenetic remodeling is an attractive underlying mechanism and presents an intriguing target for therapeutic intervention.

Application Deadline: Open Until Filled

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9. Postdoctoral Position in Duchenne Muscular Dystrophy

Summary of Postdoctoral Fellowship:

A muscle and cardiovascular biology postdoctoral fellowship position is immediately available in the laboratory of Hansell Stedman, MD, FACS, Department of Surgery, Penn Cardiovascular Institute and Pennsylvania Muscle Institute. The main goals are to improve the understanding of transcriptional control in muscle and to use the novel insights in the development of safe and effective gene therapy for dystrophin-deficient cardiomyopathy and respiratory failure, with the ultimate goal of clinical translation for Duchenne Muscular Dystrophy. We are using complementary approaches to the rational design of next generation vectors to address the shortcomings of candidate therapies tested in recent clinical trials.

Application Deadline: Open Until Filled

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10. Postdoctoral Position in Neonatal Resuscitation

Summary of Postdoctoral Fellowship:

The Neonatal Resuscitation Research Program is accepting postdoctoral applications for positions starting July 1, 2023. This position at the Children’s Hospital of Philadelphia (CHOP) will focus on defining translational physiology at birth and associated clinical outcomes for newborns with congenital anomalies. Applicants may include clinical investigators with training in pediatrics or neonatology or early-stage postdoctoral fellows interested in reproductive, perinatal, and pediatric epidemiology.

Application Deadline: Open Until Filled

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11. Postdoctoral Position in DNA replication regulation in hematopoietic stem cells

Summary of Postdoctoral Fellowship:

A postdoctoral fellow position is available at the University of Pennsylvania School of Medicine and the Children’s Hospital of Philadelphia, to perform state-of-the-art CRISPR/Cas9 screens to identify novel therapeutic targets for treating hematopoietic stem cell diseases. Hematopoietic stem cells give rise to all circulating blood cells throughout life. Maintenance of stem cell self-renewal, proliferation and differentiation is regulated by complex signaling pathways. Aberrant regulation leads to bone marrow failure or leukemia. Genome integrity plays a critical role in the prevention of leukemia, ageing, and blood development.

Application Deadline: Open Until Filled

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12. Postdoctoral Position in in neuroethics

Summary of Postdoctoral Fellowship:

The Wexler Lab at the Department of Medical Ethics & Health Policy at the Perelman School of Medicine at the University of Pennsylvania is seeking a full-time postdoctoral fellow in neuroethics. This is a 12-month position with a desired start date of summer 2023, though earlier/later starts may be considered. There is a possibility for renewal contingent upon funding. The fellow will work on a project that utilizes sociological methods to study the ethical, legal, and social implications of neurotechnology.

Application Deadline: Open Until Filled

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13. Postdoctoral Position in epigenetic mechanisms of neural developmental and disorders

Summary of Postdoctoral Fellowship:

The Akizu lab seeks candidates for a postdoctoral position in epigenetic mechanisms of neural developmental and disorders. The applicant must have a recent PhD in relevant fields, research experience in epigenomic (i.e. ChIPseq, Cut&Run, ATACseq, Hi-C…) OR human pluripotent stem cell culturing and organoid differentiation methods and at least one first author publication in an impactful scientific journal.

Application Deadline: Open Until Filled

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14. Two Postdoctoral Position in Genetic Regulation of Skeletal Cells

Summary of Postdoctoral Fellowship:

Two postdoctoral fellow positions are available in the Lefebvre laboratory in the Translational Research Program in Pediatric Orthopaedics at the Children’s Hospital of Philadelphia (CHOP) Abramson Research Institute. The fellows will elucidate specific genetic and epigenetic mechanisms whereby SOX and other transcription factors interact with one another and with growth factor signaling pathways to govern the commitment of mesenchymal progenitor/stem cells to skeletal lineages and the multi-step programs of osteoblast and chondrocyte differentiation.

Application Deadline: Open Until Filled

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15. Postdoctoral Position in Bacterial Pathogenesis

Summary of Postdoctoral Fellowship:

A postdoctoral position is available immediately in the Zhu laboratory in the Microbiology Department of the School of Medicine. We are studying pathogen-host-microbiome and antibiotic resistance mechanisms, including Vibrio cholerae and multi-drug resistant enterobacteria.

Application Deadline: Open Until Filled

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16. Postdoctoral Position in human immunology and bioinformatics

Summary of Postdoctoral Fellowship:

A postdoctoral position in human immunology and/or bioinformatics is available immediately in the laboratory of Dr. Michael R. Betts at the University of Pennsylvania Perelman School of Medicine. Our group studies human immunology in the context of various human diseases including HIV, SIV, type I diabetes, and others. With our unique access to human samples, we are using high-parameter flow cytometry and next-generation techniques at single-cell resolution to parse through cellular heterogeneity and understand the roles of various rare cell populations in their contribution to human disease.

Application Deadline: Open Until Filled

More Details

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