1. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Our lab studies host-pathogen interactions with the goal of defining host and bacterial pathways involved in bacterial persistence. Bacterial interactions with the host involve dynamic exchanges where heterogeneity from both sides can lead to many different outcomes. Persistence occurs when the pathogen evades the host immune response and the host is unable to clear the invading pathogen, resulting in stable bacterial colonization. Individuals with persistent infections often do not respond to long-term or repeated appropriate antibiotic treatment and, importantly, serve as reservoirs for the development of antibiotic resistance.

Application Deadline: Open Until Filled

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2. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Projects in the lab span interests related to type 2 inflammation, parasitic infection, chronic lung disease, and autoimmune/autoinflammatory conditions. Applicants are expected to work well with others in a highly collaborative environment making contributions across multiple projects in addition to driving their own research program. Candidates must have experience or a willingness to learn techniques related to both mouse and human immune models. Expertise in molecular biology, flow cytometry, fluorescent microscopy, cell culture, mouse genetics, and bioinformatics is strongly valued. We encourage anyone with a strong work ethic, high resilience, good communication skills, and desire to learn and make an impact with their science should apply. In particular, candidates that bring novel experiences, backgrounds, training and perspectives are highly valued.

Application Deadline: Open Until Filled

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3. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Dr. Hisert is seeking a Postdoctoral Research Fellow to work on a project investigating the interactions of macrophages with various CF airway pathogens, including Pseudomonas aeruginosa and nontuberculous mycobacteria. The project involves isolation of cells from human blood, tissue culture, bacterial culture of BSL2 organisms, and infection of human cells. The project may also involve flow cytometry, immunoblotting, and animal models of disease. Success will require knowledge of innate immunity, microbiology, and host pathogen interactions. A strong background in at least one of these three areas is essential.

Application Deadline: Open Until Filled

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4. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

It is increasingly recognized that maternal environmental exposures and health status impact on fetal and neonatal immune systems, shaping offspring susceptibility to immune-mediated diseases, including allergies and asthma. Childhood asthma positively associates with maternal stress and maternal exposure to air pollutants, and negatively, with maternal exposure to microbes present in the farming environment. Mechanisms how maternal environment and health status affect the offspring immune system and predisposition to asthma are unclear. Dr. Gorska’s lab is focused on addressing these knowledge gaps.

Application Deadline: Open Until Filled

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5. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The successful applicant will join a new project focused on investigating the mechanisms linking mis-expression of the mucin MUC5B in the distal lung and terminal bronchioles to fibroblast accumulation and activation in the context of persistent lung fibrosis. Most of the experimental work will be with a mouse model of lung fibrosis, with translational studies being conducted using primary human lung cells and tissues. The project will require a strong background in mouse breeding, multi-parameter flow cytometry, preparation of tissues and pathophysiologic assessments of lung disease, and basic laboratory skills including cell culture, RNA isolation, Western blotting and fluorescence microscopy. A basic understanding of bioinformatic approaches to analyze big RNA-sequencing data sets is desirable.

Application Deadline: Open Until Filled

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6. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Our lab has discovered and characterized a novel population of resident lung mesenchymal stem cells (MSC) in murine and human systems. Research efforts are focused on understanding how these stem cells regulate tissue homeostasis as well as remodeling at the expense of repair during chronic lung disease. Training on specific techniques used in the laboratory will be provided. General techniques utilized in the lab include: in vivo and in vitro modeling of stem cell fate and function, flow cytometry, cell culture, measuring physiology, confocal & 2-photon microscopy and molecular biology (PCR, Western blots, transfections, etc.)

Application Deadline: Open Until Filled

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7. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Our research focuses on mechanisms of lung injury and repair in the pathogenesis of lung diseases. Our goal is to identify therapeutic targets for diseases caused by exposures to cigarette smoke, vaping, and respiratory viral infections, such as COPD/emphysema, pulmonary hypertension, and ARDS. Our research projects employ complementary approaches including molecular and cellular biology, biochemistry, pulmonary patho-physiological assessment of small animal models of disease, and translational approaches using human cohorts. Postdoctoral fellows in our laboratory are encouraged and mentored to apply for extramural funding and provided with opportunity to teach, write manuscripts, and present data at international conferences.

Application Deadline: Open Until Filled

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8. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Seibold Laboratory is a cutting-edge, NIH funded, laboratory focused on elucidating the pathobiological basis of asthma and other complex lung and allergic diseases. Our goal is to discover pathobiological subgroups of disease (termed disease endotypes) and the genetic, environmental, and immune factors driving their development. We are accomplishing these goals through the integration of genomic endotyping studies of large patient cohorts with in vitro mechanistic studies of human organoid culture models. Ultimately, we will leverage the information gained from our research to develop precision medicine approaches for the diagnosis, management, and treatment of these diseases. 

Application Deadline: Open Until Filled

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9. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Seibold Laboratory is a cutting-edge, NIH funded, laboratory focused on elucidating the pathobiological basis of asthma and other complex lung and allergic diseases. Our goal is to discover pathobiological subgroups of disease (termed disease endotypes) and the genetic, environmental, and immune factors driving their development. We are accomplishing these goals through the integration of genomic endotyping studies of large patient cohorts with in vitro mechanistic studies of human organoid culture models. Ultimately, we will leverage the information gained from our research to develop precision medicine approaches for the diagnosis, management, and treatment of these diseases. The Seibold Laboratory is composed of a multi-disciplinary team of “wet lab” cell, airway, and molecular biologists integrated with “dry lab” computational biologists, bioinformaticians, and statistical geneticists.

Application Deadline: Open Until Filled

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The post 09 Postdoctoral Fellowships at National Jewish Health, Colorado appeared first on FellowshipBard.

1. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

National Jewish Health, a world leader in respiratory research, in Denver, CO invites applications for a post-doctoral position under the mentorship of Dr. Anthony N. Gerber. This position is focused on genetics and genomics of lung disease, with active projects directed at understanding pharmacogenomics and environmental risk in asthma, and the pathogenesis of idiopathic pulmonary fibrosis in relationship to MUC5B regulation. Experimental approaches include deep sequencing based methods, such as PRO-seq, ATAC-seq, ChIP-seq, and MicroC, bioinformatics analysis, and functional genomics. Applicants must have a Ph.D. and exhibit expertise in molecular biology and/or bioinformatics. This highly collaborative position is suitable for scientists planning careers in either industry or academic science, and training opportunities to facilitate career development are available.

Application Deadline: Open Until Filled

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2. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

To perform, on a very independent basis, all phases of experimental investigations and to collaborate with Principal Investigators and senior researchers in the progress of major research projects. To act as technical advisor to laboratory technical, support and auxiliary staff. Essential Duties: Performs, on a very independent basis, all phases of experimental investigations, to include being responsible to the Principal Investigator in the planning, developing, operating, recording, collaborating and reporting of major projects.

Application Deadline: Open Until Filled

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3. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Majka Lab at National Jewish Health and is seeking a Postdoctoral Research Fellow to join their innovative team studying lung stem cell fate and function. Our lab has discovered and characterized a novel population of resident lung mesenchymal stem cells (MSC) in murine and human systems. Research efforts are focused on understanding how these stem cells regulate tissue homeostasis as well as remodeling at the expense of repair during chronic lung disease. Training on specific techniques used in the laboratory will be provided. General techniques utilized in the lab include: in vivo and in vitro modeling of stem cell fate and function, flow cytometry, cell culture, measuring physiology, confocal & 2-photon microscopy and molecular biology (PCR, Western blots, transfections, etc.)

Application Deadline: Open Until Filled

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4. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

We are seeking a Postdoctoral Research Associate to join the laboratory of Irina Petrache, MD, in the Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine at National Jewish Health, in Denver, CO. Our research focuses on mechanisms of lung injury and repair in the pathogenesis of lung diseases. Our goal is to identify therapeutic targets for diseases caused by exposures to cigarette smoke, vaping, and respiratory viral infections, such as COPD/emphysema, pulmonary hypertension, and ARDS. Our research projects employ complementary approaches including molecular and cellular biology, biochemistry, pulmonary patho-physiological assessment of small animal models of disease, and translational approaches using human cohorts. Postdoctoral fellows in our laboratory are encouraged and mentored to apply for extramural funding and provided with opportunity to teach, write manuscripts, and present data at international conferences.

Application Deadline: Open Until Filled

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5. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Seibold Laboratory is a cutting-edge, NIH funded, laboratory focused on elucidating the pathobiological basis of asthma and other complex lung and allergic diseases. Our goal is to discover pathobiological subgroups of disease (termed disease endotypes) and the genetic, environmental, and immune factors driving their development. We are accomplishing these goals through the integration of genomic endotyping studies of large patient cohorts with in vitro mechanistic studies of human organoid culture models. Ultimately, we will leverage the information gained from our research to develop precision medicine approaches for the diagnosis, management, and treatment of these diseases. The Seibold Laboratory is composed of a multi-disciplinary team of “wet lab” cell, airway, and molecular biologists integrated with “dry lab” computational biologists, bioinformaticians, and statistical geneticists.

Application Deadline: Open Until Filled

More Details

6. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Seibold Laboratory is a cutting-edge, NIH funded, laboratory focused on elucidating the pathobiological basis of asthma and other complex lung and allergic diseases. Our goal is to discover pathobiological subgroups of disease (termed disease endotypes) and the genetic, environmental, and immune factors driving their development. We are accomplishing these goals through the integration of genomic endotyping studies of large patient cohorts with in vitro mechanistic studies of human organoid culture models. Ultimately, we will leverage the information gained from our research to develop precision medicine approaches for the diagnosis, management, and treatment of these diseases. The Seibold Laboratory is composed of a multi-disciplinary team of “wet lab” cell, airway, and molecular biologists integrated with “dry lab” computational biologists, bioinformaticians, and statistical geneticists.

Application Deadline: Open Until Filled

More Details

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7. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Numata-Nakamura Lab at National Jewish Health is seeking a highly motivated and skilled Postdoctoral Research Associate to join our team. Our lab is studying innate immunity of the lung, focusing on anti-viral effects of pulmonary surfactant phospholipids against respiratory viruses (e.g., Respiratory syncytial virus (RSV), Influenza A, Rhinovirus and SARS-CoV-2) using primary human airway epithelial cells and immune cells. Techniques used in the lab include, human primary cell cultures maintained in air-liquid interface cultures, fluorescence microscopy, flow cytometry, ELISA, molecular biology (DNA/RNA isolation, PCR), viral replication to make recombinant viruses and in vivo animal models. Training on specific techniques used in the laboratory will be provided. Significant experience with bacterial culture and molecular biology and/or mammalian cells is strongly preferred.

Application Deadline: Open Until Filled

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8. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Dooms laboratory in the Department of Immunology and Genomic Medicine at National Jewish Health, Denver, Colorado is seeking to recruit a highly motivated and skilled Postdoctoral Research Fellow to study the role of T cells in autoimmune diseases. Our laboratory is interested in understanding how T cells become dysregulated and cause autoimmunity. We are specifically investigating how T cell exhaustion, caused by chronic antigen exposure, may play protective or pathogenic roles in autoimmune diseases, and how this mechanism can be exploited for therapeutic intervention. We are currently using samples from Systemic Sclerosis patients and the NOD mouse model of Type 1 Diabetes to answer these questions.

Application Deadline: Open Until Filled

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9. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Penaranda Lab in the Department of Immunology and Genomic Medicine is seeking a Postdoctoral Research Fellow. Our lab studies host-pathogen interactions with the goal of defining host and bacterial pathways involved in bacterial persistence. Bacterial interactions with the host involve dynamic exchanges where heterogeneity from both sides can lead to many different outcomes. Persistence occurs when the pathogen evades the host immune response and the host is unable to clear the invading pathogen, resulting in stable bacterial colonization. Individuals with persistent infections often do not respond to long-term or repeated appropriate antibiotic treatment and, importantly, serve as reservoirs for the development of antibiotic resistance. We do not understand why certain infections progress to persistence while others do not. Moreover, the host pathways that lead to persistence have remained an underexplored area of investigation.

Application Deadline: Open Until Filled

More Details

The post 09 Postdoctoral Fellowships at National Jewish Health, Colorado, USA appeared first on FellowshipBard.

1. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Seibold Laboratory is a cutting-edge, NIH funded, laboratory focused on elucidating the pathobiological basis of asthma and other complex lung and allergic diseases. Our goal is to discover pathobiological subgroups of disease (termed disease endotypes) and the genetic, environmental, and immune factors driving their development.

We are accomplishing these goals through the integration of genomic endotyping studies of large patient cohorts with in vitro mechanistic studies of human organoid culture models. Ultimately, we will leverage the information gained from our research to develop precision medicine approaches for the diagnosis, management, and treatment of these diseases. The Seibold Laboratory is composed of a multi-disciplinary team of “wet lab” cell, airway, and molecular biologists integrated with “dry lab” computational biologists, bioinformaticians, and statistical geneticists.

Application Deadline: Open Until Filled

More Details

2. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Seibold Laboratory is a cutting-edge, NIH funded, laboratory focused on elucidating the pathobiological basis of asthma and other complex lung and allergic diseases. Our goal is to discover pathobiological subgroups of disease (termed disease endotypes) and the genetic, environmental, and immune factors driving their development. We are accomplishing these goals through the integration of genomic endotyping studies of large patient cohorts with in vitro mechanistic studies of human organoid culture models.

Ultimately, we will leverage the information gained from our research to develop precision medicine approaches for the diagnosis, management, and treatment of these diseases. The Seibold Laboratory is composed of a multi-disciplinary team of “wet lab” cell, airway, and molecular biologists integrated with “dry lab” computational biologists, bioinformaticians, and statistical geneticists.

Application Deadline: Open Until Filled

More Details

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3. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Numata-Nakamura Lab at National Jewish Health is seeking a highly motivated and skilled Postdoctoral Research Associate to join our team. Our lab is studying innate immunity of the lung, focusing on anti-viral effects of pulmonary surfactant phospholipids against respiratory viruses (e.g., Respiratory syncytial virus (RSV), Influenza A, Rhinovirus and SARS-CoV-2) using primary human airway epithelial cells and immune cells.

Techniques used in the lab include, human primary cell cultures maintained in air-liquid interface cultures, fluorescence microscopy, flow cytometry, ELISA, molecular biology (DNA/RNA isolation, PCR), viral replication to make recombinant viruses and in vivo animal models. Training on specific techniques used in the laboratory will be provided. Significant experience with bacterial culture and molecular biology and/or mammalian cells is strongly preferred.

While prior experience is not required for this position, candidates who have been exposed to basic research methods and show enthusiasm for basic science research are strongly preferred. The work performed will be under the supervision of Dr. Numata-Nakamura, or other senior personnel. The ideal candidate should demonstrate attention to detail and be organized, responsible, and a good communicator. Additional tasks will include general laboratory maintenance and operations. A cover letter is required for review of the application.

Application Deadline: Open Until Filled

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4. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

To perform, on a very independent basis, all phases of experimental investigations and to collaborate with Principal Investigators and senior researchers in the progress of major research projects. To act as technical advisor to laboratory technical, support and auxiliary staff.

Application Deadline: Open Until Filled

More Details

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5. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Dooms laboratory in the Department of Immunology and Genomic Medicine at National Jewish Health, Denver, Colorado is seeking to recruit a highly motivated and skilled Postdoctoral Research Fellow to study the role of T cells in autoimmune diseases.

Our laboratory is interested in understanding how T cells become dysregulated and cause autoimmunity. We are specifically investigating how T cell exhaustion, caused by chronic antigen exposure, may play protective or pathogenic roles in autoimmune diseases, and how this mechanism can be exploited for therapeutic intervention. We are currently using samples from Systemic Sclerosis patients and the NOD mouse model of Type 1 Diabetes to answer these questions.

Application Deadline: Open Until Filled

More Details

6. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

Our lab studies host-pathogen interactions with the goal of defining host and bacterial pathways involved in bacterial persistence. Bacterial interactions with the host involve dynamic exchanges where heterogeneity from both sides can lead to many different outcomes. Persistence occurs when the pathogen evades the host immune response and the host is unable to clear the invading pathogen, resulting in stable bacterial colonization.

Individuals with persistent infections often do not respond to long-term or repeated appropriate antibiotic treatment and, importantly, serve as reservoirs for the development of antibiotic resistance. We do not understand why certain infections progress to persistence while others do not. Moreover, the host pathways that lead to persistence have remained an underexplored area of investigation. We hypothesize that bacterial persistence within a host is the result of a complex interplay of specific host and pathogen molecular pathways and that understanding these pathways will allow harnessing host immunity to shift the balance from persistence to clearance of infections.

Our lab will utilize transcriptional analysis at the single cell level and functional perturbations of both the host and the pathogen to understand how persistence is established and maintained. Our lab uses in vitro and in vivo murine and human models of Pseudomonas aeruginosa infection of epithelial cells.

Application Deadline: Open Until Filled

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7. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The lab studies maternal effects on the immune system and development of allergic diseases, with a major focus on asthma (lab). A proportion of patients with asthma develop symptoms of their disease very early in life, sometimes in the 1st year. Genetic factors are contributory, but fail to fully explain why. It is therefore increasingly recognized that development of early-life asthma is dependent in substantial part on environmental exposures that are encountered by infants after birth and exposures and health status of their mothers during pregnancy and breastfeeding. Dr. Gorska’s lab is focused on maternal factors, trying to delineate the mechanisms underlying their effects in offspring.

Application Deadline: Open Until Filled

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8. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

To perform, on a very independent basis, all phases of experimental investigations and to collaborate with Principal Investigators and senior researchers in the progress of major research projects. To act as technical advisor to laboratory technical, support and auxiliary staff.

Application Deadline: Open Until Filled

More Details

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9. Postdoctoral Position 

Summary of Postdoctoral Fellowship:

The Postdoctoral Research Associate will work on an individualized project in the field of COPD and the effects of sphingolipids in the development of lung disease in vivo and also using ex vivo tissue culture using lung cells derived from patient donors. Generate data on Sphingosine Kinase and Sphingosine-1 Phosphate models as they pertain to the development of emphysema, and to generate figures for presentation and publication at national and international meetings.

Application Deadline: Open Until Filled

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